Obesity and vitamin <scp>D</scp> deficiency: a systematic review and meta‐analysis

Pereira, Marcos; Costa, Priscila Ribas de Farias; Assis, Ana Marlúcia Oliveira; Santos, Celso A. S.; Santos, Djanilson Barbosa dos

doi:10.1111/obr.12239

Cited by 717 publications

(560 citation statements)

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“…High waist circumference was observed in the Vitamin D Deficiency group, which can be attributed to the active role that vitamin D plays in the adipose tissue by modulating the inflammatory response and reducing adipogenesis and adipocyte secretion [39]. A meta-analysis including groups of different ages found an association between vitamin D deficiency and obesity, regardless of age, latitude, cutoff point for vitamin deficiency, and the Human Development Index of the region where the study was carried out [40].…”

Section: Discussionmentioning

confidence: 99%

Body composition and metabolic profile in adults with vitamin D deficiency

et al. 2017

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A B S T R A C T ObjectiveTo investigate the body composition and metabolic profile in individuals in terms of different concentrations of serum vitamin D, ranging from deficiency to sufficiency. MethodsA cross-sectional study of 106 adults of both genders, who were divided into three groups according to vitamin D levels: deficiency: <20ng/mL; insufficiency: 20-29.9ng/mL; and sufficiency: 30-100ng/mL. Anthropometric evaluation included weight, height, and body circumferences. Fat mass and lean mass were assessed using the Tetrapolar bioelectrical impedance method. Clinical and biochemical evaluations were also carried out. Insulin resistance was estimated using the Homeostasis Model Assessment Insulin index. ResultsThe analysis showed that the main alterations in individuals in the vitamin D deficiency group were higher triglycerides, very low density lipoprotein -cholesterol, fasting blood glucose, insulin, glycated hemoglobin, body mass index, body fat percentage, lean mass percentage, waist circumference, and Homeostasis Model Assessment Insulin than those of the vitamin D sufficient group (p<0.05).

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Section: Discussionmentioning

confidence: 99%

Body composition and metabolic profile in adults with vitamin D deficiency

et al. 2017

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“…In summary, both calcium and vitamin D absorption are diminished with aging leading to their lower serum concentration (Gallagher 2013). There is a strong relationship between low calcidiol concentrations and increasing levels of obesity (Pereira-Santos et al 2015). It has been shown that even when controlling for sunlight exposure, obese individuals are significantly more likely to have lower calcidiol concentration, indicating inadequate vitamin D status , Pereira-Santos et al 2015.…”

Section: Calcitriol As a Mediator For All Three Tissuesmentioning

confidence: 99%

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Jafarinasabian

Inglis

Reilly

et al. 2017

Journal of Endocrinology

223

147

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Aging affects almost all physiological processes, but changes in body composition and body phenotype are most observable. In this review, we focus on these changes, including loss of bone and muscle and increase in body fat or redistribution of the latter, possibly leading to osteosarcopenic obesity syndrome. We also address low-grade chronic inflammation, prevalent in aging adults and a cause of many disorders including those associated with body composition. Changes in dietary intake and nutritional requirements of older individuals, that all may lead to some disturbances on tissue and organ levels, are discussed as well. Finally, we discuss the hormonal changes in the aging body, considering each of the tissues, bone, muscle and fat as separate endocrine organs, but yet in the continuous interface and communication with each other. Although there are still many unanswered questions in this field, this review will enable the readers to better understand the aging human body and measures needing to be implemented toward reducing impaired health and disability in older individuals.

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“…Indeed, serum 25(OH)D is consistently lower in obese than lean individuals (94) . A recent meta-analysis found that prevalence of VD deficiency was 35 % higher in obese and 25 % higher in overweight compared with lean subjects (95) . In addition, 25(OH)D plasma levels are inversely correlated to all the parameters of obesity, including BMI, fat mass and waist circumference (96,97) , and increased dietary intake of VD, resulting in higher 25(OH)D plasma levels, is associated with a lower visceral adiposity (98) .…”

Section: Effects Of Vitamin D On Obesity and Associated Disorders Inmentioning

confidence: 99%

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

et al. 2015

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Cross-sectional studies depict an inverse relationship between vitamin D (VD) status reflected by plasma 25-hydroxy-vitamin D and obesity. Furthermore, recent studies in vitro and in animal models tend to demonstrate an impact of VD and VD receptor on adipose tissue and adipocyte biology, pointing to at least a part-causal role of VD insufficiency in obesity and associated physiopathological disorders such as adipose tissue inflammation and subsequent insulin resistance. However, clinical and genetic studies are far less convincing, with highly contrasted results ruling out solid conclusions for the moment. Nevertheless, prospective studies provide interesting data supporting the hypothesis of a preventive role of VD in onset of obesity. The aim of this review is to summarise the available data on relationships between VD, adipose tissue/adipocyte physiology, and obesity in order to reveal the next key points that need to be addressed before we can gain deeper insight into the controversial VD-obesity relationship.Adipose tissue: Vitamin D: Obesity: Inflammation: Adipocytes: Nutrients: Nutrition Vitamin D: a brief overview Vitamin D (VD; calciferol) is a hormone mainly described for its role as a regulator of phosphate and calcium homeostasis (1) . It can be obtained through animal (VD 3 , cholecalciferol) or plant (VD 2 , ergocalciferol) food sources. Only a few foodstuffs contain significant amounts of VD, the main sources being fish liver oils, fatty fish (sardines, herring and mackerel) and egg yolk (2,3) , but small quantities are also found in fortified milk, orange juice, bread and cereals. Alternatively, VD 3 is produced endogenously in the skin after UVB irradiation from the precursor 7-dehydrocholesterol to give pre-VD 3 , which is further isomerised to VD 3 before being released into the circulation (4) . Classical estimates have assigned a majority (70-90 %) of VD supply to dermal synthesis, but a recent paper revised this figure down to just 10-25 % of VD supply (5) and posited that dietary intake of 25-hydroxy-vitamin D (25(OH)D) is a significant contributor to total VD input.Adipose tissue is a major storage site for vitamin D Despite limited data, it is widely accepted that adipose tissue is a reservoir for VD in human subjects and rats (6)(7)(8)(9)(10) . Interestingly, visceral fat was found to contain 20 % more VD than subcutaneous fat (11) . Heaney et al. (12) calculated that 65 % of total VD in the body is in the form of D 3 , for which adipose tissue and skeletal muscle appear to be the main body stores (accounting for 73 and 16 %, respectively).

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Obesity and vitamin D deficiency: a systematic review and meta‐analysis

Cited by 717 publications

References 49 publications

Body composition and metabolic profile in adults with vitamin D deficiency

Body composition and metabolic profile in adults with vitamin D deficiency

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

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