Obesity as disruptor of the female fertility

Silvestris, Erica; Pergola, Giovanni De; Rosania, Raffaele; Loverro, Giuseppe

doi:10.1186/s12958-018-0336-z

Cited by 420 publications

(389 citation statements)

References 77 publications

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“…Obesity is already recognized as a disease that interferes with fertility [28,29]. Obesity may affect a woman's fertility via numerous events, such as impairment of ovarian follicles development, qualitative and quantitative defects in oocyte maturation, altered fertilization, disrupted meiosis, and mitochondrial dynamics de- rangements leading to abnormal embryo preimplantation [30].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Kim

Lee

Yun

et al. 2018

Gynecol Obstet Invest

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Aims: Our objective was to predict natural pregnancy after endometriosis surgery using the endometriosis fertility index (EFI). Methods: A retrospective medical records review was conducted, examining patients surgically treated for endometriosis at a single center in Korea between January 2009 and February 2015. In total, 68 women attempting natural conception were analyzed by assessing age, preoperative serum CA-125, body mass index, revised American Fertility Society (rAFS) stage, EFI, and pregnancy outcome. Kaplan-Meier estimates and log-rank tests were used to generate cumulative natural pregnancy rate curves based on an EFI cut-point. A receiver-operating characteristic (ROC) curve was plotted for EFI. Results: Seventy-seven patients attempted conceptions, resulting in 33 natural and 9 assisted conceptions. Excluding assisted conceptions, the mean EFI scores of 68 women who were not pregnant and pregnant were 5.43 ± 0.36 and 6.88 ± 0.28 respectively. The relation between EFI and natural pregnancy was significant (cumulative overall pregnancy rate, p = 0.006), whereas rAFS stage was not (univariate logistics, p = 0.853). The cut-point for maximum natural pregnancy outcomes was 6 (area under ROC curve = 0.710, 95% CI 0.586–0.835). Conclusion: The EFI is a reliable staging system for predicting natural pregnancy after endometriosis surgery. EFI scores can be used to guide postoperative treatment of women with endometriosis.

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Section: Discussion/conclusionmentioning

confidence: 99%

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Kim

Lee

Yun

et al. 2018

Gynecol Obstet Invest

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“…The excess estrogens produced by the adipose tissue provides a growth signal for the endometrium that is unopposed by progesterone. Obesity also leads to higher rates of anovulation [ 21 ] with a relative risk above 2 for body mass index greater than 29 [ 22 ]; however, most obese women have normal ovulatory menstrual cycles [ 23 ]. In anovulatory women, the lack of ovulation and corpus luteum production keeps progesterone levels low.…”

Section: Estrogen-associated Risk Factors For Endometrial Cancermentioning

confidence: 99%

Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions

et al. 2019

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Endometrial cancer is the most common gynecological cancer in the developed world, and it is one of the few cancer types that is becoming more prevalent and leading to more deaths in the USA each year. The majority of endometrial tumors are considered to be hormonally driven, where estrogen signaling through estrogen receptor α (ER) acts as an oncogenic signal. The major risk factors and some treatment options for endometrial cancer patients emphasize a key role for estrogen signaling in the disease. Despite the strong connections between estrogen signaling and endometrial cancer, important molecular aspects of ER function remain poorly understood; however, progress is being made in our understanding of estrogen signaling in endometrial cancer. Here, we discuss the evidence for the importance of estrogen signaling in endometrial cancer, details of the endometrial cancer-specific actions of ER, and open questions surrounding estrogen signaling in endometrial cancer.

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“…Obesity is reportedly associated with female infertility and is one of the major factors, especially in Saudi Arabia, because females are highly obese when compared with males, and the overall prevalence of obesity in the Saudi Arabia is 35.5% (Rafique and Nuzhat, 2016). However, recent lifestyle of female reproductive health is protected towards BMI, nutrients, physical activity, and stress-related jobs (Silvestris et al, 2018). Dağ and Dilbaz (2015) concluded that dropping weight would be beneficial for the reproductive effect in infertile women.…”

Section: Discussionmentioning

confidence: 99%

Role of C677T polymorphism in the MTHFR gene in Saudi females affected with infertility

Al-Mutawa¹

2019

Int. j. adv. appl. sci.

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The methylenetetrahydrofolate reductase (MTHFR) gene plays a major role in folate metabolism in infertile women. To date, limited studies have implicated the C677T polymorphism in MTHFR with female infertility, which is defined as the failure to accomplish clinical pregnancy with consistent unprotected sexual intercourse for 1 year; this disorder is influenced by various factors, including obesity and it affects in ~15% of couples during the reproductive period. However, limited molecular studies have been conducted pertaining to female infertility. The current study aimed to investigate the correlation between the C677T polymorphism in MTHFR and infertility in a Saudi population. In this study, 300 genomic DNA samples were extracted from 150 infertile and 150 fertile women, and genotyping was performed for the C677T polymorphism in MTHFR by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The results revealed that the mutant T allele was significantly associated with infertility (odds ratio [OR] = 1.86; 95% CI = 1.15-2.99; p = 0.009). Additionally, the dominant and recessive modes of inheritance were positively associated with infertility, i.e., TT vs. CT+CC (OR = 2.98; 95% CI = 1.33-6.66; p = 0.005) and TT+CT vs. CC (OR = 1.89; 95% CI = 1.09-3.26; p = 0.02). The current results indicate that the T allele of the C677T polymorphism in MTHFR is a significant risk factor for infertility in women from a Saudi population.

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Obesity as disruptor of the female fertility

Cited by 420 publications

References 77 publications

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions

Role of C677T polymorphism in the MTHFR gene in Saudi females affected with infertility

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