Obesity-associated alterations in glucose metabolism are reversed by chronic bilateral stimulation of the abdominal vagus nerve

Malbert, CH; Picq, C.; Divoux, Jean-Louis; Henry, Christine; Horowitz, Michael

doi:10.1016/j.brs.2017.01.372

Cited by 13 publications

(18 citation statements)

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“…Using a large animal model of insulin resistance without constant hyperglycemia (e.g., in a prediabetic condition), we found that vagal stimulation induces an increase in whole body glucose uptake that leads to improved insulin sensitivity which itself resulted in a reduction in fasting glucose [5]. We further demonstrated that insulin-mediated hepatic and skeletal muscle glucose uptakes were impaired by obesity and reversed by vagal stimulation.…”

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confidence: 62%

“…Accordingly, personalized medicine is necessary, balancing the benefits of glycemic control with its potential risks, taking into account the adverse effects of glucose-lowering medications (e.g., particularly hypoglycemia) and the patient's age and health status. Recently our group has been focusing on vagal stimulation as a minimally invasive strategy for weight loss and improvement of insulin sensitivity [3][4][5][6]. Together with new surgical approaches and innovative, stimulating schemes, this might provide an interesting alternative therapeutic approach.…”

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confidence: 99%

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Could Vagus Nerve Stimulation Have a Role in the Treatment of Diabetes?

Malbert

2017

Bioelectron. Med.

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confidence: 62%

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confidence: 99%

Could Vagus Nerve Stimulation Have a Role in the Treatment of Diabetes?

Malbert

2017

Bioelectron. Med.

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“…In addition to confirming that chronic VNS raises blood glucose concentrations, a recent animal trial also revealed that cervical VNS impairs glucose tolerance [12] . In contrast, data from a previous study showed that efferent cervical VNS lowered blood glucose concentrations by activation of insulin secretion [11] , whereas analysis of the study conducted in obese pigs indicated that chronic bilateral vagal stimulation has the capacity to restore fasting glucose metabolism [13] . Similarly, Yin et al.…”

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confidence: 73%

Chronic vagus nerve stimulation for drug-resistant epilepsy may influence fasting blood glucose concentration

Liu

Zhan

Meng

et al. 2020

Preprint

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Background Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood. The aim of our study was to investigate the potential effects of VNS on fasting blood glucose (FBG) in patients with drug-resistant epilepsy. Methods Patients with drug-resistant epilepsy who had received VNS implants at the same hospital were retrospectively studied. Effects on FBG, weight, body mass index and blood pressure were evaluated at 4, 8 and 12 months of follow-up. Results 32 subjects (11 females/21males, 19±9 years, body mass index 22.2±4.0 kg/m 2 ) completed 12-month follow-up. At the 4 months, there were no significant changes in FBG concentrations from baseline to follow-up in both Sham-VNS (4.89±0.54 vs. 4.56±0.54 mmol/L, N=13, p=0.101) and VNS (4.80±0.54 vs. 4.50±0.56 mmol/L, N=19, p=0.117) groups. However, after 8 (4.90±0.42 mmol/L, N=32, p=0.001) and 12 (4.86±0.40 mmol/L, N=32, p=0.002) months of VNS, FBG levels significantly increased compared to baseline values (4.52±0.54 mmol/L, N=32). Changes in FBG concentrations at both 8 (R 2 =0.502, N=32, p<0.001) and 12 (R 2 =0.572, N=32, p<0.001) months were negatively correlated with baseline FBG levels. Conclusions Our study suggests that chronic cervical VNS elevates FBG levels with commonly used stimulation parameters in patients with epilepsy.

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“…These objectives were carried out using the large white pig as a large animal model of normal human physiology (23). Furthermore, the size of the animal is well suited for laparoscopic surgery and for brain imaging using high end clinical PET scanners (24).…”

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confidence: 99%