Obesity augments the disease burden in COVID‐19: Updated data from an umbrella review

Kristensen, Nickolai Malte; Gribsholt, Sigrid Bjerge; Andersen, A L; Richelsen, Bjørn; Bruun, Jens Meldgaard

doi:10.1111/cob.12508

Cited by 20 publications

(29 citation statements)

References 66 publications

(506 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…About one in five individuals worldwide is at increased risk of severe COVID-19 due to underlying health conditions, and suffers from at least one non-communicable disease [ 18 ]. This trend is particularly true with the progressive ageing of the population and the global dual epidemic of obesity and type 2 diabetes mellitus, which drive the worst outcomes of COVID-19 patients [ 19 ]. Notably, such leading noncommunicable diseases affect people independently from age.…”

Section: The Pandemic As a Component Of A Syndemicmentioning

confidence: 99%

Environmental health, COVID-19, and the syndemic: internal medicine facing the challenge

Ciaula

Moshammer

Lauriola³

et al. 2022

Intern Emerg Med

View full text Add to dashboard Cite

Internists are experts in complexity, and the COVID-19 pandemic is disclosing complex and unexpected interactions between communicable and non-communicable diseases, environmental factors, and socio-economic disparities. The medicine of complexity cannot be limited to facing comorbidities and to the clinical management of multifaceted diseases. Evidence indicates how climate change, pollution, demographic unbalance, and inequalities can affect the spreading and outcomes of COVID-19 in vulnerable communities. These elements cannot be neglected, and a wide view of public health aspects by a “one-health” approach is strongly and urgently recommended. According to World Health Organization, 35% of infectious diseases involving the lower respiratory tract depend on environmental factors, and infections from SARS-Cov-2 is not an exception. Furthermore, environmental pollution generates a large burden of non-communicable diseases and disabilities, increasing the individual vulnerability to COVID-19 and the chance for the resilience of large communities worldwide. In this field, the awareness of internists must increase, as privileged healthcare providers. They need to gain a comprehensive knowledge of elements characterizing COVID-19 as part of a syndemic. This is the case when pandemic events hit vulnerable populations suffering from the increasing burden of chronic diseases, disabilities, and social and economic inequalities. Mastering the interplay of such events requires a change in overall strategy, to adequately manage not only the SARS-CoV-2 infection but also the growing burden of non-communicable diseases by a “one health” approach. In this context, experts in internal medicine have the knowledge and skills to drive this change.

show abstract

Section: The Pandemic As a Component Of A Syndemicmentioning

confidence: 99%

Environmental health, COVID-19, and the syndemic: internal medicine facing the challenge

Ciaula

Moshammer

Lauriola³

et al. 2022

Intern Emerg Med

View full text Add to dashboard Cite

show abstract

“…Also, the renal injury in COVID-19 may be more persistent than that of acute kidney injury (AKI) of other infectious causes [ 4 ] and contribute to lung injury. Patients with chronic obstructive pulmonary disease have substantially increase mortality [ 5 ] as do younger patients with increased body mass index (BMI) [ 6 ].…”

mentioning

confidence: 99%

Cardiac manifestations in critically ill patients with COVID-19: do we really know what hit us?

Hjortrup

Butt

2022

Intensive Care Med

View full text Add to dashboard Cite

“…Obesity and confusion (dizziness) at the time admission, as well as the history of hypertension were associated with all three outcome measures. Obesity may be associated with increased mortality in COVID-19 (29). Dizziness has also been reported as an indicator of critical outcome in COVID-19 (30).…”

Section: Discussionmentioning

confidence: 99%

Severity and prognostic factors of SARS-CoV-2-induced pneumonia: The value of clinical and laboratory biomarkers and the A-DROP score

Szabó

Kardos

Oláh³

et al. 2022

Front. Med.

View full text Add to dashboard Cite

IntroductionNumerous clinical and laboratory scores that include C-reactive protein (CRP), D-dimer, ferritin, lactate dehydrogenase (LDH), interleukin 6 (IL-6), procalcitonin (PCT), blood urea nitrogen (BUN), creatinine levels and oxygenation (PaO2 and SaO2) have been used for the prognosis of COVID-19. In addition, composite scores have been developed for the assessment of general state and risk in community-acquired pneumonia (CAP) that may be applied for COVID-19 as well. In this study, we assessed severity and potential prognostic risk factors for unfavorable outcome among hospitalized COVID-19 patients. We also applied the A-DROP general scoring system used in CAP to COVID-19.Patients and methodsAltogether 233 patients admitted to our center with COVID-19 were included in the study. Clinical status, several laboratory biomarkers described above, indicators of oxygenation were determined at hospital admission. We also applied the A-DROP composite scoring system that includes Age (≥ 70 years in males and ≥ 75 years in females), Dehydration (BUN ≥ 7.5 mmol/l), Respiratory failure (SaO2 ≤ 90% or PaO2 ≤ 60 mmHg), Orientation disturbance (confusion) and low blood Pressure (systolic BP ≤ 90 mmHg) to COVID-19.ResultsAt the time of admission, most patients had elevated CRP, LDH, ferritin, D-dimer, and IL-6 levels indicating multisystemic inflammatory syndrome (MIS). Altogether 49 patients (21.2%) required admission to ICU, 46 (19.7%) needed ventilation and 40 patients (17.2%) died. In the binary analysis, admission to ICU, the need for ventilation and death were all significantly associated with the duration of hospitalization, history of hypertension or obesity, confusion/dizziness, as well as higher absolute leukocyte and neutrophil and lower lymphocyte counts, elevated CRP, PCT, LDH, ferritin, IL-6, BUN, and creatinine levels, low PaO2 and SaO2 and higher A-DROP score at the time of admission (p < 0.05).ConclusionNumerous laboratory biomarkers in addition to obesity, dizziness at the time of admission and the history of hypertension may predict the need for ICU admission and ventilation, as well as mortality in COVID-19. Moreover, A-DROP may be a suitable scoring system for the assessment of general health and disease outcome in COVID-19.

show abstract

Obesity augments the disease burden in COVID‐19: Updated data from an umbrella review

Cited by 20 publications

References 66 publications

Environmental health, COVID-19, and the syndemic: internal medicine facing the challenge

Environmental health, COVID-19, and the syndemic: internal medicine facing the challenge

Cardiac manifestations in critically ill patients with COVID-19: do we really know what hit us?

Severity and prognostic factors of SARS-CoV-2-induced pneumonia: The value of clinical and laboratory biomarkers and the A-DROP score

Contact Info

Product

Resources

About