Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle thousand families study

Rudman, H A; Birrell, Fraser; Pearce, Mark S.; Tuck, Stephen; Francis, Roger M.; Treadgold, Laura A.; Hind, Karen

doi:10.1007/s00198-018-04817-3

Cited by 25 publications

(23 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the bone health is often deteriorated in individuals with increased fat mass (Shapses et al, 2017). The prevalence of vertebral fractures are higher in individuals with obesity (Rudman et al, 2019) and the occurrence of osteoporosis, particularly in postmenopausal women, is associated with increased body weight (Hsu et al, 2006). High-fat diet-induced body weight gain enhance bone resorption and elevate osteoclasts in bone marrow (Cao et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

N,N-Dimethlyacetamide Prevents the High-Fat Diet-Induced Increase in Body Weight

et al. 2019

View full text Add to dashboard Cite

Increased body weight caused by visceral fat accumulation is on the rise and is reaching epidemic proportions worldwide. Hence, means and ways to tackle the problem of increased adiposity is of utmost importance. In this work, we report the effect of a water-soluble small molecule N,N-Dimethlyacetamide (DMA) on weight gain and adiposity in vitro and in vivo. To monitor the in vitro effect of DMA on adipogenesis, 3T3-L1 preadipocytes and pluripotent C2C12 cells were differentiated to adipocytes in the presence of DMA (5 mM and 10 mM). Oil red O staining and reverse transcriptase polymerase chain reaction (RT-PCR) were performed to evaluate the differentiation to adipocytes. To study the in vivo effect of DMA on body weight, experiments were done with C57BL/6J male mice (6 weeks old). The mice were randomly assigned to receive either high-fat diet (HFD; 45% fat) or a normal diet (7% fat) and were either intraperitoneally injected with DMA or phosphate-buffered saline (PBS) once a week for 20 weeks. Glucose tolerance test was performed on living mice. Post-experiment, the epididymal and subcutaneous adipose tissue were excised from the sacrificed animal, and histology, RT-PCR and plasma triglyceride assay were performed. DMA had no inhibitory effect on adipocyte differentiation when applied only once. However, sustained treatment with DMA inhibited the adipocyte differentiation in both 3T3-L1 and C2C12 cells, and significantly lowered the expression of adipocyte markers, in particular, fatty acid-binding protein 4 (fabp4). Under HFD, C57BL/6J mice treated with DMA had lower body weight compared with PBS treatment. Moreover, the HFD-induced higher body weight was controlled when the mice were switched from PBS to DMA treatment. Further, the HFD-mediated adipocyte hypertrophy from epididymal and subcutaneous adipose tissue was significantly reduced with DMA treatment. Interestingly, the glucose clearance and triglyceride levels in the plasma were improved in mice when DMA treatment was initiated early. Taken together, our results show that DMA exhibits a clear potential to prevent weight gain and restricts adiposity in response to high-fat feeding.

show abstract

Section: Introductionmentioning

confidence: 99%

N,N-Dimethlyacetamide Prevents the High-Fat Diet-Induced Increase in Body Weight

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Fewer studies on osteoporosis have been conducted in males than in females. Recent studies indicated that visceral adipose tissue was also a risk factor for osteoporosis in men [4,17] and that obese men were more likely to have vertebral fracture than men of normal weight [5]. Another study indicated that obesity induced by a HFD aggravated bone loss in the cancellous bone compartment, with a greater loss in males than females [18].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, compared to women of normal weight, obese women were more likely to have at least one vertebral fracture and at least one mild vertebral deformity. Obese men were more likely to have a moderate and/or severe vertebral fracture compared to men of normal weight [5]. However, no specific pharmacotherapy has been approved.…”

Section: Introductionmentioning

confidence: 99%

Possible therapeutic effects of berberine on bone damage in high-fat diet-induced obese rats

Wang¹,

Chen²,

Wang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Obesity has a negative impact on bone health; thus far, no specific pharmacotherapy has been approved. Berberine has shown improvements in osteoporosis in some animal models. However, it remains unknown whether berberine ameliorates obesity-induced bone damage. This study aims to evaluate the effect of berberine on bone damage in high-fat diet (HFD)-induced obese rats. Methods Male Sprague-Dawley rats were randomly assigned to a normal control diet (ND) group or HFD group. After the HFD induced obesity, the models were successfully established. Then, these rats were randomly divided into the HFD + berberine (HB) group or HFD group and were intraperitoneally administered berberine or an equivalent volume of DMSO, respectively, once a day for another 10 weeks. Micro-CT and three-point bending tests were conducted to evaluate bone microstructure and biomechanics. Serum was collected for the detection of P1NP, CTX-1, calcium (Ca) and phosphorus (P), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). HE staining was performed to observe the number of trabecular and bone marrow adipocytes. Results HFD-induced obese rats displayed decreased biomechanical properties, such as maximum load, maximum fracture load, ultimate tensile strength, stiffness, and energy absorption, compared with the ND rats (p<0.05). However, berberine attenuated bone damage, including maximum load, maximum fracture load, and stiffness, in the HB group compared with the HFD group (p<0.05). Trabecular bone markers were decreased in the HFD group compared with the ND group (p<0.05). All parameters were improved, as shown by micro-CT and HE staining, in the HB group compared to the HFD group. Cortical bone markers were not significantly different among all groups. Moreover, CTX-1, TNF-α, IL-1β and the number of adipocytes in bone marrow were significantly increased in HFD-induced obese rats. After treatment with berberine, TNF-α, IL-1β and the number of adipocytes in bone marrow were significantly decreased, and P1NP levels were higher in the HB group than in the HFD group. Conclusions Berberine might be a potential therapeutic agent for treating bone damage in HFD-induced obese rats by inhibiting inflammatory factors, reducing bone marrow adiposity and improving bone formation.

show abstract

“…Nevertheless, the T scores do not take into account BMI. Obesity protects from osteoporosis but the relative BMD for BMI may be lower in obese women compared with normal‐weight women, which might contribute to a higher risk of fractures …”

Section: Discussionmentioning

confidence: 99%

“…Obesity protects from osteoporosis but the relative BMD for BMI may be lower in obese women compared with normal-weight women, which might contribute to a higher risk of fractures. 31 One previous cohort study of 480 women, among whom 96 had GDM, reported greater BMD losses from early pregnancy to third trimester of pregnancy in women with GDM compared with women without GDM. 32 Within women with GDM, lower initial BMD values, higher fat accumulation and higher early-pregnancy BMI were associated with lower BMD loss.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 98%

Bone health in women with a history of gestational diabetes or obesity

Engberg

Koivusalo

Huvinen

et al. 2019

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Introduction Type 2 diabetes is associated with an increased risk of bone fractures. However, bone health of women with a history of gestational diabetes (GDM) has received little attention. This cross‐sectional study compares bone health between premenopausal women with and without a history of GDM, and examines factors associated with bone health in women with a history of GDM or obesity. Material and methods We measured areal bone mineral density for total hip, lumbar spine and whole body, and total body fat percentage (fat%) with dual‐energy X‐ray absorptiometry in 224 women. In addition, we measured bone characteristics of radius and tibia with peripheral quantitative computed tomography. Results When compared with women without a history of GDM (mean age 39 years [SD 5], body mass index [BMI] 35 kg/m2 [SD 6], fat% 48 [SD 7]), women with a history of GDM (age 41 years [SD 4], BMI 31 kg/m2 [SD 7], fat% 43 [SD 10]) had lower hip and whole body bone mineral densities, and inferior tibia outcomes. However, the differences in bone characteristics disappeared after controlling for age, height, BMI and fat%. After controlling for age, height, BMI and smoking, physical activity and healthier diet were positively associated with bone outcomes, whereas fat%, HbA1c and screen time were negatively associated with bone outcomes. Particularly, fat% showed independent negative associations with whole body bone mineral density and several tibia and radius characteristics. Conclusions Fat% is associated with adverse bone health, independently of BMI, in women with a history of GDM or obesity. Promoting healthy lifestyle and reducing fat% in high‐risk women could improve bone health and prevent future fractures.

show abstract

Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle thousand families study

Cited by 25 publications

References 43 publications

N,N-Dimethlyacetamide Prevents the High-Fat Diet-Induced Increase in Body Weight

N,N-Dimethlyacetamide Prevents the High-Fat Diet-Induced Increase in Body Weight

Possible therapeutic effects of berberine on bone damage in high-fat diet-induced obese rats

Bone health in women with a history of gestational diabetes or obesity

Contact Info

Product

Resources

About