Obesity, But Not High Fat Diet, Impairs Lymphatic Function

Nores, Gabriela D. García; Gardenier, Jason C.; Savetsky, Ira L.; Torrisi, Jeremy S.; Nitti, Matthew D.; Hespe, Geoffrey E.; Kataru, Raghu P.; Mehrara, Babak J.

doi:10.1016/j.jamcollsurg.2015.07.274

Cited by 11 publications

(16 citation statements)

References 54 publications

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“…One of the extrinsic features that contribute to this deregulation, along with oxygen and pH, is the nutrient composition of the local environment. Diet‐driven changes in circulating nutrients (Lai et al , ), the function of draining lymph nodes (García Nores et al , ), and the tissue vasculature (Carmona‐Fontaine et al , ) all play roles in altering nutrient availability to solid tumors in this organ environment. Therefore, each organ has a unique metabolic profile making its local environment a particular soil for cancer cells to grow (Table ).…”

Section: Introductionmentioning

confidence: 99%

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take

et al. 2020

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Nutrients are indispensable resources that provide the macromolecular building blocks and energy requirements for sustaining cell growth and survival. Cancer cells require several key nutrients to fulfill their changing metabolic needs as they progress through stages of development. Moreover, both cell-intrinsic and microenvironment-influenced factors determine nutrient dependencies throughout cancer progression-for which a comprehensive characterization remains incomplete. In addition to the widely studied role of genetic alterations driving cancer metabolism, nutrient use in cancer tissue may be affected by several factors including the following: (i) diet, the primary source of bodily nutrients which influences circulating metabolite levels; (ii) tissue of origin, which can influence the tumor's reliance on specific nutrients to support cell metabolism and growth; (iii) local microenvironment, which dictates the accessibility of nutrients to tumor cells; (iv) tumor heterogeneity, which promotes metabolic plasticity and adaptation to nutrient demands; and (v) functional demand, which intensifies metabolic reprogramming to fuel the phenotypic changes required for invasion, growth, or survival. Here, we discuss the influence of these factors on nutrient metabolism and dependence during various steps of tumor development and progression.

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Section: Introductionmentioning

confidence: 99%

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take

et al. 2020

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“…However, different factors can contribute to the aggravation of lymphedema, such as erysipelas, trauma and radiotherapy. Obesity has also been associated with lower limb lymphedema and is therefore yet another aggravating factor [3].…”

Section: Introductionmentioning

confidence: 99%

“…Animal studies have demonstrated that the increase in weight in obesity can trigger changes in the lymphatic pumping mechanism, capillary permeability and the immune system [3,4]. Bioimpedance analysis enables the determination of total intracellular and extracellular water as well as water in isolated extremities and the trunk and has demonstrated an increase in total body water with the progression of lymphedema [5].…”

Section: Introductionmentioning

confidence: 99%

Subclinical systemic lymphedema and its progression

Godoy¹

2019

Our Dermatol Online

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“…The authors also found that visceral obesity causes lymphatic endothelial cell injury, down‐regulation of VEGF receptor 3 and Prox1 , a transcription factor required for lymphatic differentiation as well as perilymphatic lipid accumulation (Garcia Nores et al . ). Notably, perilymphatic inflammation was absent in an obesity‐resistant mouse strain fed the same high‐fat diet (Garcia Nores et al .…”

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confidence: 97%

“…Notably, perilymphatic inflammation was absent in an obesity‐resistant mouse strain fed the same high‐fat diet (Garcia Nores et al . ). Happloinsufficiency of Prox1 results in lymphatic dysfunction and adult‐onset obesity that is independent of diet (Harvey et al .…”

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confidence: 97%