Obesity, but not metabolic control, is associated with muscle strength and endurance in diabetic older adults

Bassi‐Dibai, Daniela; Dibai‐Filho, Almir Vieira; Carvalho, Lívia Pinheiro; Melo, Bianca Cardoso de; Pedrosa, Letícia Bomfim; Mendes, Renata Gonçalves; Caruso, Flávia Cristina Rossi; Borghi‐Silva, Audrey

doi:10.1002/pri.1808

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…In our study, the mean HGS for men and women were 26.6 ± 2.2 kg and 17.7 ± 0.7 kg, respectively (not shown in tables). Interestingly, the literature has showed that obese individuals have higher maximum muscle strength than non-obese individuals, regardless of age (Bassi-Dibai et al , 2020; Tomlinson et al , 2016). Conversely, our results found that obese older adults have significantly lower HGS compared to non-obese older adults (not shown in tables).…”

Section: Discussionmentioning

confidence: 99%

Association between neutrophil to lymphocyte ratio, handgrip strength and nutritional status in geriatric patients

Epçaçan,

Gönül,

Bayram

et al. 2023

NFS

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Purpose This study aims to examine the relationship between neutrophil to lymphocyte ratio (NLR), handgrip strength (HGS) and nutritional status in non-critically ill patients and outpatients. Design/methodology/approach A cross-sectional study was conducted on 80 geriatric patients. Nutritional status was evaluated using the Mini Nutritional Assessment Short Form, Geriatric Nutritional Risk Index, some anthropometric and biochemical parameters. NLR was calculated from the complete blood count results. Data were analyzed using SPSS 24.0. Findings While 38.3% of patients were malnourished or at risk of malnutrition, 61.7% had normal nutritional status. Mini Nutritional Assessment Short Form was not correlated with NLR, whereas it showed a weak positive correlation with HGS. According to the logistic regression analysis, age, HGS, hemoglobin and platelet to lymphocyte ratio were significant independent factors for predicting malnutrition or risk of malnutrition. The receiver operator characteristic curve analysis showed that the optimum HGS cut-off point for patients with malnourished or at risk of malnutrition was 13.2. In conclusion, HGS was associated with the nutritional status. NLR was not associated with nutritional status but associated with nutritional risk. Originality/value It is well known that malnutrition is a serious health problem among older adults, and it is important to assess the nutritional status of older adults because of the adverse health effects. In addition, to the best of the authors’ knowledge, this is the first study to determine the relationship between NLR, HGS and nutritional status in non-critically ill patients and outpatients.

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Section: Discussionmentioning

confidence: 99%

Association between neutrophil to lymphocyte ratio, handgrip strength and nutritional status in geriatric patients

Epçaçan,

Gönül,

Bayram

et al. 2023

NFS

View full text Add to dashboard Cite

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“…that obese (i.e., superior fat mass %) individuals may have greater lean mass compared to non-obese counterparts [17][18][19][20][21] . Also, a positive relationship between body mass index, fat and lean mass amount with KE performance was previously demonstrated 18,[22][23][24] . However, even with a positive relationship between fat mass amount with performance, we do not recommend that athletes seeking superior muscle strength capacity increase their amount of fat mass since a negative relationship between fat mass with the jumping and sprint performance of futsal players [8][9][10] .…”

Section: Lower-limb Body Composition Correlationsmentioning

confidence: 99%

The relationship between lower-limb body composition with isokinetic performance in futsal players: Body composition and performance in futsal players

Machado¹,

Nakamura

Brusco

et al. 2022

BJMB

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BACKGROUND: Optimal neuromuscular performance is essential for futsal athletes and it has been linked to body composition. AIM: The present study aimed to verify the relationship between absolute (total amount; kg) and relative (percentage; %) lower-limb and thigh lean and fat mass with isometric and dynamic maximal strength in professional futsal players. METHOD: Sixteen male elite futsal athletes participated in this study. Unilateral lower-limb and thigh lean and fat mass were evaluated using DXA (Dual-Energy X-ray Absorptiometry) and strength performance using unilateral isokinetic concentric-eccentric knee extension (KE) and flexion (KF) peak torque (PT), KE and KF isometric PT at 30° and 70°, and hamstrings-to-quadriceps ratios (H:Q). RESULTS: Unilateral lower-limb lean mass amount showed a significant positive correlation with concentric and isometric KE PT (60°/s: r=0.58; 30°: r=0.55; 70°: r=0.65), and with concentric (60°/s: r=0.61), eccentric (60°/s: r=0.67) and isometric (30°:r=0.79; 70°: r=0.70) KF PT. No significant relationship between lower-limb lean and fat mass percentage with isokinetic performance was verified. Thigh lean mass amount had a significant positive correlation with concentric and isometric KE PT (60°/s:r=0.52; 30°: r=0.51; 70°: r=0.84) and also with concentric (60°/s: r=0.75) and eccentric KF PT (60°/s:r=0.54), while thigh fat mass amount was only associated with eccentric KF PT (r=0.54). No significant correlation between lower-limb and thigh body composition with H:Q ratios was observed. CONCLUSION: In conclusion, contrary to the relative (%) values, absolute (kg) lower-limb and thigh fat and lean mass present a significant correlation with dynamic and isometric KE and KF performance in futsal players.

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“…Osteopenia (OPe) refers to the decrease in bone mass per unit volume of bone, which can manifest into osteoporosis on further aggravation. In the elderly population, fractures can occur as a primary clinical endpoint for both osteoporosis and persistent history of falls [ 10 ] due to a gradual decrease of lower limb muscle strength, which directly affects the balancing function and the walking ability [ 11 ]. Fatty liver can increase the risk of fractures in osteoporotic patients [ 12 ] and may interact through complex pathways such as inflammatory mediators, hormones, substance metabolism, and intestinal flora imbalance in conjunction with osteoporosis [ 8 ]; however, it has not been clarified yet.…”

Section: Introductionmentioning

confidence: 99%

The Imbalance of Mitochondrial Homeostasis of Peripheral Blood-Derived Macrophages Mediated by MAFLD May Impair the Walking Ability of Elderly Patients with Osteopenia

Wang

Liu

et al. 2022

Oxidative Medicine and Cellular Longevity

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Introduction. Many Asian cohort studies have shown that nonalcoholic fatty liver disease (NAFLD), now renamed as metabolic dysfunction-associated fatty liver disease (MAFLD), increases the risk of osteoporosis, yet the effect of MAFLD on elderly patients with osteopenia (OPe) has not been reported. Objective. This study aimed to explore the influence of MAFLD on the function of macrophages in patients with OPe. Methods. A total of 107 elderly OPe patients with or without MAFLD who visited the Huadong Hospital Affiliated to Fudan University (Shanghai, China) between January 1st, 2021, and September 30th, 2021, were evaluated for an interviewer-assisted questionnaire, as well as clinical and biological assessments. Results. Comparing two groups of elderly patients with the same bone mass level, we found that the six-minute walking distance ( P = 0.012 ) and short physical performance battery (SPPB) score ( P = 0.0029 ) of the elderly OPe patients with MAFLD are worse than those in OPe patients without MAFLD. Our results confirmed that the mitochondrial reactive oxygen species (mtROS) in peripheral blood of OPe patients with MAFLD was significantly higher than those without. We also observed the mitochondrial metabolism level of peripheral blood-derived macrophages in the included patients and peripheral blood macrophages in patients with MAFLD with more unbalanced mitochondrial dynamics of macrophages, more weakened mitochondrial respiratory capacity, and greater mitochondrial microstructure damage, when compared with the elderly patients without MAFLD. Conclusions. To conclude, our data revealed that MAFLD itself may aggravate the inflammatory state in elderly OPe people due to mitochondrial homeostasis imbalance of peripheral blood macrophages. Damaged monocyte-macrophages might trigger attenuation of the walking ability of OPe patients.

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Obesity, but not metabolic control, is associated with muscle strength and endurance in diabetic older adults

Cited by 3 publications

References 25 publications

Association between neutrophil to lymphocyte ratio, handgrip strength and nutritional status in geriatric patients

Association between neutrophil to lymphocyte ratio, handgrip strength and nutritional status in geriatric patients

The relationship between lower-limb body composition with isokinetic performance in futsal players: Body composition and performance in futsal players

The Imbalance of Mitochondrial Homeostasis of Peripheral Blood-Derived Macrophages Mediated by MAFLD May Impair the Walking Ability of Elderly Patients with Osteopenia

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