Obesity can predict and promote systemic inflammation in healthy adults

Ellulu, Mohammed S.; Khaza’ai, Huzwah; Rahmat, Asmah; Patimah, Ismail; Abed, Yacine

doi:10.1016/j.ijcard.2016.04.089

Cited by 59 publications

(47 citation statements)

References 40 publications

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“…The observed correlations with H9N2 and MM can represent differing apolipoprotein B levels or glycosylation thereof, and may be indicative of an unhealthy glycosylation profile with regard to lipid transport and metabolism. The association of MM with inflammatory marker hsCRP is likely a consequence of the connection between inflammation and obesity (84), as a model corrected for BMI no longer shows significant association between high mannose size and inflammation (data not shown). The effect size being less pronounced with hsCRP than with BMI is explainable by the aforementioned increase in IgM, which contains the smaller high-mannose compositions H5N2 and H6N2 at its Asn 279 site (80).…”

Section: Discussionmentioning

confidence: 96%

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health

Reiding

Ruhaak

et al. 2017

Molecular & Cellular Proteomics

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Glycosylation is an abundant co-and post-translational protein modification of importance to protein processing and activity. Although not template-defined, glycosylation does reflect the biological state of an organism and is a high-potential biomarker for disease and patient stratification. However, to interpret a complex but informative sample like the total plasma N-glycome, it is important to establish its baseline association with plasma protein levels and systemic processes. Thus far, large-scale studies (n >200) of the total plasma N-glycome have been performed with methods of chromatographic and electrophoretic separation, which, although being informative, are limited in resolving the structural complexity of plasma N-glycans. MS has the opportunity to contribute additional information on, among others, antennarity, sialylation, and the identity of high-mannose type species.Here, we have used matrix-assisted laser desorption/ ionization ( Glycosylation is a ubiquitous co-and post-translational protein modification of functional relevance to the processing and activity of the conjugate. Examples include quality control during protein folding, regulation of circulatory half-life, and modulation of receptor interactions by either providing the recognition motif or by affecting protein conformation (1-7). Consequentially, glycosylation has been associated with a multitude of diseases and states thereof, among which the progression and metastasis of cancer and the remission of rheumatoid arthritis (8 -11). Because the process of glycosylation is not template-defined, glycosylation integrates a large series of cellular conditions such as glycosidase/glycosyltransferase abundance and activity, endoplasmic reticulum From the ‡Center

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Section: Discussionmentioning

confidence: 96%

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health

Reiding

Ruhaak

et al. 2017

Molecular & Cellular Proteomics

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“…In the state of obesity, the pro-inflammatory adipokines, derived from adipose tissue, are overexpressed, increased production, and secretion of inflammatory mediators: interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) [8,9]. The increased circulatory levels of inflammatory mediators particularly IL-6 have been associated with hepatocyte stimulation to synthesize and produce a low-grade systemic inflammation marker C-reactive protein (CRP) [8]. This protein was discovered in 1930 by Tillet and Francis, being insulated in the serum of patients with acute inflammatory processes.…”

Section: Introductionmentioning

confidence: 99%

Obesity and Its Influence on Mediators of Inflammation: Clinical Relevance of C-Reactive Protein in Obese Subjects

González‐Jiménez¹

2017

Adiposity - Omics and Molecular Understanding

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The rising prevalence of overweight and obesity in the world has been described as a global pandemic, with marked variations across countries in the levels and trends in overweight and obesity with distinct regional paterns. Concern about the health risks associated with rising obesity has become nearly universal. In this chapter, a systematic review that was conducted in four databases Web of Science, MEDLINE, Scopus, CINAHL , using the MeSH terms [obesity, inlammation, disease management, C-reactive protein CRP ] is presented. Based on the above, the aims of this work are to provide information on the relationship between obesity and circulating levels of CRP, to describe the basic chemical structure and functions, and to analyze its clinical usefulness in obese patients. The available scientiic evidence justiies the need to include determining the values of high-sensitivity C-reactive protein hs-CRP among clinical screening tests on obese subjects to evaluate the cardiovascular risk, among other risks.

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“…The development of these conditions is likely related to increased production of pro-inflammatory adipokines (e.g., interleukin 6 and tumor necrosis factor alpha) and decreased production of (or decreased tissue sensitivity to) anti-inflammatory adipokines (e.g., adiponectin). The final result is that those individuals are in an inflammatory state and show increased levels of acute phase reagents such as C-reactive protein (8) .…”

mentioning

confidence: 99%