2023
DOI: 10.1002/jcph.2305
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Obesity Considerations in Pediatric Drug Development, 2016–2021

Sherbet Samuels,
Varsha Bhatt‐Mehta,
Kyunghun Park
et al.

Abstract: Pediatric obesity is a global public health concern. Obesity‐related physiological changes may affect the pharmacokinetics of drugs and lead to therapeutic failure or toxicities. An earlier review of pediatric drug development programs from 2007 to 2016 found that, of 89 programs listing obesity‐related terms, only 4 (4%) products described pharmacokinetic changes associated with obesity. This review examined obesity considerations for 185 drug products for which pediatric drug development programs were submit… Show more

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