Obesity: epidemiology and clinical aspects

Formiguera, Xavier; Cantón, Ana

doi:10.1016/j.bpg.2004.06.030

Cited by 154 publications

(139 citation statements)

References 96 publications

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“…It is well recognized that the prevalence of obesity or overweight is much lower in Asian countries than in Western countries [47]. For example, over 70% of the Japanese subjects had a BMI <25.0 [29], while in contrast over 70% of individuals in the USA had a BMI >25.0 [48].…”

Section: Discussionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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Background: We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. Methods: One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI <22.9; overweight, BMI 23.0-24.9, and obese, BMI >25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. Results: The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. Conclusions: An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.

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Section: Discussionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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“…Adipogenesis has been studied extensively in vitro using mainly established mouse cell lines (3T3-L1, 3T3-F442A); however, there are a number of reports on isolating mesenchymal stem cells derived from bone marrow and differentiating them into adipocytes for different species, including pig (Zeng et al 2006;Zou et al 2008). Different aspects of adipogenesis have been investigated extensively since excess of adipose mass, i.e., obesity is one of the major health problems, contributing to pathogenesis of obesity-related disorders such as diabetes, hypertension, and coronary heart disease (Formiguera and Cantón 2004). The pig is considered as a model organism for the study of human obesity (Lunney 2007;Schook et al 2005).…”

Section: Communicated By T Mistelimentioning

confidence: 98%

The spatial repositioning of adipogenesis genes is correlated with their expression status in a porcine mesenchymal stem cell adipogenesis model system

2009

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Alterations in the nuclear positioning of chromosomes and specific genes during differentiation and development have suggested strongly the existence of a relationship between non-random organization of the genome and its function. In this study, we have examined the genome organization in interphase nuclei during adipogenesis, using the pig as a model organism. We hypothesized that changes in the gene expression profile and chromatin remodeling which occur during cellular differentiation would elicit repositioning of whole chromosomes, moving specific genes on them to different regions of the nucleus. We established an in vitro adipogenesis differentiation system using mesenchymal stem cells, derived from porcine bone marrow. The nuclear position of seven adipogenesis genes (PPARG, SREBF1, FABP4, CEBPA, CEBPB, CREB, and GATA2), two control genes (SOX9 and MYL1), and six chromosomes carrying these gene loci (SSC4, SSC6, SSC12, SSC13, SSC15, and SSC17) was determined. We found that during adipogenesis, using the in vitro stem cell model system, in contrast to our original hypothesis, the nuclear position of genes involved in adipogenesis was altered radically with the up-regulation of gene expression correlating with these genes becoming more internally located within nuclei. Chromosome territories, containing these genes, were also found to alter their nuclear position during the in vitro adipogenesis model, with the most dramatic repositioning being SSC4 that moved from the nuclear periphery towards the nuclear interior. We found that during in vitro adipogenesis chromosome territories decondensed and the genes were found on loops and projections of chromatin, away from the main body of the chromosomes. From our data, it appears that the temporal repositioning of genes, emanating away from chromosomes, during adipogenesis is correlated with gene activity, supporting models of the involvement of spatial genome repositioning in regulating gene expression and the nuclear interior being an important region of the nucleus for transcription.

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confidence: 99%

“…Obesity is also a major risk factor for myocardial infarction and risk of death from cancer [2,3]. Its frequency is dramatically increasing in Western countries, making it one of the major epidemics of the 21 st century [4][5][6].Surgery is usually considered for patients unable to achieve permanent weight loss by medical or dietary management if they have a body mass index (BMI) of more than 40 kg/m 2 (or more than 35 kg/m 2 and one or more obesity-related comorbidity). Surgery has been proven to be effective in the long term and can be divided into restrictive (gastroplasty, gastric banding, sleeve…”

mentioning

confidence: 99%

Safety, feasibility and weight loss after transoral gastroplasty: First human multicenter study

Devière

Valdés²,

Herrera³

et al. 2007

Surg Endosc

115

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Obesity: epidemiology and clinical aspects

Cited by 154 publications

References 96 publications

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

The spatial repositioning of adipogenesis genes is correlated with their expression status in a porcine mesenchymal stem cell adipogenesis model system

Safety, feasibility and weight loss after transoral gastroplasty: First human multicenter study

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