Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Lim, Hyungjun; Im, Keum Soon; Kim, N. H.; Kim, H. W.; Shin, Jong-Il; Sur, Jung-Hyang

doi:10.1016/j.tvjl.2015.01.005

Cited by 25 publications

(21 citation statements)

References 37 publications

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“…Obesity is described as a disease capable of influencing the mammary cancer development, progression and prognostic in women postmenopausal (Pergola and Silvestris, 2013;Howe et al, 2013) as in bitches (Perez-Alenza et al, 1998;Dolka et al, 2011;Lim et al, 2015). The absence of statistical difference in the serum concentrations of leptin, IL-6, IGF-1 and estrogen between the analyzed groups may be due the population of this study being composed of bitches diagnosed with mammary carcinoma at initial stage.…”

Section: Discussionmentioning

confidence: 86%

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Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with early stages of mammary carcinoma

Teixeira

Silva

Nunes

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to relate the serum concentration IL-6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with and without overweight, and two groups with mammary carcinomas with and without overweight. Overweight bitches, with or without mammary carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (P< 0.0001). There was a positive correlation between ECC and IMCC (P< 0.0001), ECC and % GC (P< 0.0001), and IMCC and % GC (P< 0.0001). A positive correlation was found between serum leptin and IL-6 (P= 0.0451) and leptin and IGF-1 (P= 0.05). A positive correlation (P= 0.0053) between ECC and leptin was found in the analysis of body evaluation methods and serum concentrations, and a negative correlation between ECC and IL-6 (P= 0.0435). Among the fat percentage and the leptin concentration, there was a positive correlation (P= 0.0016), as found between the IMCC and leptin (P= 0, 0209). In this study, no association was observed between excessive weight and the presence of early stage mammary carcinomas.

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Section: Discussionmentioning

confidence: 86%

“…The exact mechanism by which obesity influences cancer development and prognosis remains unknown, although factors secreted by adipocytes, including aromatase, leptin (Guo et al, 2012), adiponectin, IGF-1 (Dolka et al, 2011) and inflammatory cytokines (IL-6, TNFα), were described as important Lim et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with early stages of mammary carcinoma

Teixeira

Silva

Nunes

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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“…Regarding to breed, given the common crossbreeding of animals in Brazil, it is hard to point that some breeds are more afflicted than others due to the fact that over 50% of the animals in the study are not of a defined breed. Regarding weight, although studies point towards a relationship between obesity and the development of tumors [11], given the heterogeneity of the samples and the presence of animals without a defined breed, we could not associate weight or obesity as an important factor for the affliction of these animals due to the fact that the body score or size of the breed are not present in the history. It is important that, in the future, such information be present in the files for a better definition of this criterion.…”

Section: Discussionmentioning

confidence: 86%

“…Other factors that may be related to the onset of tumors are genetic predisposition and diet. Obese animals with diets rich in fats often present a higher risk for the development of tumors [10,11]. The onset of false pregnancies is related to the incidence of malignant tumors in canines [6].…”

Section: Epidemiologymentioning

confidence: 99%

Mammary Neoplasms in Female Dogs: Identification of Cytopathological Criteria for Malignancy

IE¹,

IM²

2015

J Cytol Histol

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Mammary neoplasms have high incidence in both women and female dogs, with such a cytological resemblance between species that studies in canines might work as a baseline for research regarding the incidence in women, due to the relatively high incidence of this cancer, similar biologic behavior, large body size, comparable responses to cytotoxic agents, and shorter overall lifespan. Given the relevance of this neoplasm and the practicality of the cytological examination, studies listing the classification criteria for these tumors gains importance, aiding in diagnosis precision. Aim and Objective: Therefore, this research paper aims at identifying and standardizing criteria that may be relevant for the diagnosis of malignancy in cytopathological preparations from mammary tumors in female canines. Once the cytopathological malignancy criteria are identified, we aim at verifying whether there is variation in the tumor's degree of aggressiveness considering the criteria established for mammary cancer in women.

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“…The expression of inflammatory mediators, adipokines and HIF-1a could be upregulated in adipose tissue, particularly in adipose stromal cells and cancer cells, and the expression of aromatase could be affected by these factors. This association could have a role in the progression of human breast cancer and CMMTs in obese subjects (van Kruijsdijk et al, 2009;Khan et al, 2013;Simpson and Brown, 2013b;Lim et al, 2015b).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Obesity-Related Factors and their Association with Aromatase Expression in Canine Malignant Mammary Tumours

Shin

Lim

Kim

et al. 2016

Journal of Comparative Pathology

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Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

Cited by 25 publications

References 37 publications

Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with early stages of mammary carcinoma

Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with early stages of mammary carcinoma

Mammary Neoplasms in Female Dogs: Identification of Cytopathological Criteria for Malignancy

Analysis of Obesity-Related Factors and their Association with Aromatase Expression in Canine Malignant Mammary Tumours

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