Obesity fosters severe disease outcomes in a mouse model of coronavirus infection associated with transcriptomic abnormalities
Pallavi Rai,
Jeffrey M. Marano,
Lin Kang
et al.
Abstract:Obesity has been identified as an independent risk factor for severe outcomes in humans with coronavirus disease 2019 (COVID‐19) and other infectious diseases. Here, we established a mouse model of COVID‐19 using the murine betacoronavirus, mouse hepatitis virus 1 (MHV‐1). C57BL/6 and C3H/HeJ mice exposed to MHV‐1 developed mild and severe disease, respectively. Obese C57BL/6 mice developed clinical manifestations similar to those of lean controls. In contrast, all obese C3H/HeJ mice succumbed by 8 days postin… Show more
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