“…By sampling a relatively endogamous population across a substantial lifestyle gradient, we show that (i) traditional, pastoralist Turkana exhibit low levels of cardiometabolic disease and (ii) increasing industrialization, in both early life and adulthood, has detrimental, additive effects on metabolic health (in opposition of popular PAR models that have rarely been tested empirically in humans) ( 20 , 22 , 24 ). Our findings offer strong support for the evolutionary mismatch hypothesis, more so than existing studies that cannot disentangle lifestyle and genetic background effects ( 6 – 12 , 44 , 45 , 46 ) or that assess lifestyle effects across much more modest gradients ( 10 , 17 , 21 , 47 , 48 ). Our work also provides some of the first multidimensional, large-scale data on acculturation and industrialization effects on cardiometabolic health in pastoralists [see also ( 34 , 49 , 50 )], which have received less attention than other subsistence modes [e.g., horticulturalists such as the Shuar and Tsimane ( 10 , 15 , 51 , 52 )].…”