Obesity impairs male fertility through long-term effects on spermatogenesis

Jia, Yanfei; Feng, Qian; Ge, Zhengyan; Guo, Ying; Zhou, Fang; Zhang, Kaishu; Wang, Xiaowei; Lü, Wei; Liu, Xiaowei; Gu, Yiqun

doi:10.1186/s12894-018-0360-5

Cited by 69 publications

(61 citation statements)

References 39 publications

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“…9 Vacuolar alterations in seminiferous tubules, spermatogenic cell dysfunction, and increased apoptosis of spermatogenic cells in testicular tissue was also observed in HFD treated rats. 23 Currently, many herbal medicines therapeutic available been recommended for the treatment of obesity. Eurycoma longifolia Jack (EL) or Tongkat Ali is a very well-known traditional medicine, EL has gained remarkable consideration in latest years because of its beneficial effects for many disorders and diseases and its strong sexual enhancing effects.…”

Section: Discussionmentioning

confidence: 99%

“…A former study has proposed mechanisms that EL has the capability to activate the steroid 17 α monooxygenase to promote the metabolism of pregnenolone and 17 hydroxy pregnenolone to yield more dehydroepiandrosterone (DHEA), 4-androstenedione, and eventually to produce testosterone. 26,23 Other investigators showed that the presence of the specific inhibitors for the cytochrome P450scc (CYP11a),17,20-lyase,17β-hydroxy-steroid-dehydrogenase(CYP17a) and calcium ion channel such as aminoglutethimide, ketoconazole and the calcium ion channel blocker, nifedipine, significantly influenced the testosterone levels. 27 EL root extract was outstanding and successful in the management of male infertility in.…”

Section: Discussionmentioning

confidence: 99%

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Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats

Al-Ani¹,

Ku-Zaifah²,

Al-Joufi³

et al. 2019

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Objective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal's testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12 th weeks and the testes samples were processed for histological examination Results: The testosterone level was significantly increased (p < 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. Conclusion: These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats

Al-Ani¹,

Ku-Zaifah²,

Al-Joufi³

et al. 2019

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“…Antioxidant enzymes include superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST). A recent study in an obese mouse model showed decreased SOD in the testicular tissues of obese rats [53].…”

Section: Effects Of Obesity On Sperm Dna Integritymentioning

confidence: 96%

Reproductive Consequences of Obesity

Hunter¹,

Hart²

2020

Obesity

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With increasing global obesity, there is a growing body of research looking at the impact of this on reproduction. Both male and female fertility are impacted on by being overweight or obese. Although the pathophysiology is not clear, it appears that obesity impacts endocrine function in men and women, oocyte and sperm quality, embryo quality, endocrine receptivity, and implantation. Miscarriage, pregnancy, and live birth rates and the risk of congenital malformations are all influenced by obesity. Transgenerational health is also affected, with metabolic, endocrine, and reproductive outcomes in the offspring being negatively affected by both paternal and maternal obesity. It appears that weight loss results in improvements in these outcomes and various strategies have been employed including lifestyle and behavior modification, pharmacological agents, and also bariatric surgery. This chapter aims to explore the reproductive outcomes of obesity and how this can be best managed to improve outcomes.

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“…The experience of male infertility is still a major public health problem represents a negative psychological burden, health costs and ostracism and social discrimination in some contexts with a strong emphasis on child-bearing. While there has been extensive focus on the female infertility, the growing body of literature suggests an correlation between male infertility and some other chronic disorders, ranging from cardiometabolic, oncologic and autoimmune disorders to increased mortality rate later in life [5][6][7][8][9]. The exact underlying pathophysiology of these associations remains unclear, although it is suggested that genetic, intrauterine environment and lifestyle factors may play a role [8,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Association Between Male Infertility and Cardiometabolic Disturbances: A Population Based Study

Behboudi‐Gandevani

Dovom

Azizi

et al. 2020

Preprint

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Aim: Studies focusing of male infertility and cardio-metabolic disorders is insufficient and controversial. The aim of this study was to evaluate the association between male infertility and cardiometabolic disturbances in a population based Tehran lipid and glucose study. Material and methods: For the purpose of the present study, we used data collected in 3rd follow up visit of Tehran Lipid and Glucose Study, which included comprehensive data on reproductive status of participants. All those who were never married, were unwillingness to have a child, had documented female infertility were excluded from the study. A total of 1611 remaining participants were further classified as two groups: men who had documented male infertility as infertile group (n = 88) and those had at least one live birth and did not have a history of primary infertility as the fertile group (n = 1523). Generalized Linear Regression model (GLM) with logit link were applied to assess the to explore the association between male infertility and cardiometabolic disturbances including diabetes mellitus, pre-diabetes, hypertension, metabolic syndrome, dyslipidemia, obesity, central obesity and chronic kidney disease after further adjustment for age and BMI.Results: Compared to fertile controls, infertile men were more likely to be older, [58 (13.3) versus 53 (10.2) years (P = 0.003)]. The results of unadjusted model revealed that infertility were significantly associated with hypertension and CKD, OR = 1.8 (95%CI: 1.2, 2.9, P-value = 0.006) and OR = 1.9 (95%CI: 1.1, 3.6, P-value = 0.033), respectively. However, the significant association, which were found in crude analyses, were disappeared after adjusting for potential confounders of age and BMI. Moreover, infertility did not have any association with other cardiometabolic disturbances including diabetes and pre-diabetes, metabolic syndrome, dyslipidemia, obesity and central obesity in unadjusted and adjusted analysis. Conclusion: Our study revealed that there were not any association between male infertility and cardiometabolic disturbances in a population based setting. This study is an incentive to initiate more explicit surveys concerning this topic in order to provide more accurate data on male infertility. More population-based studies with large sample size are still warranted to confirm these findings.

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Obesity impairs male fertility through long-term effects on spermatogenesis

Cited by 69 publications

References 39 publications

Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats

Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats

Reproductive Consequences of Obesity

The Association Between Male Infertility and Cardiometabolic Disturbances: A Population Based Study

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