Obesity in Cancer Survival

Parekh, Niyati; Chandran, Urmila; Bandera, Elisa V.

doi:10.1146/annurev-nutr-071811-150713

Cited by 159 publications

(129 citation statements)

References 107 publications

(236 reference statements)

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…This may have resulted in a variation in the body composition response to the exercise training and contributed to the nonsignificant effect of the intervention on this aspect of health-related physical fitness. Because of the potential association of poor body composition with negative disease and survival outcomes in CRC survivors (Parekh et al 2012), future research may consider interventions with larger samples with greater statistical power to detect body composition changes and allow for subgroup analyses; with a greater volume of exercise; that are longer in duration; and (or) that are combined with reduced caloric intake to maximize changes in body composition.…”

Section: Discussionmentioning

confidence: 99%

“…Some research has also suggested that poor body composition (i.e., obese and overweight) negatively affects CRC recurrence and survival (Parekh et al 2012). Unfortunately, CRC survivors have the highest levels of inactivity (60%) among Canadian cancer survivors, and over half of these individuals are either overweight (39%) or obese (17%) (Courneya et al 2008b).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility and efficacy of a 12-week supervised exercise intervention for colorectal cancer survivors

Sellar

Bell

Haennel

et al. 2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

Exercise training improves health-related physical fitness and patient-reported outcomes in cancer survivors, but few interventions have targeted colorectal cancer (CRC) survivors. This investigation aimed to determine the feasibility and efficacy of a 12-week supervised exercise training program for CRC survivors. Feasibility was assessed by tracking participant recruitment, loss to follow-up, assessment completion rates, participant evaluation, and adherence to the intervention. Efficacy was determined by changes in health-related physical fitness. Over a 1-year period, 72 of 351 (21%) CRC survivors screened were eligible for the study and 29 of the 72 (40%) were enrolled. Two participants were lost to follow-up (7%) and the completion rate for all study assessments was ≥93%. Mean adherence to the exercise intervention was 91% (standard deviation = ±18%), with a median of 98%. Participants rated the intervention positively (all items ≥ 6.6/7) and burden of testing low (all tests ≤ 2.4/7). Compared with baseline, CRC survivors showed improvements in peak oxygen uptake (mean change (MC) = +0.24 L·min(-1), p < 0.001), upper (MC = +7.0 kg, p < 0.001) and lower (MC = +26.5 kg, p < 0.001) body strength, waist circumference (MC = -2.1 cm, p = 0.005), sum of skinfolds (MC = -7.9 mm, p = 0.006), and trunk forward flexion (MC = +2.5 cm, p = 0.019). Exercise training was found to be feasible and improved many aspects of health-related physical fitness in CRC survivors that may be associated with improved quality of life and survival in these individuals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Feasibility and efficacy of a 12-week supervised exercise intervention for colorectal cancer survivors

Sellar

Bell

Haennel

et al. 2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

show abstract

“…American Cancer Society (ACS) estimates that 29% of all newly diagnosed malignant disease will be breast cancer and it will be cause in 16% of the deaths (Parekh et al, 2012;Siegel et al, 2012;Taghavi et al, 2012). Increased number of survivors after diagnosis of breast cancer suggests that modifiable risk factors that can improve remission, survival and quality of life should have to be investigated (Malcolm et al, 2009;Klimant et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Relationship of Body Mass Index with Prognosis in Breast Cancer Patients Treated with Adjuvant Radiotherapy and Chemotherapy

Cihan¹

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The aim of this study was to investigate the relationship of body mass index with overall and progression-free survival as well as other prognostic factors of breast cancer in patients with non-metastatic breast cancer. Materials and Methods: We retrospectively reviewed 456 patients diagnosed with breast cancer in the Radiation Oncology department of Kayseri Teaching Hospital between 2005 and 2013. We investigated relationship of body mass index with prognosis and other prognostic factors. Results: The study included 456 patients (447 women and 9 men). Mean age at presentation was 55.6 years. Of the cases, 96.9% underwent modified radical mastectomy and 95.0% received chemotherapy, while 82.4% received radiotherapy and 60.0% were given hormone therapy. Body mass index was >25 mg/kg 2 in 343 cases. Five-and 10-years overall survival rates were 77% and 58% whereas progression-free survival rates were 65% and 49%, respectively. In univariate analyses, factors including stage (p=0.046), tumor diameter (p=0.001), lymph node metastasis (p=0.006) and body mass index (p=0.030) were found to be significantly associated with overall survival, while perinodal involvement was found to be significantly associated with progression-free survival (p=0. RESEARCH ARTICLE Relationship of Body Mass Index with Prognosis in Breast Cancer Patients Treated with Adjuvant Radiotherapy and Chemotherapy Yasemin Benderli CihanThe aim of this study was to investigate whether BMI at diagnosis have prognostic value in breast cancer patients who underwent surgery. Materials and Methods Patient group and demographic characteristicsWe retrospectively reviewed operated breast cancer patients who were followed in Radiation Oncology department of Kayseri Teaching Hospital between 2005 and 2013. Patients with missing data and those lost in followup were excluded from analysis. The study was planned in accordance to local ethics regulations and Helsinki Declaration. We reviewed age, gender, menopausal status, family history of breast cancer, height, weight, BMI, tumor localization, tumor stage, surgery type, histopathological findings, data regarding chemotherapy and radiotherapy, and survival times. In the histopathological diagnosis, tumor type, tumor localization, tumor diameter, lymphatic metastasis, number of lymph nodes excised, number of lymph nodes with metastatic infiltration, level of estrogen and progesterone receptors, cerb-B2 status, grade, and Yasemin Benderli Cihan

show abstract

“…2003; Parekh et al. 2012). While this association appears to be strong in postmenopausal women (Xia et al.…”

Section: Introductionmentioning

confidence: 99%

Voluntary physical activity counteracts the proliferative tumor growth microenvironment created by adipose tissue via high-fat diet feeding in female rats

Theriau

Connor

2017

Physiol Rep

View full text Add to dashboard Cite

The adipokine secretion profile created from adipose tissue may represent the molecular mechanism behind the obesity‐breast cancer association. Two adipokines, adiponectin (ADIPO), and leptin (LEP), are altered with obesity and exert antagonistic effects on breast cancer proliferation. We set out to determine whether the adipose‐dependent tumor promoting growth environment created by a high‐fat diet (HFD) in female Sprague‐Dawley rats is altered compared to established responses in male rats and whether voluntary physical activity (PA) ameliorates any HFD‐dependent effects. We found that conditioned media (CM) created from the adipose tissue of female HFD‐fed rats increased the proliferation of MCF7 cells compared to those cells grown in CM prepared from lean adipose tissue. HFD‐CM inhibited AMPK and activated Akt signaling, decreased p27 phosphorylation at T198, reduced total p27 and AdiporR1 protein levels and promoted cell‐cycle entry. PA reversed the proliferative effects of HFD‐CM on MCF7 cells by preventing the effects of HFD on AMPK, Akt, p27 and AdipoR1, ultimately resulting in cell‐cycle withdrawal. Overexpressing AdipoR1 abolished the proliferative effects of the HFD‐CM on MCF7 cells and enhanced the anti‐proliferative effects PA on the HFD‐CM. Thus, PA represents a means to prevent deleterious obesity‐related alterations in tumor growth environment which are brought about by changes in adipokine secretion profile from adipose tissue in the presence of estrogen. Furthermore, although adipose produces hundreds of adipokines, the ADIPO:LEP ratio may serve to indicate the contribution of adipose in creating a tumor growth microenvironment.

show abstract

Obesity in Cancer Survival

Cited by 159 publications

References 107 publications

Feasibility and efficacy of a 12-week supervised exercise intervention for colorectal cancer survivors

Feasibility and efficacy of a 12-week supervised exercise intervention for colorectal cancer survivors

Relationship of Body Mass Index with Prognosis in Breast Cancer Patients Treated with Adjuvant Radiotherapy and Chemotherapy

Voluntary physical activity counteracts the proliferative tumor growth microenvironment created by adipose tissue via high-fat diet feeding in female rats

Contact Info

Product

Resources

About