Obesity in Mexico: prevalence, comorbidities, associations with patient outcomes, and treatment experiences

DiBonaventura, Marco; Meincke, Henrik H.; Lay, A Le; Fournier, Janine; Bakker, Erik Jan; Ehrenreich, A

doi:10.2147/dmso.s129247

Cited by 58 publications

(56 citation statements)

References 48 publications

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“…The prevalence of overweight and obesity in Mexico is among the highest in the world [27]. In 2016, the National Survey of Health and Nutrition (ENSANUT) determined that an estimated 72.5% of Mexican adults are overweight or obese [28], and that growth in the prevalence of obesity had plateaued in urban areas but continues to rise in rural areas [28].…”

Section: Introductionmentioning

confidence: 99%

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

et al. 2020

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To determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers. Methods Participants in the Mexican Health Worker Cohort Study with complete information at two waves of data collection, 2004-2006 (W1) and 2011-2013 (W2), were included in the analysis (n = 1,174). Multivariable binary and multinomial logistic regression were used to examine the cross-sectional associations between specific risk factors and diabetes status (diabetes, pre-diabetes, or neither) at W1 and the longitudinal associations between changes in risk factors and progression of diabetes status from W1 to W2, respectively. Results Mean time between waves was 7.0 years (SD 1.1). Prevalence of pre-diabetes and diabetes was 16% and 10% at W1 and increased to 30% and 16% at W2, respectively. The crosssectional prevalence of pre-diabetes and diabetes was significantly higher among men, participants over the age of 45 years, and individuals who were overweight or obese or had metabolic syndrome (MS), three or more components of the MS, elevated alanine aminotransferase (ALT) levels, or elevated uric acid. In longitudinal analyses, remaining obese or gaining weight between waves was associated with an increased risk of developing pre-diabetes. A greater risk of developing pre-diabetes or diabetes was also observed among

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Section: Introductionmentioning

confidence: 99%

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

et al. 2020

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“…25 In Mexico, the prevalence of obese or overweight people reported in 2017 was 62%. 3 Some authors showed that prevalence is expected to increase to 88% for men and 91% for women for 2050. 26 In the present study, we found 75% prevalence of overweight and obesity in women and 76% in men.…”

Section: Discussionmentioning

confidence: 99%

“…2 It was previously reported that 62% of Mexican adults are at least overweight. 3 Adipose tissue is considered an important endocrine organ with high lipid storage capacity for systemic management of energy substrates. Excessive lipid loading produces adipocyte stress with the ability to cause adverse effects on obesity.…”

Section: Introductionmentioning

confidence: 99%

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

García-Sánchez

Gámez-Nava

Cruz

et al. 2020

DMSO

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Purpose: The increase of visceral abdominal fat (VAF) and oxidative stress (OS) are independent predictors for cardiovascular risk. This study aimed to determine the association of VAF with proinflammatory cytokines, oxidants, antioxidants, and oxidative damage to DNA in subjects with normal weight, overweight, and obesity. Patients and Methods: A cross-sectional study that included 21 men and 71 women who attended for a medical check-up was conducted. Dual-energy X-ray absorptiometry (DXA) was used to measure the VAF volume. ELISA and colorimetric techniques were used for chemical analysis.Results: Low activity of superoxide dismutase (SOD) was found in overweight and obese subjects compared to the normal weight group (p=0.005). In contrast, the activity of glutathione peroxidase (GPx) was higher in the overweight and obesity groups compared to the normal weight subjects (p=0.017). The total antioxidant capacity (TAC) was also increased in the overweight group compared to the normal weight group (p=0.04). According to the volume of VAF, the levels of tumor necrosis factor alfa and interleukin 6 showed no differences between subjects with normal and high VAF. Subjects with high VAF show higher levels of 8-isoprostans compared to normal VAF group (p=0.039). Less concentration of 8-oxoguanine-DNA-N-glycosylase-1 (hOGG1) was found in the high VAF group (p=0.032) compared to the normal VAF subjects. VAF was positively correlated with lipoperoxides (LPO) (r=0.27, p<0.05) and 8-isoprostanes (r=0.25, p<0.05). We also found correlations between oxidative stress markers and anthropometric ratios for intra-abdominal fat. The waist-hip ratio was positively correlated with LPO (r=0.30, p<0.05) and TAC (r=0.24, p<0.05). Conclusion: These findings suggest that the predominantly oxidative damage associated with VAF in overweight or obesity is lipoperoxidation and oxidative DNA damage. Alterations in endogenous antioxidant defenses may not be linked to the amount of VAF.

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“…Mexico is among the most negatively affected countries by obesity-related comorbidities. Given the accelerated increase of chronic diseases worldwide, it is essential to take action to address this health problem [39]. In this focused study, the nutritional practices of a speci c Mexican population were examined with an intent to elucidate a possible adiponectin association with nutritional and sociodemographic characteristics in young students from the Los Altos, Jalisco region of Mexico.…”

Section: Discussionmentioning

confidence: 99%

Cross-Sectional Association of Adiponectin with Sociodemographic and Nutrition-Related Factors in Mexican Students from the Los Altos, Jalisco Region

González-Torres

González-Silva

Perez-Reyes

et al. 2020

Preprint

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Abstract Background Adiponectin is a biomarker useful for the early diagnosis of obesity-related comorbidities. The Mexican population has one of the highest obesity rates worldwide. The purpose of this study was to determine whether an association exists between adiponectin and certain sociodemographic and nutrition-related factors in young adults. This is perhaps one of only a few studies focused in the Los Altos, Jalisco area, a center for religious and cultural traditions in Mexico. Methods A cross-sectional analysis was conducted from January to November 2019 at the Los Altos University Center. A total of 173 student volunteers participating in the study provided voluntary signed, written consent forms. Sociodemographic data were collected. Biochemical and nutritional assessments were realized after eight hours of fasting. Dietary questionnaires were analyzed using Nutrikcal® software. Total serum adiponectin levels were quantified by enzyme-linked immunosorbent assay. Correlations and multivariate models were computerized by SPSSv20. This research project was approved and registered by the Research and Bioethics Committee of the Los Altos University Center, Mexico. Results According to body mass index (BMI), the incidence of underweight participants was found to be 10.4%, whereas that for overweight and obese patients combined was found to be 23.1%. A positive correlation of serum adiponectin levels was found in the following categories: female gender (r = 0.353, p = 0.01); high-density lipoprotein cholesterol (HDL-c) (r = 0.487, p = 0.01); and fruit intake (r = 0.204, p = 0.031). Multivariate analysis showed that 41.6% of adiponectin levels measured could be explained by gender, glucose, HDL-c, sodium and ascorbic acid consumption (r2 = 0.416, p < 0.01). Conclusions In accordance with the results, the incidence of underweight participants was greater than that expected as contrasted by national reports generated in Mexico. In addition, adiponectin level was found to vary with gender and nutrition-related factors. Further studies should be performed in this population to assess the role of religious and Mexican cultural traditions on health status in an effort to prevent undernutrition and obesity-related morbidity and mortality.

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Obesity in Mexico: prevalence, comorbidities, associations with patient outcomes, and treatment experiences

Cited by 58 publications

References 48 publications

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

Cross-Sectional Association of Adiponectin with Sociodemographic and Nutrition-Related Factors in Mexican Students from the Los Altos, Jalisco Region

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