Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States

Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes

“…This might be explained by the observation that pump therapy may deliver fasting and prandial insulin doses in a more physiological manner than injection-based therapy [16]. Recent data indicate that about one-third of children and adolescents with Type 1 diabetes are overweight or obese, similar to the general paediatric population [29,30]. In the present study, from first to last observation, overweight/obesity increased from 31% to 49%.…”

Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study

“…CVD-related morbidity and mortality are markedly increased in individuals with T1D (1, 2), with 17 years of life lost when T1D is diagnosed at age 10 (12). Obesity is an increasingly prevalent problem in youth with T1D (13) and linked to CVD development (14). Obesity induces a progressive resistance to the anorexigenic effects of leptin, which promotes further weight gain and metabolic dysfunction (15).…”

Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review

“…For example, the Diabetes-Patienten-Verlaufsdokumentation (DPV) registry reported hypercholesterolemia in 29% of youth with T1DM (72, 73), and T1DM Exchange data demonstrated elevated LDL-C in 28% of youth with T1DM with suboptimal glycemic control (74). The higher prevalence of dyslipidemia in youth compared to adults with T1DM is likely attributable to worse glycemic control, higher rates of obesity (75) and lower insulin sensitivity in adolescents (76, 77). …”