Obesity increases the risk of small intestinal bacterial overgrowth (<scp>SIBO</scp>)

Roland, Bani Chander; Lee, D.; Miller, Larry S.; Vegesna, Anil K.; Yolken, Robert H.; Severance, Emily G.; Prandovszky, Emese; Zheng, Xi; Mullin, Gerard E.

doi:10.1111/nmo.13199

Cited by 43 publications

(34 citation statements)

References 39 publications

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“…Another association between obesity and FGID is the gut microbiota. Increased risk of small intestinal bacterial overgrowth (28) and different gut microbiota composition (29) in obesity has been reported which might contribute to gastrointestinal dysmotility, excessive fermentation, altered visceral perception and gut permeability with their metabolites leading to pain-predominant FGID (30,31). Finally, obesity and FGID share common psychological comorbidities, such as stress, depression, and anxiety, which can contribute to each other's development and aggravate each other (32,33,34).…”

Section: Discussionmentioning

confidence: 99%

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

Galai

Moran‐Lev

Cohen³

et al. 2020

Preprint

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Background Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal disorders in children. We aimed to define the association between obesity and functional abdominal pain (FAP) disorders and to assess differences between overweight/obese children and normal weight children with FAP disorders. Methods We conducted a retrospective study of children (2-18 years old) with a clinical diagnosis of FAP who were followed-up in our pediatric gastroenterology unit between 1/2016-10/2018. FAP disorders were defined according to the ROME IV criteria. Body mass index (BMI) percentiles were defined by CDC standards. Patients with BMIs ≥85th percentile were designated as being overweight/obese. A population control group was obtained from the 2015-2016 Israel national health survey. Results Data from 173 children with FAP disorders (median age 11.5 years, 114 females) were included. Seventy-one children (41%) were classified as having functional abdominal pain-NOS, 67 (38.7%) as having irritable bowel syndrome (IBS), and 35 (20.2%) has having functional dyspepsia. Fifty-three children (30.6%) were classified as being overweight/obese. Adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04). Children with FAP and overweight were older [12.4 (range 9.8-15.3) vs. 10.8 (7.4-14.1) years, p = 0.04] and had more hospitalizations due to FAP (20.8% vs. 7.6%, p = 0.01) compared to Children with FAP and normal weight. Conclusions Adolescents with FAP had higher prevalence of overweight/obesity compared to controls. Future studies are warranted to raise awareness of weight issues in FAP and determine the effect of weight loss on FAP.

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Section: Discussionmentioning

confidence: 99%

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

Galai

Moran‐Lev

Cohen³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…PPIs increase gastric pH, which disrupts the native GI microecosystem 12. PPI use has been previously associated with a decrease in lower GI tract microbial diversity; however, the clinical relevance of these findings is unclear 57. A recent twin study comparing concordance of leanness or obesity found that obesity was associated with a significant reduction in overall GI tract bacterial diversity 58.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic and acid-suppression medications during early childhood are associated with obesity

Stark

Susi

Emerick

et al. 2018

Gut

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ObjectiveGut microbiota alterations are associated with obesity. Early exposure to medications, including acid suppressants and antibiotics, can alter gut biota and may increase the likelihood of developing obesity. We investigated the association of antibiotic, histamine-2 receptor antagonist (H2RA) and proton pump inhibitor (PPI) prescriptions during early childhood with a diagnosis of obesity.DesignWe performed a cohort study of US Department of Defense TRICARE beneficiaries born from October 2006 to September 2013. Exposures were defined as having any dispensed prescription for antibiotic, H2RA or PPI medications in the first 2 years of life. A single event analysis of obesity was performed using Cox proportional hazards regression.Results333 353 children met inclusion criteria, with 241 502 (72.4%) children prescribed an antibiotic, 39 488 (11.8%) an H2RA and 11 089 (3.3%) a PPI. Antibiotic prescriptions were associated with obesity (HR 1.26; 95% CI 1.23 to 1.28). This association persisted regardless of antibiotic class and strengthened with each additional class of antibiotic prescribed. H2RA and PPI prescriptions were also associated with obesity, with a stronger association for each 30-day supply prescribed. The HR increased commensurately with exposure to each additional medication group prescribed.ConclusionsAntibiotics, acid suppressants and the combination of multiple medications in the first 2 years of life are associated with a diagnosis of childhood obesity. Microbiota-altering medications administered in early childhood may influence weight gain.

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“…Another association between obesity and FGID is the gut microbiota. Increased risk of small intestinal bacterial overgrowth (28) and different gut microbiota composition (29) in obesity has been reported which might contribute to gastrointestinal dysmotility, excessive fermentation, altered visceral perception and gut permeability with their metabolites leading to painpredominant FGID (30,31). Finally, obesity and FGID share common psychological comorbidities, such as stress, depression, and anxiety, which can contribute to each other's development and aggravate each other (32,33,34).…”

Section: Discussionmentioning

confidence: 99%

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

Galai

Moran‐Lev

Cohen³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal disorders in children. We aimed to define the association between obesity and functional abdominal pain (FAP) disorders and to assess differences between overweight/obese children and normal weight children with FAP disorders. Methods: We conducted a retrospective study of children (2-18 years old) with a clinical diagnosis of FAP who were followed-up in our pediatric gastroenterology unit between 1/2016-10/2018. FAP disorders were defined according to the ROME IV criteria. Body mass index (BMI) percentiles were defined by CDC standards. Patients with BMIs ≥85th percentile were designated as being overweight/obese. A population control group was obtained from the 2015-2016 Israel national health survey. Results: Data from 173 children with FAP disorders (median age 11.5 years, 114 females) were included. Seventy-one children (41%) were classified as having functional abdominal pain-NOS, 67 (38.7%) as having irritable bowel syndrome (IBS), and 35 (20.2%) has having functional dyspepsia. Fifty-three children (30.6%) were classified as being overweight/obese. Adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04). Children with FAP and overweight were older [12.4 (range 9.8-15.3) vs. 10.8 (7.4-14.1) years, p = 0.04] and had more hospitalizations due to FAP (20.8% vs. 7.6%, p = 0.01) compared to Children with FAP and normal weight. Conclusions: Adolescents with FAP had higher prevalence of overweight/obesity compared to controls. Future studies are warranted to raise awareness of weight issues in FAP and determine the effect of weight loss on FAP.

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Obesity increases the risk of small intestinal bacterial overgrowth (SIBO)

Abstract: While obesity was significantly associated with SIBO, our findings suggest that alterations in gut pH, SBTT, and decline in species richness do not account for the obesity-SIBO relationship.

Cited by 43 publications

References 39 publications

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

Antibiotic and acid-suppression medications during early childhood are associated with obesity

Higher Prevalence of Obesity among Children with Functional Abdominal Pain Disorders

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