Obesity indices and inflammatory markers in obese non-diabetic normo- And hypertensive patients. a comparative pilot study

Stepień, M; Stępień, Agnieszka; Wlazeł, Rafał Nikodem; Paradowski, Marek; Banach, Maciej; Rysz, Jacek

doi:10.1016/j.atherosclerosis.2014.05.382

Cited by 26 publications

(34 citation statements)

References 35 publications

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“…14 Obesity which is a feature of metabolic syndrome was associated with chronic inflammation in obese subjects. 15 In the current study, there is a significant positive correlation of hs-CRP and Total Cholesterol, LDL-C, Triacylglycerol. This is supported by the study done by Mahmoud et al 16 Serum HDL-C was not significantly correlated with hs-CRP.…”

Section: Discussionsupporting

confidence: 52%

Serum high sensitivity C reactive protein and lipid profile in obese students

2019

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Background: The prevalence of overweight and obesity is progressively increasing in younger and adult population in India. It is a medical problem that increases risk of other diseases and health problems, such as heart disease, diabetes, high blood pressure and certain cancers. One of the causes of dyslipidaemia is obesity. High sensitivity C-Reactive Protein (hs-CRP), is a marker of systemic inflammation and a predictor of type 2 diabetes and cardiovascular disease. Hence it is important to check the relationship of hs-CRP with lipid profiles in obese and non-obese students.Methods: A case control observational study was carried out in 60 students. They were divided in to two groups obese and non-obese based on the BMI ranges. Serum lipid levels, hs-CRP and BMI was estimated in both groups to find out correlation of hs-CRP with lipid profile and BMI.Results: There was a significant rise in serum Total Cholesterol, LDL-C, Triacylglycerol and a significant fall in HDL-C in obese group as compared to non-obese group. Serum hs-CRP and BMI was significantly increased in obese students as compared to non-obese students. There was statistically significant positive correlation found between hs-CRP and total cholesterol, LDL-C, Triacylglycerol in obese students.Conclusions: Significant correlation was found between hs-CRP and lipid profile except HDL-C. Serum hs-CRP levels may decrease by treatment of dyslipidaemia. This would minimize the incidence of atherosclerosis and hence decrease the risk for development of coronary artery disease. Hence, improving the quality of life.

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Section: Discussionsupporting

confidence: 52%

Serum high sensitivity C reactive protein and lipid profile in obese students

2019

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“…We found that the circulatory CRP levels were also elevated in obesity. The present data showing the increased IL-18/CRP expression in obesity are in agreement, at least in part, with previous reports [27][28][29][30][31][32][33].…”

Section: Discussionsupporting

confidence: 94%

Increased Adipose Tissue Expression of Toll-Like Receptor (TLR)-7 in Obese Individuals: Significance in Metabolic Disease

Sindhu

Wilson

Akhter

et al. 2015

Journal of Glycomics & Lipidomics

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Purpose: Toll-like receptors (TLRs) are the innate immune receptors and some are now found to be involved in metabolic inflammation. TLR4 and TLR2 expressed on cell surface have emerged as immunometabolic receptors, however, the status of endocytic TLRs, especially TLR7 in metabolic disease remains unclear. Therefore, we investigated the adipose tissue expression of TLR7 in obese individuals. Methods: For this purpose, biopsy samples of periumbilical (subcutaneous) fat were collected from 49 individuals classified based on body mass index (BMI) as 22 obese (BMI=34.13 ± 2.81 kg/m 2), 18 overweight (BMI=28.26 ± 1.20 kg/ m 2), and 9 lean (BMI=22.61 ± 2.40 kg/m 2) subjects. Expression of the TLR7, TLR-signaling components (MyD88, IRAK1, and TRAF6), macrophage markers (CD68 and CD11c), and inflammatory cytokine (IL-18) was determined by quantitative real-time RT-PCR. Systemic inflammatory marker (C-reactive protein) plasma concentrations were determined by commercial ELISA kit. Data were analyzed using t-test and Pearson's correlation (r). Results: We found that TLR7 mRNA expression was significantly upregulated in obese (P=0.028) and overweight (P=0.043) as compared with lean individuals; this increase correlated with BMI (r=0.35 P=0.014) and body fat percentage (r=0.39 P=0.

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“…Obesity is associated with chronic inflammation owing to NEFA-induced activation of inflammatory pathways (82,83) . This inflammatory response leads to increased extracellular matrix synthesis but reduced extracellular matrix degradation, resulting in increased deposition and remodelling of extracellular matrix, especially in adipocytes (84,85) .…”

Section: Inflammation Extracellular Matrix and Bone Metabolism-relatmentioning

confidence: 99%

The impact of genetic polymorphisms on weight regain after successful weight loss

2020

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Abstract Obesity is associated with an increased risk of various diseases and mortality. Although nearly 50 % of adults have been reported trying to lose weight, the prevalence of obesity has increased. One factor that hinders weight loss-induced decrease in obesity prevalence is weight regain. Although behavioural, psychological and physiological factors associated with weight regain have been reviewed, the information regarding the relationship between weight regain and genetics has not been previously summarised. In this paper, we comprehensively review the association between genetic polymorphisms and weight regain in adults and children with obesity after weight loss. Based on this information, identification of genetic polymorphism in patients who undergo weight loss intervention might be used to estimate their risks of weight regain. Additionally, the genetic-based risk estimation may be used as a guide for physicians and dietitians to provide each of their patients with the most appropriate strategies for weight loss and weight maintenance.

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Obesity indices and inflammatory markers in obese non-diabetic normo- And hypertensive patients. a comparative pilot study

Cited by 26 publications

References 35 publications

Serum high sensitivity C reactive protein and lipid profile in obese students

Serum high sensitivity C reactive protein and lipid profile in obese students

Increased Adipose Tissue Expression of Toll-Like Receptor (TLR)-7 in Obese Individuals: Significance in Metabolic Disease

The impact of genetic polymorphisms on weight regain after successful weight loss

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