Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population

Rajendran, Karthick; Devarajan, Nalini; Manohar, G.; Ragunathan, Malathi

doi:10.1186/1477-9560-10-13

Cited by 35 publications

(22 citation statements)

References 24 publications

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“…Consistent with this report, Rajendran et al [65] measured leptin levels, high-sensitivity C Reactive protein (hs-CRP) and IL-6 levels in patients with acute myocardial infarction (AMI), showing higher levels of leptin than control subjects.…”

Section: Leptinsupporting

confidence: 61%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

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Obesity has become an important public health issue in Western and developing countries, with well known metabolic and cardiovascular complications. In the last decades, evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences. As a consequence of the expansion of fat depots, in obese subjects, adipose tissue cells develope a phenotypic modification, which turns into a change of the secretory output. Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling, vascular biology and, moreover, participate to the systemic inflammatory response, which characterizes obesity and metabolic syndrome. This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events. A great number of adipocytokines have been described recently, linking inflammatory mileu and vascular pathology. The understanding of these pathways is crucial not only from a pathophysiological point of view, but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets. The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. Key words: Adipocytokines; Obesity; Metabolic syndrome; Coronary artery disease; Inflammation Core tip: Our article, provide a comprehensive review of the evidence about adipose tissue and cardiovascular risk, focusing on the pathophysiological and clinical role of fat-derived mediators, the so-called adipocytokines.

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Section: Leptinsupporting

confidence: 61%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

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“…Ceruloplasmin is an inflammation sensitive marker as well as an acute phase protein which is measured clinically. 10 Sarkar et al found negative correlation of fasting plasma glucose with antioxidants like ceruloplasmin in type 2 diabetes mellitus patient. It indicated increased glycation of protein that may damage antioxidant protein like ceruloplasmin.…”

Section: Discussionmentioning

confidence: 99%

Serum Ceruloplasmin levels in Type 2 Diabetes mellitus – Assessing the cardiovascular risk

Indra

Sivaranjani²,

Rajalakshmi³

et al. 2019

IJMBS

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Type 2 diabetes mellitus is an endocrinological disease associated with hyperglycemia characterized by both insulin resistance and defective insulin secretion. Cardiovascular diseases are the peak reason for mortality in India, highest rate seen in Tamil Nadu state, from the age of 25 to 69 years. Many studies have revealed the importance of inflammatory pathway playing a pivotal role in the development and progression of diabetic complications. Ceruloplasmin, a copper containing mettalo-enzyme having antioxidant property (e.g ferroxidase activity) is an ideal marker to know the cardiovascular status, glycemic status, dyslipidemia and cancer risk. The purpose of the present study was to evaluate the effects of Body Mass Index (BMI) and Ceruloplasmin levels on the incidence of cardiovascular diseases in Type 2 Diabetes mellitus patients. Fasting Blood glucose, lipid profile which includes serum triglyceride, total cholesterol, LDL, VLDL, HDL and serum ceruloplasmin were investigated using fully automated chemistry analyzer. Diabetic patients were segregated into three groups based on their BMI, which was correlated with inflammatory marker ceruloplasmin to assess the cardiovascular risk. The mean value and standard deviation of ceruloplasminin controls (n=60) and diabetic cases divided into normal weight, over weight and obese (n=20 each) were 38.3±8.45, 36±7.99, 33.2±3.57and34.2±6.24 mg/dl respectively. Ceruloplasmin among the cases and controls were not statistically significant. Serum ceruloplasmin levels and BMI showed no correlation among the group 1 diabetic cases and was not significant (p=0.29), among the group 2diabetic cases it showed weak correlation and was not significant (p=0.85), and it also showed no correlation among the group 3 diabetic cases and was not significant (p=0.65).This study revealed no significant association between serum ceruloplasmin level and BMI in all diabetic group subjects separately.

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“…It has been proposed that inflammatory cytokines, secreted by adipose tissue, exert an endocrine effect with insulin resistance in liver, skeletal muscle, and vascular endothelial tissue, leading to T2DM and cardiovascular disease [2]. It has been proposed that inflammatory cytokines, secreted by adipose tissue, exert an endocrine effect with insulin resistance in liver, skeletal muscle, and vascular endothelial tissue, leading to T2DM and cardiovascular disease [2].…”

Section: Text Of Reviewmentioning

confidence: 99%

“…Production is stimulated by cytokines, proteins with endocrine and metabolic functions [2,3], of the innate immune response, mainly interleukin 6 (IL-6) and tumor necrosis factor (TNF-a). Production is stimulated by cytokines, proteins with endocrine and metabolic functions [2,3], of the innate immune response, mainly interleukin 6 (IL-6) and tumor necrosis factor (TNF-a).…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6 and obesity

El-Kadre

Tinoco²

2013

Current Opinion in Clinical Nutrition and Metabolic Care

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IL-6 displays pleiotropic functions in a tissue-specific and physiological context-dependent manner. There is evidence suggesting that IL-6 worsens insulin resistance in the liver and adipose tissue, while improving insulin sensitivity in the muscle. The effects of this cytokine are influenced by its acute or chronical presence, the latter being associated with insulin resistance. IL-6 has anti-inflammatory effects and a compensatory role in obesity by increasing islet GLP-1 production. The therapeutic approach of blocking IL-6 signal can be diabetogenic.

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Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population

Cited by 35 publications

References 24 publications

Adipose tissue and vascular inflammation in coronary artery disease

Adipose tissue and vascular inflammation in coronary artery disease

Serum Ceruloplasmin levels in Type 2 Diabetes mellitus – Assessing the cardiovascular risk

Interleukin-6 and obesity

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