Obesity, inflammation, and kidney disease

Navarro-Díaz, Maruja; Serra, Assumpta; López, Dolores; Granada, Marisa; Bayés, Beatriz; Romero, R.

doi:10.1038/ki.2008.518

Cited by 40 publications

(26 citation statements)

References 28 publications

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“…However, it is important to underline that the association between high BMI and CKD has been debated. Indeed, while results of some studies [8,21,22,23,24,25,26,27,28] are in keeping with those of the present one, BMI was not responsible for progression of CKD in diabetic patients [7] and no difference was observed in the rate of annual progression of estimated GFR comparing normal, overweight, and obese nondiabetic patients with stage 3 CKD [29]. …”

Section: Discussionsupporting

confidence: 64%

Impact of BMI on Cardiovascular Events, Renal Function, and Coronary Artery Calcification

Russo

Morrone²,

Errichiello³

et al. 2014

Blood Purif

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Background/Aims: High BMI increases the risk of cardiovascular events (CVEs) in the general population. Conflicting results have been reported on the role of BMI on CVEs and on decline of renal function in patients with chronic kidney disease not on dialysis (CKD). This study evaluates the impact of BMI on CVEs, dialysis initiation, and coronary artery calcification (CAC) in CKD patients. Methods: CKD patients were divided in normal-BMI and high-BMI patients. CVEs, initiation of dialysis, and extent and progression of CAC were assessed. Univariate and multivariable analysis were performed (adjustment variables: age, diabetes, hypertension, gender, CKD stage, serum concentration of hemoglobin, parathyroid hormone, calcium, phosphorus, albumin, C-reactive protein, LDL-cholesterol, total calcium score, 24-hour proteinuria). Patients were followed to the first event (CVE, dialysis) or for 2 years. Results: 471 patients were evaluated. A CVE occurred in 13.5 and 21.3% (p < 0.05) of normal-BMI and high-BMI patients, respectively. High BMI did not increase the risk for CVEs in univariate (HR: 1.86; 95% CI: 0.97-3.54; p = 0.06) or multivariable analysis (HR: 1.36; 95% CI: 0.57-3.14; p = 0.50). High BMI did not increase the risk for initiation of dialysis in univariate (HR: 0.96; 95% CI: 0.58-1.60; p = 0.9) or multivariable analysis (HR: 1.77; 95% CI: 0.82-3.81; p = 0.14). Adding the interaction term (between BMI and glomerular filtration rate) to other variables, the risk of dialysis initiation significantly increased (HR: 3.06; 95% CI: 1.31-7.18; p = 0.01) in high-BMI patients. High BMI was not a predictor of CAC extent or progression. Conclusions: High BMI was not a predictor of CVEs. High BMI increased the risk for dialysis initiation, but high BMI was not associated to CAC extent and progression. The presence of confounders may underestimate the impact of high BMI on dialysis initiation.

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Section: Discussionsupporting

confidence: 64%

Impact of BMI on Cardiovascular Events, Renal Function, and Coronary Artery Calcification

Russo

Morrone²,

Errichiello³

et al. 2014

Blood Purif

View full text Add to dashboard Cite

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“…The other potential pathway between obesity and kidney injure is chronic inflammation [14,32,34]. In central obesity state, excessive pro-inflammatory adipokins are produced, anti-inflammatory adipokins (such as adiponetin) are reduced, and macrophage infiltration in adipose tissues is enhanced [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…These adiopocytokines play a role in energy homeostasis, insulin sensitivity, and vascular disease [13,14,32,33,34]. Among these adipocytokines, leptin and adiponectin could have beneficial effects.…”

Section: Discussionmentioning

confidence: 99%

Central Obesity, C-Reactive Protein and Chronic Kidney Disease: A Community-Based Cross-Sectional Study in Southern China

Chen

Liu

et al. 2013

Kidney Blood Press Res

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Objective: Previous studies have shown that central obesity is associated with chronic kidney disease (CKD). We hypothesized that the association of central obesity with CKD is modified by the presence of inflammation. To test this hypothesis, we performed this study. Methods: This was a cross-sectional study in southern China. Waist-to-height ratio (WHtR) was used as a central obesity index and C-reactive protein (CRP) was used as an index for inflammation. CKD was defined as estimated glomerular filtration rate(eGFR) <60 ml/min/1.73m² or albuminuria-to-creatinine ratio (ACR) >30mg/g. Multivariable logistic regressions were used and logistic regression models were adjusted for potential confounders and other components of metabolic syndrome. Results: 1834 subjects were included in the current study. WHtR, body mass index and waist circumference were significantly associated with the level of CRP. When adjustment for potential confounders, only central obesity with a higher CRP level was associated with CKD (Relavitve-risk Ratio, 95% CI: 1.68, 1.03 - 2.75, P = 0.04). In multivariate logistic models, WHtR was associated with CKD. The odd ratio for WHtR (every SD increment), was 1.38 (95% CI 1.15, 1.66, P < 0.001). Further adjustment for log-transformed CRP had an impact on the odd ratios. Conclusion: Central obesity is associated with CKD, independently of other MetS components. Central obesity is also associated with inflammation and the presence of inflammation modifies the associations of central obesity and CKD. This study is based on a community-based chinese population, and the results may only be applicable for Chinese population.

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“…Articles aging and obesity-related renal pathology diseases (10,19). Although the cellular basis of chronic inflammation during aging has not been determined, age-related abnormalities in T cells and macrophages may contribute to the increased levels of serum inflammatory markers during aging (20).…”

Section: Early Nutrition and Renal Injury During Agingmentioning

confidence: 99%

Postnatal early overnutrition causes long-term renal decline in aging male rats

et al. 2013

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Background:We evaluated the influence of postnatal early overnutrition on renal pathophysiological changes in aging rats. Methods: Three or 10 male pups per mother were assigned to either the small litter (SL) or normal litter (control) groups, respectively, during the first 21 d of life. The effects of early postnatal overnutrition were determined at 12 mo. results: SL rats weighed more than controls between 4 d and 6 mo of age (P < 0.05). However, between 6 and 12 mo, body weights in both groups were not different. In the SL group, at 12 mo, systolic blood pressure was higher and creatinine clearance was lower than the same in controls (P < 0.05). Numbers of CD68 (ED1)-positive macrophages and apoptotic cells in renal cortex were higher in SL rats (P < 0.05). Furthermore, index scores for glomerulosclerosis and tubulointerstitial fibrosis were higher in the SL group (P < 0.05). Significantly less glomeruli per section area were found in aging SL rats (P < 0.05). Immunoblotting and immunohistochemistry showed decreased intrarenal renin expression in SL rats (P < 0.05). conclusion: Early postnatal overnutrition can potentiate structural and functional abnormalities in the aging kidney and can lead to systolic hypertension with reduced intrarenal renin activity.

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Obesity, inflammation, and kidney disease

Cited by 40 publications

References 28 publications

Impact of BMI on Cardiovascular Events, Renal Function, and Coronary Artery Calcification

Impact of BMI on Cardiovascular Events, Renal Function, and Coronary Artery Calcification

Central Obesity, C-Reactive Protein and Chronic Kidney Disease: A Community-Based Cross-Sectional Study in Southern China

Postnatal early overnutrition causes long-term renal decline in aging male rats

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