Obesity is a risk factor for early pregnancy loss after IVF or ICSI

Fedorcsák, Péter; Storeng, Ritsa; Dale, Per Olav; Tanbo, Tom; Åbyholm, Thomas

doi:10.1080/j.1600-0412.2000.079001043.x

Cited by 183 publications

(70 citation statements)

References 24 publications

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“…Only 63% of cycles with a positive pregnancy test resulted in a live birth, and the overall early pregnancy loss rate was high (32%). The biochemical pregnancy loss rate of 16% is higher than that in routine assisted reproduction technique (11-13%) 32,33 and in our own assisted reproduction technique programme (13%). The clinical pregnancy loss rate of 13% is similar to the corresponding risk in the general population (10-15%) but less than those undergoing assisted reproduction technique (21.7 and 17.1% for singletons and twins, respectively).…”

Section: Discussioncontrasting

confidence: 50%

Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcome

Grace

El‐Toukhy

Scriven

et al. 2006

BJOG

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Objective To report on our experience with preimplantation genetic diagnosis (PGD) cycles performed for serious genetic disease in relation to the clinical factors affecting outcome.Design Retrospective review of data from a single centre.Setting Tertiary referral PGD centre in a London teaching hospital.Methods The PGD cycles included 172 cycles for chromosome rearrangements, 96 cycles for single-gene disorders and 62 cycles for X-linked disorders. In vitro fertilisation was the preferred method in chromosome rearrangement and X-linked cases, while intra cytoplasmic sperm injection was used in all single-gene disorders. Appropriate in situ hybridisation fluorescence probes were used in chromosome rearrangement and X-linked cases and polymerase chain reaction was used in single-gene disorders. All pregnancies were followed till delivery.Main outcome measure Live birth rate per PGD cycle started.Results Eighty-six percent of cycles started (283) reached oocyte retrieval and 3743 eggs were collected, of which 2086 fertilised normally (55.7%). Two hundred and fifty cycles (76%) had embryos sutiable for biopsy on day 3 of in vitro culture, 1714 embryos were biopsied, and in 205 cycles (62%), there was at least one unaffected embryo available for transfer, resulting in 90 pregnancies, 68 clinical pregnancies and 58 live birth. The live birth rate was 18% per cycle started, 21% per egg retrieval and 28% per embryo transfer which significantly affected the live birth outcome. Woman age, number of eggs collected and achieving cryopreservation of surplus embryos had no statistically significant effect on treatment outcome. ConclusionsThe live birth outcome of PGD cycles for serious genetic disorder is modest and is affected by the number of embryos genetically suitable for transfer.

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Section: Discussioncontrasting

confidence: 50%

Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcome

Grace

El‐Toukhy

Scriven

et al. 2006

BJOG

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“…A recent study from Finland reported that among a large group of women with oligomenorrhea and hirsutism, the most overweight women had the most profound changes in hormonal profile, that is high testosterone, high FTI and low SHBG (5). Obesity also seems to be an independent risk factor for early pregnancy loss in PCOS women (21).…”

Section: Discussionmentioning

confidence: 98%

Clinical, biochemical and ultrasonographic characteristics of Scandinavian women with PCOS

Kjøtrød¹,

Salvesen²,

Romundstad³

et al. 2004

Acta Obstet Gynecol Scand

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Background. The aim was to investigate the clinical, biochemical and ultrasonographic characteristics of Scandinavian women with polycystic ovarian syndrome (PCOS), and to see whether there were any differences between eumenorrhoic and oligoamenorrhoic women. Methods. Eighty women aged between 18 and 40 years with PCOS were investigated in a prospective study. The inclusion criteria were polycystic ovaries (PCO), body mass index (BMI) >25 kg/m 2 and at least one of the following: testosterone >2.5 nmol/L, sex hormone binding globulin (SHBG) <30 nmol/L, fasting C-peptide >1.0 nmol/L, oligoamenorrhea or hirsutism. Results. Eumenorrhoic and oligoamenorrhoic women with PCOS did not differ in age, age at menarche, blood pressure, BMI, free testosterone index (FTI), insulin C-peptide or fasting glucose. A thicker endometrium and a smaller ovarian volume were found in eumenorrhoic compared to oligoamenorrhoic patients. There was linear association between BMI and the number of diagnostic criteria met. Conclusion. BMI was associated with the severity of the PCOS. There were no differences in basic clinical and biochemical parameters between eumenorrhoic and oligoamenorrhoic patients with PCOS.Abbreviations: PCO: polycystic ovary; PCOS: polycystic ovarian syndrome; SHBG: sex hormone binding globulin; FTI: free testosterone index; BMI: body mass index.

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“…28,29 Hyperinsulinemia has been implicated as an independent risk factor for early pregnancy loss. 30 Glueck et al found a very low rate of first-trimester spontaneous abortion in patients receiving metformin during pregnancy. 31 We found no difference in abortion rate.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment and co‐administration of oral anti‐diabetic agent with clomiphene citrate or rFSH for ovulation induction in clomiphene‐citrate‐resistant polycystic ovary syndrome

Begum¹,

Akhter

Ehsan³

et al. 2013

J of Obstet and Gynaecol

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Obesity is a risk factor for early pregnancy loss after IVF or ICSI

Abstract: Obesity is an independent risk factor for early pregnancy loss. This risk is, in part, related to the lower number of collected oocytes in obese women.

Cited by 183 publications

References 24 publications

Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcome

Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcome

Clinical, biochemical and ultrasonographic characteristics of Scandinavian women with PCOS

Pretreatment and co‐administration of oral anti‐diabetic agent with clomiphene citrate or rFSH for ovulation induction in clomiphene‐citrate‐resistant polycystic ovary syndrome

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