2021
DOI: 10.1017/s0950268821001023
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Obesity is a strong risk factor for short-term mortality and adverse outcomes in Mexican patients with COVID-19: a national observational study

Abstract: Conflicting results have been obtained through meta-analyses for the role of obesity as a risk factor for adverse outcomes in patients with coronavirus disease-2019 (COVID-19), possibly due to the inclusion of predominantly multimorbid patients with severe COVID-19. Here, we aimed to study obesity alone or in combination with other comorbidities as a risk factor for short-term all-cause mortality and other adverse outcomes in Mexican patients evaluated for suspected COVID-19 in ambulatory units and hospitals i… Show more

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Cited by 37 publications
(32 citation statements)
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“…Although the association between obesity and COVID-19 severity has been evaluated in other high-quality studies, 4 , 14 , 15 , 16 our retrospective study covers the entire country of Brazil during the pre-vaccination period. By using a government database created exclusively for monitoring SARS, we leveraged the following: (1) a large sample size of hospitalized patients with laboratory-confirmed COVID-19; (2) information on comorbidities and BMI collected at the time of hospital admission, therefore simultaneously with the laboratory diagnosis of COVID-19; (3) the specific contribution of obesity, CVD, and diabetes to the risk of severe COVID-19, (4) stratification by BMI and age, and (5) analysis of ICU admission, ventilatory support, and death.…”
Section: Discussionmentioning
confidence: 99%
“…Although the association between obesity and COVID-19 severity has been evaluated in other high-quality studies, 4 , 14 , 15 , 16 our retrospective study covers the entire country of Brazil during the pre-vaccination period. By using a government database created exclusively for monitoring SARS, we leveraged the following: (1) a large sample size of hospitalized patients with laboratory-confirmed COVID-19; (2) information on comorbidities and BMI collected at the time of hospital admission, therefore simultaneously with the laboratory diagnosis of COVID-19; (3) the specific contribution of obesity, CVD, and diabetes to the risk of severe COVID-19, (4) stratification by BMI and age, and (5) analysis of ICU admission, ventilatory support, and death.…”
Section: Discussionmentioning
confidence: 99%
“…There are currently no sufficiently proven interventions for COVID-19 that may decrease mortality and complication rates at every stage of disease. Comorbidities like obesity, hypertension and diabetes mellitus worsen the prognosis of the disease [ 38 , 39 , 40 , 41 ]. Furthermore, disruptions in the gut microbiome have been hypothesized to be associated with disease progression in COVID-19 [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Also, our study is limited by the fact that we could not assess disease progression according to clinical criteria since parameters for staging patients are not captured in this dataset, and thus we used severity of symptoms (respiratory symptoms) as a correlate of disease severity at admission since respiratory symptoms are strongly associated with the risk of death and other adverse outcomes. The exclusion of patients with a negative RT-PCR for SARS-CoV-2 could have introduced bias in our study since a negative RT-PCR result does not necessarily imply the absence of the disease and we did not compare characteristics of patients with negative, positive and pending testing results, which have been shown to have different baseline and follow-up characteristics, as well as different associations with mortality risk in a previous study performed in Mexican ambulatory and hospitalised patients [ 21 ]. Furthermore, patients <20 and ≥80 years were likely underrepresented in our study due to lower testing rates in these age categories, which compromise validity of our findings.…”
Section: Discussionmentioning
confidence: 99%