Obesity Is an Independent Determinant of Ischemia-Modified Albumin

Abstract

Objective: We have measured ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS) and high-sensitivity C-reactive protein (hsCRP) levels in obese and normal-weight subjects to investigate if IMA can be used as a biomarker of oxidative stress and inflammation and if IMA was an independent determinant of obesity or not. Methods: The study was performed on 92 obese subjects (20 male, 72 female) aged 38 ± 11 years and 78 normal-weight controls (19 male, 59 female) aged 37 ± 11 years. Serum lipids, IMA, TAS, TOS, and hsCRP levels of the subjects were measured. Results: IMA (p < 0.05), TOS (p < 0.001), and hsCRP (p < 0.001) levels of the obese subjects were significantly higher, whereas TAS levels were significantly lower (p < 0.05) than those of the controls after adjustment for age and gender. In the linear regression analysis, waist circumference (r² = 0.139, p < 0.01), BMI (r² = 0.136, p < 0.01) and insulin (r² = 0.120, p < 0.05) were shown to be significant independent determinants of IMA levels. Conclusions: We have found that oxidative stress and inflammation were increased and antioxidative defense was decreased, which resulted in increased levels of IMA, a biomarker of ischemia, in obese subjects. Also, obesity and insulin were found to be independent determinants of IMA. Thus, obese subjects are under high risk of ischemia, and IMA may be used as a biomarker of oxidative stress and ischemia. Further larger investigations are needed to confirm this opinion.

Advanced oxidation protein products and ischaemia‐modified albumin in obstructive sleep apnea

“…Ischaemia‐modified albumin (IMA) is a relatively new biomarker which is under research in several ischaemic and/or hypoxic conditions . In a recent study performed in the obese subjects compared to the normal‐weight controls, IMA and TOS were found to be elevated, whereas TAC significantly decreased and BMI was reported to be as an independent determinant for IMA .…”

The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

“…In recent years, elevated levels of IMA are thought to be associated with several diseases based on oxidative stress [5–7]. The cardiovascular risk factors and IMA are reported to increase in obesity [8, 9], metabolic syndrome [10], type 2 diabetes mellitus (DM) [11], and hypercholesterolemia [12]. …”

Role of ischemia-modified albumin in clinical practice

“…In another report, it was revealed that patients with hypertension had elevated IMA levels [50]. Also, it was reported that obesity caused increase in IMA levels indicating risk of ischemia in obese people [51]. In a study, higher levels of IMA were determined in patients who experience seizure, and it was reported that it could be used for differentiation of seizures [52].…”