Obesity is associated with increased asthma severity and exacerbations, and increased serum immunoglobulin <scp>E</scp> in inner‐city adults

Fitzpatrick, Stephanie L.; Joks, Rauno; Silverberg, Jonathan I.

doi:10.1111/j.1365-2222.2011.03863.x

Cited by 70 publications

(57 citation statements)

References 66 publications

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“…21 Epidemiologic studies have consistently found a strong link between asthma and obesity. [21][22][23][24] However, previous studies found conflicting results about whether AD is associated with overweight or obesity. This has important clinical ramifications, because obesity may be a modifiable risk factor for and/or comorbidity of AD.…”

mentioning

confidence: 97%

Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis

Zhang

Silverberg

2015

Journal of the American Academy of Dermatology

247

213

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mentioning

confidence: 97%

Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis

Zhang

Silverberg

2015

Journal of the American Academy of Dermatology

247

213

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“…Most studies on the association between BMI and allergic disorders in children are in high-income countries [24][25][26] while little is known on this association in children from low-to-middle income countries. Among high-SES school children in this study, we also found that skin reactivity to cockroach and BMI were positively associated with the increased risk of eczema.…”

Section: Discussionmentioning

confidence: 99%

Allergic disorders and socio‐economic status: a study of schoolchildren in an urban area of Makassar, Indonesia

Hamid

Wahyuni

Leeuwen

et al. 2015

Clin Experimental Allergy

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SummaryBackground In urban centres of developing countries, there is great variation in socioeconomic status (SES) and lifestyle; however, little information is available on allergic disorders in groups with high-or low-SES within the same urban area. Objective To determine the prevalence of allergic disorders and investigate risk factors related to them among high-and low-SES schoolchildren in Makassar, the capital city of South Sulawesi, Indonesia. Method This cross-sectional study was performed in 623 children originating from high-(N = 349) and low-SES (N = 274) schools. Information on reported allergic symptoms and potential factors associated with allergic disorders was obtained by questionnaire. Specific IgE and skin prick test (SPT) reactivity were determined against aeroallergens [Dermatophagoides pteronyssinus (HDM) and cockroach]. Total IgE and helminth infections were also assessed. Result The prevalence of SPT to any aeroallergens was significantly higher in high-SES than in low-SES school (25% vs. 8%, P < 0.001, respectively). However, specific IgE against cockroach and total IgE were significantly lower in high-than in low-SES children. Allergic symptoms were reported more often in low-compared to high-SES children. Specific IgE to aeroallergens significantly increased the risk of SPT positivity to the same aeroallergen in the high-, but not in the low-SES children. In the high-but not in low-SES, there was a significant positive association between SPT to HDM and wheeze. Similarly, cockroach skin reactivity and elevated BMI increased the risk of eczema in the high-SES children only. Conclusion and Clinical Relevance Skin prick test is higher in high-SES, whereas IgE and allergic symptoms are higher in low-SES children. Specific IgE is a risk factor for being SPT-positive, and SPT positivity is a risk factor for allergic symptoms but only in children of high-and not low-SES school. Therefore, the socio-economic status of a child might affect the diagnosis of allergic disease in a developing country.

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“…Extrapulmonary factors including tobacco smoking [30], psychological dysfunction [31], rhinosinusitis/nasal polyps [32], obesity [33] and gastro-oesophageal reflux disease [34] have been associated with recurrent severe exacerbations, and current management guidelines advocate identification and management of these conditions [2]. In identifying determinants of not attaining 'well controlled asthma' in the Gaining Optimal Asthma controL (GOAL) study, the greatest odds ratio was current smoking when compared with never smokers (odds ratio 2.8) [35].…”

Section: Risk Factors For Exacerbationsmentioning

confidence: 99%

Asthma control and exacerbations

Brisk

Heaney

2016

Current Opinion in Pulmonary Medicine

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Some patients with asthma have persistent symptoms in the absence of type-2 cytokine driven-eosinophilic airways inflammation due to noncorticosteroid responsive mechanisms (T2-low disease). Composite biomarker strategies using easily measured surrogate indicators of type-2 inflammation (such as fractional exhaled nitric oxide, blood eosinophil count and serum periostin levels) may predict exacerbation risk better but it is unclear if they can be used to adjust corticosteroid treatment. Biomarkers will be used to target novel biologic treatments but additionally may be used to optimize corticosteroid treatment dose and act as prognostics for exacerbation risk and potentially other important longer term asthma outcomes.

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Obesity is associated with increased asthma severity and exacerbations, and increased serum immunoglobulin E in inner‐city adults

Abstract: Obesity in inner-city adults may be both a risk and exacerbating factor for atopic asthma.

Cited by 70 publications

References 66 publications

Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis

Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis

Allergic disorders and socio‐economic status: a study of schoolchildren in an urban area of Makassar, Indonesia

Asthma control and exacerbations

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