Obesity lowers the threshold of allergic sensitization and augments airway eosinophilia in a mouse model of asthma

Dietze, Jared L.; Böcking, Christian; Heverhagen, Johannes T.; Voelker, M. N.; Renz, Harald

doi:10.1111/all.12031

Cited by 40 publications

(44 citation statements)

References 85 publications

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“…In mouse models of allergic airway inflammation, body weight has been correlated with airway eosinophilia, suggesting that obesity may lower the threshold for allergic sensitization and ORIGINAL ARTICLE augment airway eosinophilia (28,29). In contrast, other studies have found no association between body weight and eosinophilia in murine models of asthma (30).…”

Section: Discussionmentioning

confidence: 99%

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Han

Forno

Celedón

2014

Am J Respir Crit Care Med

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Rationale: Whether allergic airway inflammation mediates the association between overweight or obesity and childhood asthma is unknown.Objectives: To examine adiposity, asthma, and fractional exhaled nitric oxide (FE NO ) in U.S. children.Methods: Cross-sectional study of indicators of adiposity or obesity, FE NO (a biomarker of eosinophilic airway inflammation), and asthma in 2,681 children aged 6-17 years in the 2007-2010 National Health and Nutrition Examination Survey. Adiposity measures included body mass index (BMI), percent body fat (PBF), and waist circumference (WC).Measurements and Main Results: BMI, PBF, and WC were associated with asthma among children with low FE NO (odds ratio, 1.54-1.68; P , 0.01), but not among children with increased FE NO . Among children without asthma, BMI, PBF, and WC were associated with higher FEV 1 and FVC, and lower FEV 1 /FVC. Among children with asthma and a high FE NO , all adiposity indicators were associated with decreased FEV 1 /FVC (b = 21.5% to 21.7% per z score) but not with FEV 1 or FVC. Higher BMI or PBF was associated with worse asthma severity or control in children with asthma and increased FE NO , but not in children with asthma and low FE NO . Similar results were obtained in a secondary multivariate analysis of overweight or obesity (defined as BMI >85th percentile) and asthma or indicators of asthma severity or control, stratified by FE NO level.Conclusions: Adiposity indicators are associated with asthma in children with low FE NO . Among children with asthma, adiposity indicators are associated with worse asthma severity or control in those with high FE NO .

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Section: Discussionmentioning

confidence: 99%

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Han

Forno

Celedón

2014

Am J Respir Crit Care Med

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“…However, sensitization to food allergens may have been present in the first year of life, which we did not assess. In mice, obesity lowered the threshold for atopic sensitization, suggesting that obesity causes atopy [23]. …”

Section: Discussionmentioning

confidence: 99%

Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood

Byberg

Eide

Forman

et al. 2016

Clin Transl Allergy

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BackgroundThe results of studies on the associations of childhood excessive weight/obesity and physical activity with atopic sensitization and atopic diseases are inconsistent. We studied the associations of anthropometry and physical activity in childhood with atopic sensitization and atopic diseases in late childhood.MethodsIn a cohort study including cases exposed to preeclampsia during pregnancy and controls, anthropometry and physical activity were assessed at several ages in 617 children. Associations with atopic sensitization and atopic diseases in late childhood were analysed using multiple logistic regression.ResultsBody mass index standard deviation score (BMI SDS) at 1 year and low physical activity at 3–6 years were positively associated with atopic sensitization at 12.8 years [adjusted odds ratio (OR) 1.22; 95 % confidence interval (1.00, 1.49) and OR 2.36; (1.15, 4.81), respectively]. Change in BMI SDS from 1 to 4 years, BMI SDS at 4 years, and high physical activity at 6–10 years were positively associated with atopic dermatitis by 10.8 years [OR 1.46; (1.11, 1.92); OR 1.32; (1.06, 1.65) and OR 1.94; (1.16, 3.24); respectively]. Low physical activity at 3–6 and 6–10 years were positively associated with asthma by 10.8 years [OR 3.61; (1.56, 8.36) and OR 2.52; (1.24, 5.12), respectively].ConclusionsBMI and physical activity in early childhood were associated with atopic sensitization, atopic dermatitis and asthma in later childhood. Larger cohorts with repeated measurements of both predictors and outcomes are required to further elucidate this issue.Trial registration Our study was observational without any clinical intervention on the participants. Therefore, no trial registration number is availableElectronic supplementary materialThe online version of this article (doi:10.1186/s13601-016-0124-9) contains supplementary material, which is available to authorized users.

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“…Obesity in mouse models of asthma has been shown to lower the threshold for allergic sensitization, measured by IgE, interleukin (IL)-5, and eosinophilia (47) . Cluster analysis in adults has shown that certain “obese asthmatic” phenotypes have increased IgE (10) .…”

Section: Discussionmentioning

confidence: 99%

Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children

Forno

Acosta‐Pérez

Brehm

et al. 2014

Journal of Allergy and Clinical Immunology

116

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Background: Whether adiposity indicators other than body mass index should be used in studies of childhood asthma is largely unknown. The role of atopy in “obese asthma” is also unclear. Objective: To examine the relation among adiposity indicators, asthma, and atopy in Puerto Rican children, and to assess whether atopy mediates the obesity-asthma association. Methods: In a study of Puerto Rican children with (n=351) and without (n=327) asthma, we measured body mass index (BMI), percent body fat (PBF), waist circumference (WC), and waist-to-hip ratio (WHR). The outcomes studied included asthma, lung function, measures of atopy, and, among cases, indicators of asthma severity or control. We performed mediation analysis to assess the contribution of atopy to the relationship between adiposity and asthma. Results: BMI, PBF, and WC were associated with increased odds of asthma. Among cases, all three measures were generally associated with lung function, asthma severity/control, and atopy; however, there were differences depending on the adiposity indicator analyzed. Atopy considerably mediated the adiposity-asthma association in this population: allergic rhinitis accounted for 22-53% of the association with asthma, and sensitization to cockroach mediated 13-20% of the association with FVC and 29-42% of the association with emergency room visits for asthma. Conclusions: Adiposity indicators are associated with asthma, asthma severity/control, and atopy in Puerto Rican children. Atopy significantly mediates the effect of adiposity on asthma outcomes. Longitudinal studies are needed to further investigate the causal role, if any, of adiposity distribution and atopy on “obese asthma” in childhood. Clinical Implications: Assessment of adiposity rather than sole reliance on BMI may be important in studies of childhood asthma. Atopy is an important mediator of the relation between obesity and asthma in Puerto Rican children. Capsule Summary: In a cohort of Puerto Rican children, measures of adiposity were associated with asthma, asthma severity/control, and atopy; however, some differences existed depending on the adiposity indicator utilized. Atopy significantly mediated the association between adiposity indicators and asthma.

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Obesity lowers the threshold of allergic sensitization and augments airway eosinophilia in a mouse model of asthma

Abstract: This obesity model demonstrates that HFD-induced obesity lowers the sensitization threshold in a model of asthma. This finding helps to understand why, particularly during childhood, obesity is a risk factor for the development of allergic asthma.

Cited by 40 publications

References 85 publications

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood

Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children

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