Obesity Measurement Index Is Associated With Hemoglobin A1c Level in Young Adult Without Diabetes: A Single-Center Cross-Sectional Study

Sarnings, Waode; Aman, Andi Makbul; Rasyid, Haerani; Bakri, Syakib; Sanusi, Himawan; Daud, Nu’man As; Zainuddin, Andi Alfian

doi:10.14740/jem823

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Obesity can affect the level of HbA1c. There was a significant correlation between anthropometric measurements and HbA1c, with HbA1c levels being higher in the obese group, and significant patient scores with HbA1c and high body fat indicate the relationship of the molecule with obesity 13 . Our data also support these findings.…”

Section: Discussionmentioning

confidence: 88%

Evaluation of mucin-1, nuclear factor κB, and hemoglobin A1c levels in obese and non-obese individuals

Fadıloğlu,

Bozkurt,

Akarsu

et al. 2024

Rev. Assoc. Med. Bras.

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OBJECTIVE: Obesity is a chronic multisystem disease associated with increased morbidity and mortality. Obesity, which is a complex, multifactorial, and heterogeneous condition, is thought to result from the interaction of environmental, physiological, and genetic factors. In this study, the relationship between serum levels of hemoglobin A1c, mucin-1, and nuclear factor κB in obese and healthy cohorts was evaluated along with biochemical and gene expressions and with demographic and clinical covariates, and their effects on obesity were evaluated. METHODS: This case-control study included a total of 80 individuals, 40 healthy controls and 40 obesity patients, consisting of female and male aged between 18 and 63 years. Hemoglobin A1c, mucin-1, and nuclear factor κB levels were determined by ELISA in serum samples obtained from patients. In addition, aspartate aminotransferase, alanine transaminase, low density lipoprotein, and glucose values were measured. The gene expressions of the same markers were analyzed by quantitative real-time polymerase chain reaction, and their regulation status was defined. RESULTS: Serum levels of hemoglobin A1c, mucin-1, and nuclear factor κB were found to be high in obese individuals (p<0.05). The gene expression of these serum markers was found to be upregulated. Of the anthropometric measurements, waist circumference and body mass index were correlated with both serum markers and gene expressions (p<0.05). CONCLUSION: In addition to the known association of hemoglobin A1c and nuclear factor κB with obesity, serum levels of mucin-1 as well as upregulation of genes point to its modifier effect on obesity. These parameters can be the powerful markers in the diagnosis of obesity.

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Section: Discussionmentioning

confidence: 88%

Evaluation of mucin-1, nuclear factor κB, and hemoglobin A1c levels in obese and non-obese individuals

Fadıloğlu,

Bozkurt,

Akarsu

et al. 2024

Rev. Assoc. Med. Bras.

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“…Regarding ALB-g, the primary observations indicated a negative correlation with fat (DXA), both in grams (for the entire sample and DM2 group) and as a percentage in DM2 postmenopausal women. The inverse relationship between ALB-g and fat mass has been established in previous studies [ 37 , 38 ], and it has been recognized as a reliable measure for monitoring glycemic control in individuals with diabetes over a moderate period of time [ 39 ]. In the present study, we observed that postmenopausal women with diabetes exhibited elevated levels in circulation, as shown in Figure S1 Supplementary (only included for the discussion section).…”

Section: Discussionmentioning

confidence: 99%

Differential Association of Glycation Products with Bone Mineral Density and Fat Mass in Healthy and Diabetes Type 2 Subjects from Mexican Southeastern: A Cross Sectional Study

Ferreyro-Bravo,

Ceballos-Cruz,

Urruchua-Rodríguez

et al. 2023

Medicina

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Background: Glycation products have been linked to decreased bone mineral density (BMD) in a number of clinical settings. This study examined the correlation between early glycation products (HbA1c and glycated albumin (ALB-g)) and advanced glycation end products (pentosidine (PTD)) with BMD in two groups of participants: those with type 2 diabetes mellitus (DM2) and those without diabetes or any other comorbidities (noDM). All of the participants had resided in southeastern Mexico for a minimum of 10 years. Material and Methods: This study included 204 participants: 112 (55%) with DM2 and 92 (45%) healthy subjects. We utilized dual X-ray absorptiometry (DXA) to measure both the total and segment-specific BMD and adipose mass. In addition, the fasting blood glucose, HbA1c, PTD, and ALB-g parameters were measured. Correlation and logistic regression analyses were conducted. Results: There was an inverse correlation between PTD and BMD in all anatomical regions among postmenopausal women (PMW) in the DM2 group, whereas in non-PMW, only the waist-to-height ratio was statistically significant. A negative correlation was observed between HbA1c levels and BMD in the arms and legs of DM2 individuals. However, in the noDM group, a negative correlation was found between HbA1c levels and BMD in the pelvis, while a positive association was observed between HbA1c and indicators of adipose tissue. ALB-g, demonstrated a negative correlation with fat mass. After performing binary logistic regressions, the following odds ratios (OR) for osteopenia/osteoporosis risk were determined: PTD OR 1.1 (p = 0.047) for DM2 PMW, HbA1c OR 1.4 (p = 0.048), and fat mass content OR 1.011 (p = 0.023) for the entire sample. Conclusions: Glycation products are associated with BMD differentially depending on the analyzed anatomical segment, but PTD, HbA1c, and fat mass are significant predictors of low bone mass. In prospective studies, this association could be determined using other techniques involving three-dimensional analysis of bone architecture to evaluate bone architecture.

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“…Excess fat cells, over time, will cause fat cells to become resistant to insulin's antilipolytic actions, resulting in an increase in the process of lipolysis and free fatty acids in plasma. Free fatty acids boost gluconeogenesis resistance, which then triggers insulin in the liver and muscles (Sarnings et al, 2022). However, in patients with type 2 diabetes mellitus, higher BMI and WC were linked to increased insulin resistance and lower insulin sensitivity (Deusdará et al, 2022;Zhao et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Thyroid Function Markers in Type 2 Diabetic Patients in Relation to Insulin Resistance

Othman,

Kakey

2023

SJUOZ

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Diabetes mellitus (DM) and thyroid disorders are both caused by endocrine abnormalities, and both have been shown to have a reciprocal influence and frequently coexist. Hence, the current study aims to detect the thyroid functions markers among patients with Type 2 diabetes (T2DM). In this research study, 90 enrolled participants aged 40 to 60 years were taken as samples for the study. There were 66 with T2DM and 24 who were non diabetic healthy individual. All individuals were investigated in terms of age, gender, diabetes duration, glycemic control (HbA1c), fasting blood glucose (FBG), diabetic complications, Body mass index (BMI), waist circumference (WC), and family history of DM. Samples were to assess serum thyroid hormones (TSH, FT3 and FT4), HbA1c, FBG, and insulin levels. The study's findings showed higher glucose incidence, hyperinsulinemia and higher insulin resistance (IR) in diabetic patients. Additionally, it has been noted that T2DM patients have low TSH concentrations and elevated blood concentrations of FT4 and FT3 than controls. Moreover, there was a highly significant correlation between serum FT4 and FT3 with values of FBG, insulin and IR. Also, a significant association between WC with insulin and Homa – Ir was noted. In conclusion, the diabetic patients showed significant relations with thyroid functions status.

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Obesity Measurement Index Is Associated With Hemoglobin A1c Level in Young Adult Without Diabetes: A Single-Center Cross-Sectional Study

Cited by 3 publications

References 17 publications

Evaluation of mucin-1, nuclear factor κB, and hemoglobin A1c levels in obese and non-obese individuals

Evaluation of mucin-1, nuclear factor κB, and hemoglobin A1c levels in obese and non-obese individuals

Differential Association of Glycation Products with Bone Mineral Density and Fat Mass in Healthy and Diabetes Type 2 Subjects from Mexican Southeastern: A Cross Sectional Study

Evaluation of Thyroid Function Markers in Type 2 Diabetic Patients in Relation to Insulin Resistance

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