Obesity, metabolic complications and the menopause: an opportunity for prevention

Teede, Helena; Lombard, Catherine B; Deeks, Amanda

doi:10.3109/13697130903296909

Cited by 65 publications

(36 citation statements)

References 44 publications

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“…In the current study, to investigate hormonal effects, a large population of women was divided by menopausal profile, which was considered to be a critical contributing factor in determining hormonal differences in women. Our finding was consistent with previous studies [16,17,18], which reported an increased trend in the prevalence of obesity after menopause. It is possible that the findings are associated with changes in reproductive hormones, such as estrogen, follicle stimulating hormone (FSH), and luteinizing hormone (LH) as well as melatonin secretion after entering menopause [15,16].…”

Section: Discussionsupporting

confidence: 94%

The Risk of Being Obese According to Short Sleep Duration Is Modulated after Menopause in Korean Women

Doo

Kim

2017

Nutrients

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We previously reported that women with short sleep duration consumed more dietary carbohydrate and showed an increased risk for obesity compared to those who slept adequately, but not for men. Using a cross-sectional study of 17,841 Korean women, we investigated the influence of sleep duration on obesity-related variables and consumption of dietary carbohydrate-rich foods in relation to menopausal status. Premenopausal women with short sleep duration had significantly greater body weight (p = 0.007), body mass index (p = 0.003), systolic and diastolic blood pressures (p = 0.028 and p = 0.024, respectively), prevalence of obesity (p < 0.016), and consumption of more carbohydrate-rich foods such as staple foods (p = 0.026) and simple sugar-rich foods (p = 0.044) than those with adequate sleep duration after adjustment for covariates. Premenopausal women with short sleep duration were more obese by 1.171 times compared to subjects adequate sleep duration (95% confidence interval = 1.030–1.330). However, obesity-related variables, dietary consumption, and odds of being obese did not differ according to sleep duration for postmenopausal women. The findings suggest that the increased risk for obesity and consumption of dietary carbohydrate-rich foods with short sleep duration appeared to disappear after menopause in Korean women.

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Section: Discussionsupporting

confidence: 94%

The Risk of Being Obese According to Short Sleep Duration Is Modulated after Menopause in Korean Women

Doo

Kim

2017

Nutrients

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“…The incidence of metabolic alteration including the development of insulin resistance increases substantially during menopause [28]. In our study, female subjects in the menstrual stage had significantly lower mean ferritin levels than menopausal females.…”

Section: Discussionmentioning

confidence: 71%

Increased Ferritin Concentrations Correlate with Insulin Resistance in Female Type 2 Diabetic Patients

Yu¹,

Huang²,

Chang³

et al. 2012

Ann Nutr Metab

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Aims: Iron overload identified by elevated ferritin concentrations has been implicated in risks of altered glucose metabolism and diabetic complications. The relationship between ferritin and insulin resistance in different gender and ethnicities remains uncertain; this study aimed to investigate it using homeostasis model assessment (HOMA-IR), and to explore whether it is gender-specific. Methods: A total of 524 type 2 diabetic patients were selected cross-sectionally from a cohort participating in a diabetic control study in Taiwan. Result: Overall, tertiles of ferritin were significantly and dose-dependently associated with elevated fasting plasma glucose, hemoglobin A1c, high-sensitivity C-reactive protein, HOMA-IR levels as well as Western dietary pattern scores generated by factor analysis (all p trend <0.05). Stratified by gender, a 1-tertile ferritin increase significantly correlated with a 0.241-unit increase in HOMA-IR (beta = 0.241, p = 0.001) in female diabetes, but not in male diabetes (beta = 0.072, p = 0.232), after adjusting for demographic, dietary, clinical and inflammatory factors. Conclusion: Iron overload, which produces elevated levels of ferritin, may augment insulin resistance in female but not in male type 2 diabetes. Longitudinal studies are warranted to establish relationships between iron stores and diabetes development in men and women of different ethnicities.

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“…[1] MetS has emerged as an underlying risk factor for a wide variety of diseases[4,8,14] and most postmenopausal women exhibit three or more MetS components. [24] Several factors can contribute to the increased prevalence of MetS in postmenopausal women, including age, reduced physical activity and energy expenditure,[20,35] increased caloric intake,[23] variation in hormonal patterns,[33] and attitude and perception relative to weight and weight management after menopause. These risk factors for MetS are of considerable importance to middle-aged and older women’s health, due to the fact that MetS components increase through the transition period from pre- to post menopause which, in turn, might explain the increased incidence and prevalence of diseases and comorbidities in women after menopause.…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory Fitness and Metabolic Syndrome in Postmenopausal African-American Women

et al. 2016

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We examined the association of cardiorespiratory fitness with metabolic syndrome in overweight/obese postmenopausal African-American women. Pooled baseline data on 170 African- American women from two exercise trials were examined. Metabolic syndrome was defined as at least three of the following: abdominal obesity, glucose intolerance, hypertension, low high-density lipoprotein cholesterol (HDL-C), and high triglycerides. Cardiorespiratory fitness (VO2peak) was determined using the Bruce treadmill protocol and categorized as: Very Low (VLCRF < 18 mL·kg−1 ·min−1), Low (LCRF = 18.0 – 22.0 mL·kg−1 ·min−1), and Moderate (MCRF > 22.0 mL·kg−1 ·min−1). Associations of metabolic syndrome with cardiorespiratory fitness were analyzed using one-way ANOVA and linear regression. VO2peak was significantly lower in the VLCRF compared to the MCRF group. Lower cardiorespiratory fitness was associated with higher prevalence of metabolic syndrome, abdominal obesity, hypertriglyceridemia, and low HDL among overweight/obese postmenopausal African-American women. In fully adjusted models, higher waist circumference and triglycerides were associated with lower VO2peak levels (P < 0.01) and higher HDL-C was associated with higher VO2peak levels (P = 0.03). Overweight/obese postmenopausal African-American women with very low cardiorespiratory fitness are more likely to have metabolic syndrome, higher body mass index, and unhealthier levels of certain metabolic syndrome components than women with moderate cardiorespiratory fitness.

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Obesity, metabolic complications and the menopause: an opportunity for prevention

Cited by 65 publications

References 44 publications

The Risk of Being Obese According to Short Sleep Duration Is Modulated after Menopause in Korean Women

The Risk of Being Obese According to Short Sleep Duration Is Modulated after Menopause in Korean Women

Increased Ferritin Concentrations Correlate with Insulin Resistance in Female Type 2 Diabetic Patients

Cardiorespiratory Fitness and Metabolic Syndrome in Postmenopausal African-American Women

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