Obesity, Metabolic Syndrome, and Osteoarthritis—An Updated Review

Sampath, Samuel Joshua Pragasam; Venkatesan, Vijayalakshmi; Ghosh, Sudip; Kotikalapudi, Nagasuryaprasad

doi:10.1007/s13679-023-00520-5

Cited by 31 publications

(7 citation statements)

References 238 publications

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“…OA, obesity and diabetes are known to be associated with pro-inflammatory states 39 , 40 . There have been a number of interesting findings reported in the literature in which associations of various inflammatory markers or cytokines with symptoms in OA have differed by sex.…”

Section: Discussionmentioning

confidence: 99%

The impact of diabetes status on pain and physical function following total joint arthroplasty for hip and knee osteoarthritis: variation by sex and body mass index

Power,

Perruccio,

Canizares

et al. 2024

Sci Rep

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Few studies have examined diabetes impact on total joint arthroplasty (TJA) outcomes, with variable findings. We investigated the association between diabetes and post-TJA physical function and pain, examining whether diabetes impact differs by sex and BMI. Patient sample completed questionnaires within 3 months prior to hip or knee TJA for osteoarthritis (OA) and 1-year post-surgery. Surgical ‘non-response’ was defined as < 30% improvement in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and physical function at 1-year. Two adjusted logistic regression models were estimated: (1) excluding, (2) including an interaction between diabetes, sex and BMI. The sample (626 hip, 754 knee) was 54.9% female, had mean BMI of 30.1, 13.0% reported diabetes. In adjusted models excluding an interaction, diabetes was not associated with non-response. However, a significant 3-way interaction (physical function: p = 0.003; pain: p = 0.006) between diabetes, sex, and BMI was found and was associated with non-response: non-response probability increased with increasing BMI in men with diabetes, but decreased with increasing BMI in women in diabetes. Findings suggest uncertainty in diabetes impact may be due to differential impacts by sex and BMI. A simple consideration of diabetes as present vs. absent may not be sufficient, with implications for the large TJA population.

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Section: Discussionmentioning

confidence: 99%

The impact of diabetes status on pain and physical function following total joint arthroplasty for hip and knee osteoarthritis: variation by sex and body mass index

Power,

Perruccio,

Canizares

et al. 2024

Sci Rep

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show abstract

“…The causal relationship between weight gain and increased risk of OA can be revealed in several ways. Excess weight not only increases the load on the load-bearing joints but also leads to altered lines of force and decreased joint stability due to decreased muscle strength [ 38 , 39 ]. Also, in obese conditions, the pro-inflammatory state of adipose tissue macrophages (ATMs) in adipose tissue is transformed, leading to an increase in the production of pro-inflammatory cytokines, chemokines, and reactive oxygen species, which promotes the development of osteoarthritis [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Weight change patterns across adulthood are associated with the risk of osteoarthritis: a population-based study

Cui,

Zhang,

Deng

et al. 2024

Aging Clin Exp Res

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Background Body weight has been recognized as a driving factor of osteoarthritis. Few studies had investigated the association between weight status across adulthood and risk of osteoarthritis (OA). This study investigates the association of weight change patterns across adulthood (lasting at least 25 years) with the risk of OA from the National Health and Nutrition Examination Survey (NHANES) 2013–2018. Methods The study assessed the relationship between weight change across adulthood and OA in 7392 individuals aged > 50 spanning a minimum of 25 years. Multivariate linear regression analyses were utilized to detect the association between weight change patterns and self-reported OA. Restricted cubic splines (RCS) were used to examine the nonlinear relationship between absolute weight change and OA risk. Results From 10 years ago to survey, the risk of OA was 1.34-fold (95% CI 1.07–1.68) in people changed from obese to non-obese, 1.61-fold (95% CI 1.29–2.00) in people change from non-obese to obese, and 1.82-fold (95% CI 1.49–2.22) in stable obese people compared with people who were at stable normal weight. Similar patterns were also observed at age 25 years to baseline and age 25 years to 10 years before the baseline. The dose–response association of RCS found a U-shaped relationship between absolute weight change and OA risk. Conclusions The study suggests that weight patterns across adulthood are associated with the risk of OA. These findings stressed important to maintain a normal weight throughout adulthood, especially to prevent ignored weight gain in early adulthood to reduce OA risk later.

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“…This study has certain limitations. (1) The number of included samples for RNA sequencing in OA cartilage is limited. (2) The underlying mechanisms by which PSD95 promotes OA were not extensively explored.…”

Section: Discussionmentioning

confidence: 99%

“…Knee osteoarthritis (OA) is a widespread joint disorder, especially among older adults over 60 [1,2]. No practical methods are available to reverse cartilage degeneration [3].…”

Section: Introductionmentioning

confidence: 99%

PSD95 as a New Potential Therapeutic Target of Osteoarthritis: A Study of the Identification of Hub Genes through Self-Contrast Model

Huang,

Lin,

Shen

et al. 2023

IJMS

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Osteoarthritis (OA) is a worldwide joint disease. However, the precise mechanism causing OA remains unclear. Our primary aim was to identify vital biomarkers associated with the mechano-inflammatory aspect of OA, providing potential diagnostic and therapeutic targets for OA. Thirty OA patients who underwent total knee arthroplasty were recruited, and cartilage samples were obtained from both the lateral tibial plateau (LTP) and medial tibial plateau (MTP). GO and KEGG enrichment analyses were performed, and the protein–protein interaction (PPI) assessment was conducted for hub genes. The effect of PSD95 inhibition on cartilage degeneration was also conducted and analyzed. A total of 1247 upregulated and 244 downregulated DEGs were identified. Significant differences were observed between MTP and LTP in mechanical stress-related genes and activated sensory neurons based on a self-contrast model of human knee OA. Cluster analysis identified DLG4 as the hub gene. Cyclic loading stress increased PSD95 (encoded by DLG4) expression in LTP cartilage, and PSD95 inhibitors could alleviate OA progression. This study suggests that inhibiting PSD95 could be a potential therapeutic strategy for preventing articular cartilage degradation.

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Obesity, Metabolic Syndrome, and Osteoarthritis—An Updated Review

Cited by 31 publications

References 238 publications

The impact of diabetes status on pain and physical function following total joint arthroplasty for hip and knee osteoarthritis: variation by sex and body mass index

The impact of diabetes status on pain and physical function following total joint arthroplasty for hip and knee osteoarthritis: variation by sex and body mass index

Weight change patterns across adulthood are associated with the risk of osteoarthritis: a population-based study

PSD95 as a New Potential Therapeutic Target of Osteoarthritis: A Study of the Identification of Hub Genes through Self-Contrast Model

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