Obesity paradox disappears in coronary artery bypass graft patients during 20-year follow-up

Hällberg, Ville; Kataja, Matti; Lahtela, Jorma; Tarkka, Matti; Inamaa, Tapio; Palomäki, Ari

doi:10.1177/2048872616633844

Cited by 23 publications

(20 citation statements)

References 32 publications

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“…In contrast to these studies, other studies have not shown an obesity paradox, and their data are summarized in Table . Coutinho and coworkers investigated the association of central obesity expressed by waist circumference and waist to hip ratio compared with BMI on mortality in a review involving 15 923 patients with CAD.…”

Section: Studies Showing No Obesity Paradox In Obese Compared With Nomentioning

confidence: 89%

“…The in‐hospital and 1‐year incidence of MACE and all‐cause mortality was similar between the NW, overweight, and obese patients (7.1%, 5.6%, and 5.5%, respectively) for MACE, and (3.3%, 2.4%, and 2.4%, respectively) for all‐cause mortality. Hallberg and colleagues studied the effects of obesity on long‐term survival in 922 patients with CAD undergoing coronary artery bypass grafting. The 10‐year survival was better in the obese (BMI ≥ 30) than the overweight (BMI 25–29.9) and NW (BMI 18.5–24.9) patients.…”

Section: Studies Showing No Obesity Paradox In Obese Compared With Nomentioning

confidence: 99%

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Obesity is bad regardless of the obesity paradox for hypertension and heart disease

Chrysant

2018

J of Clinical Hypertension

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Obesity has risen significantly worldwide and has become a major health and societal problem. 1,2 Obesity does not imply good health since obesity is associated with several major cardiovascular risk factors, which include the metabolic syndrome, hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia, which lead to increased cardiovascular and all-cause mortality in obese people. 3,4 Despite these adverse cardiovascular effects of obesity, some studies indicate better cardiovascular outcomes in obese individuals with the so called "obesity paradox," 5-10 in contrast to other studies that show adverse cardiovascular outcomes of obesity. [11][12][13][14][15][16] The obesity paradox has been demonstrated in patients with preexisting coronary artery disease (CAD) 5-10 as well as in patients with heart failure (HF) 17,18 and hypertension [19][20][21][22][23] and is giving the wrong signal in obese people and in our efforts to stem the tide of obesity in the United States and elsewhere. 24,25 Since obesity begets CAD, hypertension, and HF, it is therefore better to prevent these complications by preventing obesity instead of inviting them and then trying to treat them. In this respect, a new large study in 3.5 million people has demonstrated that obesity even in metabolically healthy persons is associated with higher cardiovascular and all-cause mortality compared with nonobese healthy individuals. 15 This commentary is based on the findings of this study together with other recent study findings.

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Section: Studies Showing No Obesity Paradox In Obese Compared With Nomentioning

confidence: 89%

Section: Studies Showing No Obesity Paradox In Obese Compared With Nomentioning

confidence: 99%

Obesity is bad regardless of the obesity paradox for hypertension and heart disease

Chrysant

2018

J of Clinical Hypertension

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show abstract

“…Some data indicate that mortality was not increased by obesity in the short-term perspective; however, this is associated with an increase in late mortality rates. [19].…”

Section: Discussionmentioning

confidence: 99%

The influence of obesity on in-hospital clinical outcomes after recanalisation of chronic total occlusions

Aldujeli¹,

Briedis

Šimaitytė

et al. 2020

Medical Research Journal

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Objectives: Recanalisation of chronic total occlusions (CTOs) in interventional cardiology is one of the most challenging and complex procedures. Currently, no data are available about the impact of BMI on success rates among CTO patients undergoing percutaneous coronary intervention. The aim of this study was to investigate the impact that BMI has on success rates, complications, and procedure characteristics among a large group of CTO patients who underwent percutaneous coronary intervention.Methods: The present study retrospectively included 420 patients who underwent percutaneous coronary intervention for at least to one chronic total occlusion. Patients were subdivided into groups according to their BMI. BMI groups were based on the World Health Organization's definitions: From 18.5 to 24.9 kg/m 2 = Normal weight; From 25 to 29.9 kg/m 2 = Overweight; From 30 to 34.9 kg/m 2 = Obesity; Greater than or equal to 35 kg/m 2 = Very obese. In order to subdivide the patients according to the complexity of the CTO-PCI, the Japanese-CTO (J-CTO) score was used prior to the interventions. Statistical analyses were performed using the SPSS 20.0 software. The value of p < 0.05 was considered as statistically significant.Results: There was a significant difference in procedure duration, volume of used contrast medium and other procedural characteristics in higher BMI categories. There was no statistically significant difference across all body mass index categories in terms of procedure success, complication rates, and outcomes (p > 0.05). Conclusion:This retrospective study indicates that BMI has no impact on in-hospital outcomes in patients with chronic total occlusion after percutaneous coronary intervention.

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“…15,24,25 Faerri rannsóknir hafa litið á langtímaárangur og niðurstöður þeirra sem birst hafa verið misvísandi hvað árangur varðar. [26][27][28][29] Markmið þessarar rannsóknar var því að varpa ljósi á langtímaárangur sjúklinga með mismikla offitu eftir kransaeðahjáveituaðgerð og bera þá saman við sjúklinga í kjörþyngd. Sérstaklega var litið á langtíma fylgikvilla og langtímalifun auk þess sem sjálfstaeðir forspárþaettir langtímalifunar voru metnir.…”

Section: á G R I Punclassified

“…Svipuðum niðurstöðum hefur verið lýst erlendis. 24,25,27,37 Í heild var 30 daga dánartíðni 2%, og var hún svipuð í öllum LÞS-hópunum. Svipuðum niðurstöðum hefur verið lýst erlendis 28,[37][38][39] , enda þótt til séu rannsóknir sem sýna laegri dánartíðni sjúklinga með háan LÞS.…”

Section: Umraeðurunclassified

Engin marktæk tengsl offitu og lifunar eftir kransæðahjáveituaðgerð

Thorkelsdottir

Johannesdottir²,

Arnadottir³

et al. 2019

LBL

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Obesity paradox disappears in coronary artery bypass graft patients during 20-year follow-up

Abstract: During long-term follow-up the obesity paradox seems to disappear due to progression of cardiometabolic disease in patients who have undergone CABG.

Cited by 23 publications

References 32 publications

Obesity is bad regardless of the obesity paradox for hypertension and heart disease

Obesity is bad regardless of the obesity paradox for hypertension and heart disease

The influence of obesity on in-hospital clinical outcomes after recanalisation of chronic total occlusions

Engin marktæk tengsl offitu og lifunar eftir kransæðahjáveituaðgerð

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