Obesity, physically demanding work and traumatic knee injury are major risk factors for knee osteoarthritis--a population-based study with a follow-up of 22 years

Toivanen, Arto T; Heliövaara, Markku; Impivaara, Olli; Arokoski, Jari; Knekt, Paul; Laurén, Hanna; Kröger, Heikki

doi:10.1093/rheumatology/kep388

Cited by 176 publications

(131 citation statements)

References 27 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…For instance, the association between work load and increased risk of knee OA was demonstrated in Ref. [23,24] Also, a physically heavy workload was shown to be detrimental to the knee joint and to increase the risk of severe OA. [7] Finally, it was shown that prolonged or repeated knee bending is a risk factor for knee OA, and that risk may be higher in jobs involving knee bending and mechanical loading.…”

Section: Discussionmentioning

confidence: 99%

Kinematic gait analysis of workers exposed to knee straining postures by Bayes decision rule

Mezghani

Gaudreault

Mitiche

et al. 2015

AIR

View full text Add to dashboard Cite

Deep knee flexion postures such as kneeling and squatting have been demonstrated, in recent review of occupational knee disorders, as a risk factor of developing knee osteoarthritis (OA). This study investigates a probabilistic method to analyze knee gait kinematics measurements of workers exposed to knee straining postures to determine if they are in any way similar to those of knee OA patients. The measurements we use are clinically relevant kinematic signals, namely the variation during a locomotion gait cycle of the angles the knee makes with respect to the three-dimensional (3D) planes of flexion/extension, internal/external rotation, and abduction/adduction. Three groups of participants were used: a set of 24 workers exposed to knee straining postures (KS workers) acting as a test group, a control group of 25 non-KS posture workers, and a reference knee OA group of 29 subjects. We compared the kinematic data of KS workers to those of knee OA patients and non-KS subjects using the Bayes decision theory. The results shows that, using the 3D data taken together or the abduction/adduction data, the KS workers resembles often to the OA patients. The analysis on the transverse plane and on sagittal plane, i.e., the flexion/extension and the internal/external rotation, are not conclusive as the similarities are not significant. The kinematic gait analysis by Bayes decision rule shows the similarity of workers exposed to knee straining postures to OA gait pattern and justifies further prospective studies of KS workers in order to assess if gait pattern could be modified even before the onset of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Kinematic gait analysis of workers exposed to knee straining postures by Bayes decision rule

Mezghani

Gaudreault

Mitiche

et al. 2015

AIR

View full text Add to dashboard Cite

show abstract

“…According to the most recent estimates by the World Health Organization, 35% of all adults are overweight (body mass index [BMI] $25 kg/m 2 ) and more than 12% are obese (BMI $30 kg/m 2 ) (1). A high BMI is a strong risk factor for the onset of knee osteoarthritis (OA) (2)(3)(4) and has been associated with the incidence of both clinical (5-7) and structural (8)(9)(10)(11)(12)(13) features of knee OA. Given the high medical costs, productivity costs, morbidity, and disability associated with knee OA, there is an increasing need for preventive measures (14).…”

Section: Introductionmentioning

confidence: 99%

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Runhaar

Vos

Middelkoop

et al. 2016

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obese women, without clinical and radiologic knee OA at baseline. Methods. A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target. Results. The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ‡2, and joint space narrowing ‡1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure. Conclusion. A reduction of ‡5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obese women. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.

show abstract

“…The association of knee osteoarthritis with occupational kneeling and squatting has been shown to increase 7-fold between the lowest and highest categories of BMI (69,70). The impact of heavy workload, obesity, and traumatic knee injuries on the development of osteoarthritis have been reported from a prospective study of a Finnish cohort with ≥20 years of follow-up (71). The combined impact of kneeling/ squatting activities and obesity may also be important for the progression of existing knee osteoarthritis symptoms (72)(73)(74).…”

mentioning

confidence: 99%

Conceptual heuristic models of the interrelationships between obesity and the occupational environment

Pandalai¹,

Schulte²,

Miller³

2013

Scand J Work Environ Health

View full text Add to dashboard Cite

Pandalai SP, Schulte PA, Miller DB. Conceptual heuristic models of the interrelationships between obesity and the occupational environment. Scand J Work Environ Health. 2013;39(3):221-232. doi:10.5271/sjweh.3363 Objective Research and interventions targeting the relationship between work, its attendant occupational hazards, and obesity are evolving but merit further consideration in the public health arena. In this discussion paper, conceptual heuristic models are described examining the role of obesity as both a risk factor and health outcome in the occupational setting.Methods PubMed was searched using specific criteria from 2000 and onwards for evidence to support conceptual models in which obesity serves as a risk factor for occupational disease or an outcome of occupational exposures. Nine models are presented: four where obesity is a risk factor and five where it is an adverse effect.Results A broad range of work-related health effects are associated with obesity including musculoskeletal disorders, asthma, liver disease, and cardiovascular disease, among others. Obesity can be associated with occupational hazards such as shift work, sedentary work, job stress, and exposure to some chemicals. Conclusion Identification of combinations of risk factors pertinent to obesity in the occupational environmentwill provide important guidance for research and prevention.Key terms cardiovascular disease; diet; endocrine disruptor; intervention study; metabolism; musculoskeletal disease; occupational health; physical activity; risk assessment.1 National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA.Correspondence to: Sudha P Pandalai, MD, PhD, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, Obesity is increasing worldwide with the 2009-2010 prevalence among US adults surpassing one-third (1, 2). Obesity is associated with genetic, behavioral, occupational, and environmental factors (3-5) and has significant economic impact (6). It is also associated with various health problems including musculoskeletal disorders (MSD), asthma, liver disease, and cardiovascular disease (CVD) (7-10). Moreover, neurohormonal and endocrine pathway disruption has been associated with obesity (11,12). Work factors, including sedentary work and taskrelated biomechanics, have been reported as risks for obesity (13)(14)(15). Variables such as irregular work hours/ sleep schedules, job stress, workplace absenteeism, and reduced productivity also contribute (16)(17)(18)(19).Although the related literature is growing, obesity in the occupational environment requires more study, for example, regarding low-wage workers and genes or other factors (20,21). Body mass index (BMI), a measure of obesity, varies by population, race, gender, and socioeconomic class (22)(23)(24). Genetics may account for ≥40% of the variation in BMI (25), but such estimates can depend on the variability of environ...

show abstract

Obesity, physically demanding work and traumatic knee injury are major risk factors for knee osteoarthritis--a population-based study with a follow-up of 22 years

Abstract: This prospective study confirms the roles of obesity, heavy work load and knee injury in the aetiology of knee OA.

Cited by 176 publications

References 27 publications

Kinematic gait analysis of workers exposed to knee straining postures by Bayes decision rule

Kinematic gait analysis of workers exposed to knee straining postures by Bayes decision rule

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Conceptual heuristic models of the interrelationships between obesity and the occupational environment

Contact Info

Product

Resources

About