Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice

Wang, Haisong; Tang, Xue; Cheserek, Maureen Jepkorir; Shi, Yonghui; Li, Guowei

doi:10.1016/j.jff.2015.06.012

Cited by 26 publications

(15 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this investigation, the fat in the HFD offers a majority of caloric intake (47.7%) which is from lard (high proportion of saturated fatty acids and oleic acids) which shown to be a strong stimulator of triglyceride synthesis and secretion by hepatocytes [35]. Some previous reports indicated that polysaccharides can prevent obesity and liver lipid accumulation via decreasing food consumption [36,37], but our results are not the same as theirs (Table 1). It is reasonable to infer that the increasing tendency of hepatic lipid accumulation among OSM supplemented groups (Figure 1 & Figure 2 and Table 3) was resulted from consumption manner (food and energy intakes) ( Table 2) while antioxidative capacities and enzymatic activities of OSMH were also influenced ( Table 2).…”

Section: Discussioncontrasting

confidence: 60%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

View full text Add to dashboard Cite

Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.

show abstract

Section: Discussioncontrasting

confidence: 60%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

View full text Add to dashboard Cite

show abstract

“…Moreover, the abundance of the genus Akkermansia in the phylum Verrucomicrobia, which was previously reported to be linked to weight reduction or a lean phenotype in both humans and rodents, was significantly enriched by SCSP and d‐SCSP in HFD‐fed mice relative to the HFD group, particularly d‐SCSP. Nevertheless, intriguingly, the level of the probiotic Bifidobacterium that was highly negatively correlated with obesity and obesity‐related diseases was not upregulated by SCSP and d‐SCSP. These findings indicate that SCSP and d‐SCSP may produce anti‐obesity effects by modifying the abundances of some specific bacterial phylotypes.…”

Section: Discussionmentioning

confidence: 96%

“…Recently, a growing body of evidence has proven that the modulation of the gut microbiota by dietary functional food ingredients can ameliorate obesity and its complications, especially polysaccharides . For example, the intake of unabsorbed fucoidan from edible brown seaweeds reduced body weight, insulin resistance, and systematic inflammation in high‐fat diet (HFD)‐fed mice mainly by increasing the growth of specific beneficial bacteria in the gut .…”

Section: Introductionmentioning

confidence: 99%

Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High‐Fat Diet‐Fed Mice

Zhu

Sun

et al. 2018

Molecular Nutrition Food Res

142

119

View full text Add to dashboard Cite

Scope Sulfated polysaccharide from sea cucumber (SCSP), Stichopus japonicus, has been shown to prevent diverse diseases, but little is known about its effects on obesity and gut microbiota in mice fed a high‐fat diet (HFD). Methods and results Diet‐induced obese, BALB/c mice are fed an HFD with or without SCSP and depolymerized SCSP (d‐SCSP, 0.004 kcal g−1) for 8 weeks. The results show that both SCSP and d‐SCSP reduce body weight, fat and liver hypertrophy, insulin resistance, and serum lipid and inflammatory cytokine levels in HFD‐fed mice. Moreover, SCSP and d‐SCSP not only prevent HFD‐induced gut disorder, as indicated by the enriched probiotic Akkermansia and reduce endotoxin‐bearing Proteobacteria, but also improve the SCFAs and endotoxin (LPS) levels and gut tissue index. Spearman's correlation analysis reveals that several specific genera are strongly correlated with obesity‐related indexes. In addition, the inhibitory effect of d‐SCSP on fat accumulation is more effective than that of SCSP, which may be related to their different regulation of the gut microbiota. Conclusions These findings suggest that SCSP can prevent diet‐induced obesity and its associated diseases by modulating the gut microbiota and improving microbial metabolites and gut tissue, and its effects can be enhanced by free‐radical depolymerization.

show abstract

“…The gastrointestinal tract (GIT) is the first organ susceptible to diet. 9 The normal microflora within the GIT comprises diverse populations of bacteria, most of which are obligate anaerobes. These cecal bacteria primarily rely on dietary components that are undigested by enzymes in the upper GIT for energy and growth.…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of Whole Grain Qingke (Tibetan Hordeum vulgare L. Zangqing 320) on the Serum Lipid Levels and Intestinal Microbiota of Rats under High-Fat Diet

Xia

Ding

et al. 2017

J. Agric. Food Chem.

View full text Add to dashboard Cite

This study investigated the hypolipidemic effect of whole grain Qingke (WGQ) and its influence on intestinal microbiota. Changes in the serum lipid, intestinal environment, and microbiota of Sprague-Dawley rats fed high-fat diets supplemented with different doses of WGQ were determined. Results showed that high doses of WGQ significantly decreased (P < 0.05) the Lee's index, serum total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol levels whereas they increased the body weight of the rats. Cecal weight and short-chain fatty acid (SCFA) concentration increased with increasing WGQ dose. An Illumina-based sequencing approach showed that the relative abundance of putative SCFA-producing bacteria Prevotella and Anaerovibrio increased in the rats fed the WGQ diet. Principal component analysis revealed a significant difference in intestinal microbiota composition after the administration of the WGQ diet. These findings provide insights into the contribution of the intestinal microbiota to the hypolipidemic effect of WGQ.

show abstract

Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice

Cited by 26 publications

References 58 publications

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High‐Fat Diet‐Fed Mice

Effect of Whole Grain Qingke (Tibetan Hordeum vulgare L. Zangqing 320) on the Serum Lipid Levels and Intestinal Microbiota of Rats under High-Fat Diet

Contact Info

Product

Resources

About