2020
DOI: 10.21037/gs.2019.12.03
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Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery

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Cited by 157 publications
(148 citation statements)
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References 131 publications
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“…For the purpose of increasing the accuracy of the study, except for four patients (0.04%) with fasting blood glucose greater than 10 mmol/L who were given insulin to interfere with blood glucose, all patients were given oral metformin to control blood glucose due to the intervention in other links of the drug is small. 2 After comprehensive intervention, the patients lost 5% of their body weight every three months was set as a node, respectively 5%, 10%, 15%.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…For the purpose of increasing the accuracy of the study, except for four patients (0.04%) with fasting blood glucose greater than 10 mmol/L who were given insulin to interfere with blood glucose, all patients were given oral metformin to control blood glucose due to the intervention in other links of the drug is small. 2 After comprehensive intervention, the patients lost 5% of their body weight every three months was set as a node, respectively 5%, 10%, 15%.…”
Section: Methodsmentioning
confidence: 99%
“… 1 Obese patients suffer from insulin sensitivity reduction and insulin resistance formation due to the decrease of insulin receptor density in fat, thus causing hyperinsulinemia, which plays an important role in the occurrence and development of cardiovascular and cerebrovascular related diseases and neurological diseases of patients, and weight loss may constitute an important part of comprehensive treatment for patients with Type-2 diabetes. 2 - 5 It is recommended in the guidelines for obesity that appropriate 5 - 10% weight loss can achieve significant metabolic improvement. Compared with 10% weight loss, 5% weight loss seems to be easier and has better compliance.…”
Section: Introductionmentioning
confidence: 99%
“…The cytokines can work as both pro-in ammatory and anti-in ammatory factors to regulate the in ammatory response and in ammation-based immune response can be bene cial in reducing cellular and tissue damage due to oxidative stress and ischemic condition [72]. Whereas, in order to maintain 'body weight homeostasis' in high-energy demanding environments like high altitude leads to an increase in blood pressure for maintaining oxygen saturation in tissues to meet the energy demand [73]. Energy demand increases due to the initiation of a negative energy balance mechanism because of acute exposure at high-altitude, which is associated with the loss of appetite (Anorexia) and leads to weight loss [74].…”
Section: Resultsmentioning
confidence: 99%
“…Similarly, adipokines like acylationstimulating protein (ASP), adiponectin and IL-6 have been proposed as a biomarker for alterations in metabolism due to high-altitude ascent at 5300m [78]. Also, the relationship between excess adiposity and increased blood pressure is well established [73,79]. The meta-in ammation process has been widely studied in obese individuals and obesity is a well-established risk factor for high-altitude diseases like AMS), especially for the Tibetan plateau region [80,81].…”
Section: Resultsmentioning
confidence: 99%
“…Проблема розвитку артеріальної гіпертензії (АГ) у пацієнтів із надлишком маси тіла є однією з найважливіших для сучасної медицини України. Її значущість пояснюється як значною поширеністю обох цих патологій, так і значним ризиком виникнення серцево-судинних катастроф у пацієнтів із надлишком маси тіла за наявності супутньої гіпертонічної хвороби [1,2].…”
Section: вступunclassified