Obesity-Related Knee Osteoarthritis—Current Concepts

Shumnalieva, Russka; Kotov, Georgi; Monov, Simeon

doi:10.3390/life13081650

Cited by 28 publications

(10 citation statements)

References 90 publications

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“…KOA is a musculoskeletal disease characterized by progressive cartilage loss, usually presenting by chronic pain, limitation of movement, and disability (22). In the current work, the median WOMAC score was 48 with IQR: 39-63, so severe knee affection was remarkable among most of OA patients as the total WOMAC score (a disease-speci c grading scale) is 96.…”

Section: Discussionmentioning

confidence: 61%

The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis

Elshaarawy,

Salama,

Salama

et al. 2024

Preprint

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Aim To examine the connection between SNPs of ADAMTS14 gene rs4747096 and KOA and to assess risk factors associated with KOA. Methods A case control study was conducted on 158 patients with KOA and 120 controls with comparable age and sex randomly recruited from National Research Centre employees. All participants were subjected to full history taking, assessment of KOA severity using WOMAC scoring system, and thorough clinical examination. Blood sample was collected for detection of ADAMTS14/rs4747096 gene polymorphism. Results The frequency of ADAMTS14 gene rs4747096 genotypes among patients with KOA was for AA 73.5%, AG 25.7% and GG 0.7% compared to controls 963%, 31.3% and 5.6% respectively and the frequency of alleles among patients was for A 86.4% and G 78.7% compared to controls (78.7% and 21.3% respectively, P < 0.05. The study found that the median levels of total WOMAC score and its domains were significantly higher among KOA patients than controls. The logistic regression analysis revealed that older age, BMI ≥ 35, long standing at work, and severe physical exercise were predictive factors for KOA (P < 0.01). Conclusion For ADAMTS14 rs4747096 genotype, the AA and AG genotypes significantly increased the risk of KOA. Older age, females, morbid obesity, prolonged standing at work, and severe physical exercise were risk factors for KOA. Further studies are encouraged to investigate the mechanism by which this genotype can affect the development of KOA.

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Section: Discussionmentioning

confidence: 61%

The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis

Elshaarawy,

Salama,

Salama

et al. 2024

Preprint

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“…Conversely, KOA could have caused VF because of the strain on the spine. In addition, obesity has already been reported to be associated with KOA [39]. Therefore, asymptomatic VFs may not explain all causal relationships with obesity and KOA.…”

Section: Discussionmentioning

confidence: 97%

Obesity Is Associated with Asymptomatic Vertebral Fractures: A Yakumo Study

Miyairi,

Nakashima,

Ito

et al. 2024

JCM

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(1) Background: Patients with primary vertebral fracture (VF) are at high risk of re-fracture and mortality. However, approximately two-thirds of patients with VFs receive minimal clinical attention. (2) Methods: The current study aimed to investigate the factors associated with asymptomatic VFs in middle-aged and elderly individuals who underwent resident health examinations. (3) Results: The current study included 217 participants aged > 50 years. VFs were diagnosed based on lateral radiographic images using Genant’s semiquantitative (SQ) method. The participants were divided into non-VF (N; SQ grade 0) and asymptomatic VF (F; SQ grades 1–3) groups. Data on body composition, blood tests, quality of life measures, and radiographic parameters were assessed. A total of 195 participants were included in the N group (mean age, 64.8 ± 7.8 years), and 22 were in the F group (mean age, 66.1 ± 7.9 years). The F group had a significantly higher body mass index (BMI), body fat percentage (BF%), and proportion of patients with knee osteoarthritis (KOA) than the N group. The F group had a significantly higher knee joint pain visual analog scale (VAS) score and painDETECT score than the N group. Logistic regression analysis showed that BF% was associated with asymptomatic VFs. (4) Conclusions: Middle-aged and elderly individuals with asymptomatic VF presented with high BMIs, BF%, and incidence of KOA.

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“…To investigate the direct causal effect of diet on KOA, we performed Multivariate Mendelian randomization (MVMR) analyses. In previous studies, it was found that KOA may be strongly influenced by obesity [ 29 ], hypertension [ 15 ], diabetes mellitus [ 30 ], and prolonged standing [ 31 ]. Therefore, we corrected for the potential interference of obesity, BMI, hypertension, diabetes and prolonged standing in the MVMR analysis.…”

Section: Methodsmentioning

confidence: 99%

Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis

Lv,

Liang,

Liu

et al. 2024

PLoS ONE

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Background Knee osteoarthritis (KOA) is a common disabling joint disease that affects millions of people worldwide. Diet may play a role in the etiology and progression of KOA, but evidence for a causal relationship is limited. We aimed to investigate the causal impact of dietary intake on KOA risk using Mendelian randomization (MR). Methods We used summary-level data from genome-wide association studies (GWAS) including dietary intake (n = 335, 394–462, 342), and KOA (n = 403, 124). We selected 6–77 genetic variants as instrumental variables for 18 dietary factors, including processed meat, poultry, beef, oily fish, non-oily fish, pork, lamb, frequency of alcohol intake, alcoholic beverages, tea, coffee, dried fruit, cereals, cheese, bread, cooked vegetables, salad/raw vegetables, and fresh fruit. We performed univariate and multivariate MR analyses to estimate the causal effect of each dietary factor on KOA risk. We also performed some sensitivity analyses to assess the validity of the MR hypothesis. Results We found that higher coffee intake was associated with increased KOA risk, whereas higher intake of dried fruits, grains, cheese, and oily fish was associated with reduced KOA risk. After multivariate adjustment, we found that coffee and oily fish intake may affect KOA through obesity, body mass index (BMI), diabetes, hypertension, and prolonged standing. Sensitivity analyses did not reveal any evidence of pleiotropy. Conclusions Our study provides new causal evidence that dietary intake may influence KOA risk. Specifically, we suggest that increased intake of dried fruits, grains, cheese, and oily fish and decreased coffee intake may be beneficial in preventing and mitigating KOA. further studies are needed to elucidate the underlying mechanisms and to confirm our findings in different populations.

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Obesity-Related Knee Osteoarthritis—Current Concepts

Cited by 28 publications

References 90 publications

The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis

The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis

Obesity Is Associated with Asymptomatic Vertebral Fractures: A Yakumo Study

Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis

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