Obesity-related nonalcoholic fatty liver: CT features and follow-up studies after low-calorie diet.

Abstract

The features on computed tomographic (CT) scans of nonalcoholic fatty liver were investigated in 24 patients with nonalcoholic fatty liver related to overweight. CT examinations were performed before and after 3 months of a low-calorie diet. The reversibility of fatty infiltration during diet therapy could be monitored by changes in appearance on repeated CT scans. Hepatic steatosis improved, as assessed from increases in attenuation values on CT scans after 3 months of the diet, and the improvement was accompanied by a decrease in the elevated serum glutamic-pyruvic transaminase activity. Hepatic fatty infiltration in these patients was not always uniform, and attenuation values in the right lobe of the liver were significantly lower than those in the left lobe. After the 3-month diet therapy, the mean liver volume was significantly reduced, while the spleen volume was unchanged. Two sequential CT examinations, performed before and after diet therapy, may be useful for evaluating obese patients with elevated serum transaminase activity.

Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial

“…In parallel to liver fat fraction reduction, our study revealed an average concomitant liver volume decrease of 152 mL in the insulin-treated group. These observations are similar to those of earlier human studies that have shown liver volume reduction in parallel to liver fat decrease in the setting of a low-calorie diet (25) or exercise and diet (26).…”

Diagnosis of fatty infiltration of the liver on contrast enhanced CT: limitations of liver-minus-spleen attenuation difference measurements

“…In addition, only measurements from the posterior twothirds of the right liver lobe were made because this region is similar to the spleen in anatomic location, with resultant similar artifacts, and we observed that attenuation values from the left lobe were consistently higher than those from the right lobe. This observation has been confirmed by others [10]. In the two patients who had fatty infiltration confined to a lobar or segmental liver region, measurements were obtained only from the abnormal region.…”

The Expression of NAD(P)H:Quinone Oxidoreductase 1 Is High in Human Adipose Tissue, Reduced by Weight Loss, and Correlates with Adiposity, Insulin Sensitivity, and Markers of Liver Dysfunction

“…Short-term studies on intentional weight loss have shown drastic improvement in all aspects of the metabolic syndrome (24), including improved glycemic control, decreased blood pressure, and reduced cholesterol levels. Furthermore, weight loss is associated with a decrease in liver TG content (25). In the present study we demonstrate that NQO1 is expressed at high levels in human adipocytes, and that the mRNA levels in AT during diet-induced weight loss are significantly correlated with several anthropometric measurements of obesity, AT depot size, measurements of glucose tolerance, and markers known to be associated with severity of hepatic steatosis.…”