2007
DOI: 10.1515/bc.2007.046
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Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 -/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

Abstract: Targeted deletion of the stearoyl-CoA desaturase 1 gene (scd1) in mouse causes obesity resistance and a severe skin phenotype. Here, we demonstrate that SCD1 deficiency disrupts the epidermal lipid barrier and leads to uncontrolled transepidermal water loss, breakdown of adaptive thermoregulation and cold resistance, as well as a metabolic wasting syndrome. The loss of omega-hydroxylated very long-chain fatty acids (VLCFA) and ceramides substituted with omega-hydroxylated VLCFA covalently linked to corneocyte … Show more

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Cited by 86 publications
(81 citation statements)
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“…Other models with similar heat loss through the skin also may protect against diet-induced obesity (Binczek et al, 2007). Nevertheless, the postprandial clearance of plasma triglycerides was markedly increased in the Apom À/À mice, even when mice were kept at 30 C, which argues against a major effect of the reduced core body temperature on BAT activity.…”
Section: Discussionmentioning
confidence: 96%
“…Other models with similar heat loss through the skin also may protect against diet-induced obesity (Binczek et al, 2007). Nevertheless, the postprandial clearance of plasma triglycerides was markedly increased in the Apom À/À mice, even when mice were kept at 30 C, which argues against a major effect of the reduced core body temperature on BAT activity.…”
Section: Discussionmentioning
confidence: 96%
“…The lipid profile of the skin affects one of its most important functions of serving as a barrier against heat and water loss to the environment (59,60). Mice with a global SCD1 deficiency have severe impairments in the structure of the skin, characterized by sebaceous gland hypoplasia, dry skin, and alopecia (17,18,(61)(62)(63). SCD1-deficient mice also have a hypermetabolic phenotype and have been shown to be resistant to weight gain, despite persistent hyperphagia (4, 6 -8).…”
Section: Discussionmentioning
confidence: 99%
“…Hepatic steatosis can develop in a dietary mouse model despite sustained downregulation of SCD1 [43]. In addition, total SCD1 deficiency resulted in a noticeable phenotype with alopecia [44], abnormalities in the epidermal lipid barrier leading to breakdown of thermoregulation and a metabolic wasting syndrome that could in part explain the excessive energy expenditure [45]. Moreover, SCD1-deficient mice on a low-fat, high-carbohydrate diet developed severe hypercholesterolaemia and had a large decrease in HDL-cholesterol levels [27].…”
Section: Discussionmentioning
confidence: 99%