Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis

Bustamante, Fabio; Brunaldi, Vítor Ottoboni; Bernardo, Wanderley Marques; Moura, Eduardo Turiani Hourneaux de; Galvão, Manoel; Santo, Marco Aurélio

doi:10.1007/s11695-017-2857-5

Cited by 49 publications

(38 citation statements)

References 31 publications

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“…The neuromuscular blockade caused by BTX-A provokes the thesis that this agent can be applied to the gastric wall, resulting in the feeling of bloating, delayed gastric emptying, early satiety, and weight loss. The main advantage of using the intragastric injection of BTX-A would be the absence of serious adverse events related to the procedure [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Is Intragastric Botulinum Toxin A Injection Effective in Obesity Treatment?

Kaya¹,

Bulut

Fersahoğlu

2020

Surgery Research and Practice

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Aims. The objective of this prospective study was to evaluate the efficacy of intragastric botulinum toxin A (BTX-A) injection for the treatment of obesity. Materials and Methods. The study was performed between January and August 2019. This is a prospective study. After 6–12 hours of fasting, the patients were submitted to upper GI endoscopy under sedation for the injection of BTX-A. A total of 250 U of BTA-X was diluted with 10 ml of 0.9% saline. Injections were administered into the gastric antrum, each containing 1 ml of prepared solution (25 U BX-A + 1 ml saline). Continuous data were compared using a two-sample t-test. Statistical significance was determined as P≤0.05. All statistical analysis was performed using SPSS for Windows 22.1 software (SPSS, Chicago, IL, USA). Results. A total of 56 patients were studied. Mean weight before gastric Botox was 85.25 ± 14.02, and mean weight after gastric Botox was 76.98 ± 12.68. Mean weight loss was approximately 9 kg in studied patients. BMI decreased about 3 units. The mean time for maximum weight loss was 60.39 ± 37.43 days. A total of 49 patients (87.5%) had reported decrease in appetite and early satiety. About 53.6% of patients were satisfied. No complications resulting from the endoscopic procedure were observed in this series. Conclusions. Intragastric BTX-A injection can be beneficial in weight loss. It is a minimally invasive, cost-effective procedure, without serious side effects.

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, there are studies showing that intragastric Botox treatment is ineffective in weight loss. Bustamante et al designed a meta-analysis with four randomized clinical trials [ 12 ]. They concluded that homogeneous randomized controlled studies did not find superiority of BTX-A versus placebo [ 6 , 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Is Intragastric Botulinum Toxin A Injection Effective in Obesity Treatment?

Kaya¹,

Bulut

Fersahoğlu

2020

Surgery Research and Practice

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“…[93][94][95] Botulinum toxin A (BTA) (not FDA approved) injection has been used in BE because of its effect on blocking the acetylcholine release that induces a transitory delay of the gastric emptying and reduction in maximal gastric capacity. 96,97 A systematic review by Bustamante and colleagues 98 stated against the use of BTA as not effective in achieving a significant TBWL greater than placebo. These results were confirmed in a very recent randomized clinical trial.…”

Section: Gastroduodenojejunal Bypass Sleeve (Gjbs)mentioning

confidence: 99%

Procedures and devices for bariatric and metabolic endoscopy

Orlandini

Gallo

Boškoski

et al. 2020

Clin Med Insights Gastroenterol

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Obesity is a leading cause of preventable death in developed countries, with a rising incidence over time. Lifestyle modification, pharmacotherapy, and bariatric surgery are the mainstays of bariatric therapy, even though burdened by several limitations in terms of efficacy or safety. Bariatric endoscopy has been developed in the last decades as a minimally invasive alternative, aimed to bridge the gap between conservative and interventional conventional therapies. This review aims to provide an updated overview of the bariatric and metabolic available endoscopic procedures and to drive the choice of the right procedure for the right patient.

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“…[ 46 ] More recently, however, a systematic review and meta-analysis of BTA injection concluded that treatment of obesity with BTA is not effective. [ 47 ]…”

Section: E Ndoscopic M Ethodsmentioning

confidence: 99%

Development of Bariatric and Metabolic Endoscopy

Wang

Zhang

2018

Chinese Medical Journal

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Objective:With the evolution of society and changes in human lifestyle, obesity is becoming increasingly prevalent worldwide, and obesity-related comorbidities such as diabetes, hyperlipidemia, hypertension, and coronary heart disease are more common. As a result, new devices and methods for bariatric and metabolic endoscopy are being developed for clinical use, offering new options for patients. This review discussed the progress in bariatric and metabolic endoscopy.Data Sources:This review was based on data in articles published in the PubMed database up to September 2017, with the following keywords: “obesity”, “endoscopy”, “weight loss”, and “metabolism”.Study Selection:Original articles about various endoscopic methods of weight loss and other reviews of bariatric and metabolic endoscopy were included and analyzed.Results:The technology of bariatric and metabolic endoscopy has advanced rapidly in recent years. The intragastric balloon (IGB), with its comparatively long period of development, is the most mature and widely used instrument. Multiple new endoscopic devices have been created in recent years, with different targets to achieve weight loss. Despite the proliferation of new devices, the lack of clinical data results in a shortage of clinical experience and instruction in the use of this new equipment.Conclusions:Bariatric and metabolic endoscopy would help obese people lose weight or prepare for bariatric surgery and hopefully alleviate some of the complications of bariatric procedures. Adequate studies and data are still needed for the new endoscopic devices.

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Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis

Cited by 49 publications

References 31 publications

Is Intragastric Botulinum Toxin A Injection Effective in Obesity Treatment?

Is Intragastric Botulinum Toxin A Injection Effective in Obesity Treatment?

Procedures and devices for bariatric and metabolic endoscopy

Development of Bariatric and Metabolic Endoscopy

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