Obestatin is associated to muscle strength, functional capacity and cognitive status in old women

Abstract

Obestatin has been proposed to have anorexigenic and anti-ghrelin actions. The objective was to study obestatin concentrations in relation to handgrip strength, functional capacity and cognitive state in old women. The prospective study included 110 women (age, 76.93±6.32) from the Mataró Ageing Study. Individuals were characterized by anthropometric variables, grip strength, Barthel and assessment of cognitive impairment [Mini Cognoscitive Examination (MCE) Spanish version], depressive status by the Geriatric Depression Scale (GDS) and frailty by the Fried criteria. Obestatin was measured by IRMA. Obestatin showed negative correlation to handgrip at basal time point (r= −0.220, p=0.023) and at 2-year follow-up (r=−0.344, p=0.002). Obestatin, divided into quartiles, showed a negative lineal association with handgrip: 11.03 ± 4.88 kg in first, 8.75±4.08 kg in second, 8.11±3.66 kg in third and 7.61±4.08 kg in fourth quartile (p=0.018). Higher obestatin levels were associated to increased weakness (categorized by handgrip of frailty criteria): 2.24±0.42 ng/ml in weak vs. 1.87±0.57 ng/ml in nonweak (p=0.01). The decrease of either MCE or Barthel scores at 2-year follow-up was significantly higher in individuals in the fourth quartile of obestatin in comparison with individuals in the first quartile (p=0.046 and p=0.019, respectively). No association was found between obestatin and GDS score and neither with frailty as a condition. Obestatin is associated to low muscle strength, and impaired functional and cognitive capacity in old women participating in the Mataró Ageing Study.

Obestatin attenuated methamphetamine-induced PC12 cells neurotoxicity via inhibiting autophagy and apoptosis

“…In addition, it is involved in different physiological functions such as myocardial functional improvement in response to risk factors, participation in cardiovascular regulations by ghrelin, improved cardiac function, suppression of apoptosis of myocardial cell and protection of cardiac cell from cardiac damage. 25,43 According to the studies, our study confirmed the neuroprotective effects of OB, which has shown that it could reduce the neurotoxic effects of METH.…”