Obestatin is present in saliva: alterations in obestatin and ghrelin levels of saliva and serum in ischemic heart disease

Özbay, Yılmaz; Aydın, Süleyman; Dağlı, Adile Ferda; Akbulut, Mehmet; Dağlı, Necati; Kılıç, Nermin; Rahman, Ali; Şahin, İ̇brahim; Polat, Veli; Özercan, H. İbrahim; Arslan, Nadi; Sensoy, Dogan

doi:10.5483/bmbrep.2008.41.1.055

Cited by 52 publications

(34 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reducing the expression of endothelial adhesion molecules like VCAM-1 confers an anti-atherogenic role to obestatin, while an increase in Ox-LDL uptake by macrophages leads to lipid accumulation and foam cell formation and eventually into fatty streak formation in the arterial wall leading to proatherogenic properties. Ozbay et al [42] demonstrated slightly higher concentrations of saliva ghrelin and obestatin in subjects with ischemic heart disease compared with control groups, suggesting that the two peptides can participate directly in the regulation of energy metabolism in ischemic heart tissue. Obestatin may also have a potential role in the regulation of blood pressure, as demonstrated by Ren et al [43] who found that there is a positive correlation between plasma obestatin concentration and mean arterial pressure in normal pregnant women and pregnant women with pregnancy-induced hypertension.…”

Section: Pathological Involvement Of Obestatinmentioning

confidence: 99%

Obestatin: An Interesting but Controversial Gut Hormone

Lacquaniti¹,

Donato²,

Chirico

et al. 2011

Ann Nutr Metab

View full text Add to dashboard Cite

Obestatin is a 23-amino acid peptide hormone released from the stomach and is present not only in the gastrointestinal tract, but also in the spleen, mammary gland, breast milk and plasma. Obestatin appears to function as part of a complex gut-brain network whereby hormones and substances from the stomach and intestines signal the brain about satiety or hunger. In contrast to ghrelin, which causes hyperphagia and obesity, obestatin appears to act as an anorectic hormone, decreasing food intake and reducing body weight gain. Further studies have shown that obestatin is also involved in improving memory, regulating sleep, affecting cell proliferation, increasing the secretion of pancreatic juice enzymes and inhibiting glucose-induced insulin secretion. This hormone has not only been studied in the field of physiology but also in the fields of obesity and diabetes mellitus, and in patients with psychogenic eating disorders. Obestatin has a role in regulating the cell cycle by exerting proliferative effects that may be seen in cell physiology and oncology. Given the current controversy regarding the effects of obestatin and its cognate ligand, this article provides the latest review of the physiological and pathological characteristics of this hormone.

show abstract

Section: Pathological Involvement Of Obestatinmentioning

confidence: 99%

Obestatin: An Interesting but Controversial Gut Hormone

Lacquaniti¹,

Donato²,

Chirico

et al. 2011

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…On the other hand, the number of trials investigating the correlation between acute pancreatitis and obestatin, the product of the same gene with ghrelin, is limited. Yet, obestatin is synthesized in a co-localized fashion with ghrelin in all organs producing ghrelin, and studies indicate that it has the reverse activity of ghrelin, regarded as anorexigenic, although a consensus has not yet been established regarding this standpoint (10). Therefore, this trial was designed to determine the role of the orexigenic "ghrelin" and anorexigenic "obestatin" hormones, if any, on the diagnosis and assessment of the severity of AP, in addition to conventional methods.…”

Section: Introductionmentioning

confidence: 99%

Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis

Kanat¹,

Ayten²,

Aydın³

et al. 2014

Turk J Gastroenterol

Self Cite

View full text Add to dashboard Cite

Background/Aims: Due to risk of morbidity and mortality, various tests and scoring systems used in the assessment of the diagnosis and severity of acute pancreatitis disease are gaining more importance every day. Most of the current scoring systems, validated by various parameters, have a sophisticated and complex structure. Research is ongoing to establish a method to diagnose the disease and determine the severity by using different and simple parameters. In this trial, we aimed to investigate the role of the orexigenic "ghrelin" and anorexigenic "obestatin" hormones, if any, on the diagnosis and assessment of the severity of acute pancreatitis. Materials and Methods: A total of 30 patients hospitalized between September 2009 and September 2010 with a diagnosis of acute pancreatitis (AP) and 25 healthy volunteers were enrolled in the trial with a prospective and randomized design. The patients were classified in two groups, mild (Ranson ≤3 and / or Apache II ≤8) and severe (Ranson >3 and/or Apache II >8) cases, as per the Ranson and Apache-II criteria; the ghrelin and obestatin levels in blood samples obtained from the patients were measured using the ELISA method. Results: Twenty-two of the 30 patients (73%) were regarded as mild pancreatitis cases, while 8 cases (27%) were diagnosed as severe pancreatitis. Comparison of the mild and severe pancreatitis groups did not reveal a statistical difference between the two groups in terms of acylated and de-acylated ghrelin values on presentation and following the initiation of oral feeding. Similarly, no significant difference was found in the comparison of the patient and the control groups in terms of acylated and de-acylated ghrelin values on presentation (p=0.863). On the other hand, acylated and de-acylated ghrelin values after initiation of oral feeding were observed to be higher in the patient group (p=0.001, p=0.000). Comparison of these two groups revealed a significant difference in obestatin values, both on presentation and after initiation of oral feeding (p=0.002 and p=0.000). Conclusion: Consistently high serum ghrelin values during pancreatic inflammation suggest that ghrelin may be used as an adjunctive parameter in the monitoring of the course of the disease. On the other hand, high obestatin values in patients on presentation indicate that this hormone is a more significant parameter in terms of diagnosis. However, no correlation was established between these two peptide hormones and the severity of AP.

show abstract

“…Salivary diagnostics also plays an important role in cardiology, i.e. in risk assessment for cardiovascular diseases in people with insulin resistance 111,112 or for acute miocardial infarction. 113 Thus, salivary alpha-amylase was reported as an independent diagnostic factor for acute myocardial infarction in patients suffering from precordial pain less than 4 h. 114 In addition, the use of nano-biochips based on salivary proteins (including C-reactive protein, myoglobin and myeloperoxidase) in patients with acute myocardial infarction was reported to be an effective technique for screening purposes.…”

mentioning

confidence: 99%

Saliva diagnostics – Current views and directions

Kaczor‐Urbanowicz

Carreras‐Presas

Aro

et al. 2016

Exp Biol Med (Maywood)

358

271

View full text Add to dashboard Cite

The purpose of this mini-review is to make an update about the present and future applications of saliva as a diagnostic biofluid in many fields of science such as dentistry, medicine and pharmacotherapy. Using saliva as a fluid for diagnostic purposes would be a huge breakthrough for both patients and healthcare providers since saliva collection is easy, non-invasive and inexpensive. We will go through the current main diagnostic applications of saliva, and provide a highlight on the emerging, newly developing technologies and tools for cancer screening, detection and monitoring. AbstractIn this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a ''mirror of the body,'' can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term ''Salivaomics'' aimed to highlight the rapid development of knowledge about various ''omics'' constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome. In the last few years, researchers have developed new technologies and validated a wide range of salivary biomarkers that will soon make the use of saliva a clinical reality. However, a great need still exists for convenient and accurate point-of-care devices that can serve as a non-invasive diagnostic tool. In addition, there is an urgent need to decipher the scientific rationale and mechanisms that convey systemic diseases to saliva. Another promising technology called liquid biopsy enables detection of circulating tumor cells (CTCs) and fragments of tumor DNA in saliva, thus enabling non-invasive early detection of various cancers. The newly developed technology-electric field-induced release and measurement (EFIRM) provides near perfect detection of actionable mutations in lung cancer patients. These recent advances widened the salivary diagnostic approach from the oral cavity to the whole physiological system, and thus point towards a promising future of salivary diagnostics for personalized individual medicine applications including clinical decisions and post-treatment outcome predictions.

show abstract

Obestatin is present in saliva: alterations in obestatin and ghrelin levels of saliva and serum in ischemic heart disease

Cited by 52 publications

References 31 publications

Obestatin: An Interesting but Controversial Gut Hormone

Obestatin: An Interesting but Controversial Gut Hormone

Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis

Saliva diagnostics – Current views and directions

Contact Info

Product

Resources

About