Obestatin stimulates the somatotrophic axis activity in sheep

Wójcik-Gładysz, Anna; Szlis, Michał; Misztal, Anna; Przybył, Bartosz; Polkowska, Jolanta

doi:10.1016/j.brainres.2017.10.036

Cited by 6 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…75-37.70; sagittal 0.18-2.32; horizontal +3.27-+8.34) and MBH (cut coordinate: anteroposterior 30.82-33.62; sagittal 0.00-2.88; horizontal 0.54-+4.53). The depths of the cuts were 2-2.5 mm for MBH and 2.5-3 mm for AHA (Wójcik-Gładysz et al, 2018). The pituitary gland was removed from the skull, weighted and divided into anterior (glandular) and posterior (nerve) parts.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Brain-derived neurotrophic factor (BDNF) affects somatotrophic axis activity in sheep

Przybył¹,

Wójcik-Gładysz²,

Gajewska³

et al. 2021

J. Anim. Feed Sci.

Self Cite

View full text Add to dashboard Cite

Section: Animals and Experimental Designmentioning

confidence: 99%

Brain-derived neurotrophic factor (BDNF) affects somatotrophic axis activity in sheep

Przybył¹,

Wójcik-Gładysz²,

Gajewska³

et al. 2021

J. Anim. Feed Sci.

Self Cite

View full text Add to dashboard Cite

“…SS includes two types, namely, SS-14 and SS-28. In growth endocrine regulation, SS exerts a negative regulatory effect on the growth axis mainly by inhibiting the spontaneous secretion of growth hormone (GH) in vivo and the secretion induced by various stimulating factors [2]. SS operates by binding to SS receptors.…”

Section: Introductionmentioning

confidence: 99%

Immunisation of the somatostatin gene alters hypothalamic-pituitary-liver gene expressions and enhances growth in Dazu black goats

Qin,

Fang,

Song

et al. 2024

Anim Biosci

View full text Add to dashboard Cite

Objective: Somatostatin (SS) plays important regulatory roles in animal growth and reproduction by affecting the synthesis and secretion of growth hormone (GH). However, the mechanism by which SS regulates growth and development in goats is still unclear.Methods: In this study, we randomly selected eight 7-month-old Dazu black goats (DBGs) of similar body weight and equally assigned four bucks as the immunised and negative control groups. The immunised group received the Salmonella typhi attenuated vaccine X9241 (ptCS/2SS-asd) orally, whilst the negative control group received the empty vector vaccine X9241 (pVAX-asd) orally.Results: The SS concentration in the serum of goats in the immunised group was significantly lower than that in the negative control group, and the daily gain was significantly higher (p<0.05). SS-14 DNA vaccine immunisation resulted in significantly higher concentrations of growth-related hormones such as GH-releasing hormone and insulin growth factor 1 (IGF-1) in the serum of goats (p<0.05). RNA-seq analysis of hypothalamus of oral SS-14 DNA vaccine and negative control DBGs identified 31 differentially expressed genes (DEGs). Pituitary gland identified 164 DEGs. A total of 246 DEGs were detected in the liver by RNA-seq. Gene ontology of DEGs was enriched in mitochondrial envelope, extracellular region, receptor binding and cell proliferation. The biological metabolic pathways associated with DEGs were explored by Kyoto encyclopedia of genes and genomes analysis. DEGs were associated with metabolic pathways, oxidative phosphorylation, vitamin digestion and absorption and galactose metabolism. These candidate genes (e.g. DGKK, CYTB, DUSP1, and LRAT) may provide references for exploring the molecular mechanisms by which SS promotes growth and development.Conclusion: Overall, these results demonstrated that the SS DNA vaccine enhanced the growth of DBGs by altering growth-related hormone concentrations and regulating the expression of growth-related genes in the hypothalamic–pituitary–liver axis.

show abstract