Object familiarization and novel-object preference in rats

Gaskin, Stéphane; Tardif, Marilyn; Cole, Emily; Piterkin, Pavel; Kayello, Lima; Mumby, Dave G.

doi:10.1016/j.beproc.2009.10.003

Cited by 114 publications

(94 citation statements)

References 29 publications

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“…This may suggest that the amount of exploration in T1 does not reflect the quality of memory encoding. On the other hand, it is also possible that discrimination ratios are not a valid estimate of memory strength, as was argued by Gaskin et al [2]. The slightly negative correlation that was observed in our study might be explained by the assumption that rats with higher e1 values spent less time familiarizing with the environment (contextual information), which has been shown to increase novelty preference [37,38].…”

Section: Exploration and Discriminationsupporting

confidence: 42%

“…Correlation coefficients found between e1 and the d measures were slightly negative, indicating that higher exploration levels in the sample trial T1 are not associated with better discrimination performance, a phenomenon previously reported by Gaskin et al [2]. This may suggest that the amount of exploration in T1 does not reflect the quality of memory encoding.…”

Section: Exploration and Discriminationmentioning

confidence: 47%

“…Since its introduction it has been referred to as Novel Object Preference (NOP) test [2], Novel Object Recognition (NOR) task [3] and Object Recognition Task (ORT) [4]. In the present paper we use the ORT abbreviation to refer to object recognition testing.…”

Section: Introductionmentioning

confidence: 99%

“…Before testing starts, the animals are often familiarized or habituated and protocols differ greatly between laboratories. In some laboratories the animals are allowed to familiarize with only the apparatus [2,11,12,23], others also introduce objects in the pre-experimental phase [25] or even let the animals undergo the full testing procedure, including injections [34,35]. Even more fundamental, there is no consensus about the definition of object investigation.…”

Section: Introductionmentioning

confidence: 99%

“…In the original test, object investigation was defined as directing the nose towards the object at a distance of 2 cm or less [1]. However, also minimal proximities of 1 cm [11] and 4 cm [2] have also been reported. Generally, climbing and leaning on objects is not considered to be object examination [36], although some do in fact consider this to be relevant object-directed behaviour [2,37,38].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Object recognition testing: Methodological considerations on exploration and discrimination measures

Akkerman

Blokland

Reneerkens

et al. 2012

Behavioural Brain Research

178

123

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Section: Exploration and Discriminationsupporting

confidence: 42%

Section: Exploration and Discriminationmentioning

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Object recognition testing: Methodological considerations on exploration and discrimination measures

Akkerman

Blokland

Reneerkens

et al. 2012

Behavioural Brain Research

178

123

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Early lesion of the reticular thalamic nucleus disrupts the structure and function of the mediodorsal thalamus and prefrontal cortex

Boukhari

Ouhaz

Ba‐M’hamed

et al. 2019

Developmental Neurobiology

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The thalamic reticular nucleus (TRN), part of the thalamus, is a thin GABAergic cell layer adjacent to the relay nuclei of the dorsal thalamus. It receives input from the cortex and other thalamic nuclei and provides major inhibitory input to each thalamic nucleus, particularly the mediodorsal nucleus (MD). As the MD is important for supporting optimal cortico-thalamo-cortical interactions during brain maturation, we hypothesized that that early damage to the TRN will cause major disturbances to the development and the functioning of the prefrontal cortex (PFC) and the MD. Rat pups at P4 were randomized in three groups: electrolytic lesion of TRN, TRN-shamlesion group, and the classical control group. Seven weeks later, all rats were tested with several behavioral and cognitive paradigms, and then perfused for histological and immunohistochemical studies. Results showed that TRN lesion rats exhibited reduced spontaneous activity, high level of anxiety, learning and recognition memory impairments. Besides the behavioral effects observed after early TRN lesions, our study showed significant cytoarchitectural and functional changes in the cingulate cortex, the dorsolateral and prelimbic subdivisions of the PFC, as well as in the MD.The assessment of the basal levels of neuronal activity revealed a significant reduction of the basal expression of C-Fos levels in the PFC. These experiments, which are the first to highlight the effects of early TRN lesions, provided evidence that early damage of the anterior part of the TRN leads to alterations that may control the development of the thalamocortical-corticothalamic pathways. K E Y W O R D S behavior, lesion, mediodorsal thalamus, prefrontal cortex, thalamic reticular nucleus 914 | EL BOUKHARI Et AL. | 915 EL BOUKHARI Et AL. How to cite this article: El Boukhari H, Ouhaz Z, Ba-M'hamed S, Bennis M. Early lesion of the reticular thalamic nucleus disrupts the structure and function of the mediodorsal thalamus and prefrontal cortex. Develop Neurobiol. 2019;79:913-933. https ://doi.

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Recognition memory: Material, processes, and substrates

Brown¹,

Warburton²,

2010

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The proposal that a system centering on the perirhinal cortex is responsible for familiarity discrimination, particularly for single items, whereas a system centering on the hippocampus is responsible for recollective and more complex associational aspects of recognition memory is reviewed in the light of recent findings. In particular, the proposal is reviewed in relation to recent animal work with rats and results from human clinical studies. Notably, progress has been made in determining potential neural memory substrate mechanisms within the perirhinal cortex in rats. Recent findings have emphasized the importance of specifying the type of material, the type of test, and the strategy used by subjects to solve recognition memory tests if substrates are to be accurately inferred. It is to be expected that the default condition is that both the hippocampal and perirhinal systems will contribute to recognition memory performance. Indeed, rat lesion experiments provide examples of where cooperation between both systems is essential. Nevertheless, there remain examples of the independent operation of the hippocampal and perirhinal systems. Overall, it is concluded that most, though not all, of the recent findings are in support of the proposal. However, there is also evidence that the systems involved in recognition memory need to include structures outside the medial temporal lobe: there are significant but as yet only partially defined roles for the prefrontal cortex and sensory association cortices in recognition memory processes.

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Object familiarization and novel-object preference in rats

Cited by 114 publications

References 29 publications

Object recognition testing: Methodological considerations on exploration and discrimination measures

Object recognition testing: Methodological considerations on exploration and discrimination measures

Early lesion of the reticular thalamic nucleus disrupts the structure and function of the mediodorsal thalamus and prefrontal cortex

Recognition memory: Material, processes, and substrates

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