To describe gene regulatory networks, this article takes the framework of the artificial genome model and proposes impulsive neural networks algorithm based on the artificial genome model. Firstly, the gene expression and the cell division tree are applied to generate spiking neurons with specific attributes, neural network structure, connection weights and specific learning rules of each neuron. Next, the gene segment duplications and divergence model are applied to design the evolutionary algorithm of impulsive neural networks at the level of the artificial genome. The dynamic changes of developmental gene regulatory networks are controlled during the whole evolutionary process. Finally, the behavior of collecting food for autonomous intelligent agent is simulated, which is driven by nerves. Experimental results demonstrate that the algorithm in this article has the evolutionary ability on large-scale impulsive neural networks.