Objective analysis of volume restoration in atrophic acne scars and skin pores: a split study using human stem cell-conditioned media

Park, Chan Seong; Park, Ji-Hye; Kim, Cho Rok; Lee, Jong Hee

doi:10.1080/09546634.2019.1628915

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…Attempts to evaluate therapeutic outcomes of acne scar treatments based on quantitation of concavities in acne scars by replica analysis [30,31] and by three‐dimensional (3D) image analysis [11,15,32] have been previously reported. Objective analysis is essential for the assessment of acne scars in order to enable the independent evaluation of raters and to ensure the reproducibility of measurements.…”

Section: Discussionmentioning

confidence: 99%

Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

et al. 2020

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Background and Objective Fractional 1064‐nm picosecond‐domain laser has recently been utilized for the treatment of atrophic acne scars and showed promising results. However, data on the safety and efficacy of this procedure in dark‐skinned patients are limited. This prospective, self‐controlled study was conducted to objectively evaluate the safety and efficacy of a 1064‐nm picosecond laser coupled with a microlens array (MLA) for the treatment of atrophic acne scars on Asian skin. Study Design/Materials and Methods Twenty‐six subjects of Fitzpatrick skin types (FSTs) III and IV with atrophic acne scars were enrolled. All subjects were treated with a 1064‐nm picosecond laser (spot size of 8 mm, fluence of 1.0 J/cm2, a repetition rate of 10 Hz) in combination with the MLA handpiece for an average of three passes, for 6 monthly sessions. Objective (measurement of scar volume using three‐dimensional (3D) photography and skin roughness analysis using ultraviolet A‐light video camera) and subjective (clinical evaluation by two blinded dermatologists) assessments were obtained at baseline and at 1, 3, and 6 months after the final treatment. Results Statistically significant reduction of the scar volume from baseline at 1, 3, and 6 months after the final treatment were observed by 3D photography and ultraviolet A‐light video camera. At the 6‐month follow‐up, 50% (13 of 26) of the subjects were rated as having at least 50% improvement of the scars. The rate of improvement significantly increased from the 1‐month follow‐up to the 6‐month follow‐up (P = 0.013). Similarly, at the 6‐month follow‐up, the scar volume (P = 0.024) and skin roughness (P = 0.001) also significantly improved, in comparison with the baseline. Mild postinflammatory hyperpigmentation (PIH) was observed to develop in approximately 18% of all the treatment sessions. All cases of PIH were temporary and resolved within 4 weeks on average. Conclusions The 1064‐nm picosecond laser with MLA is a safe therapeutic alternative for the treatment of atrophic acne scars in dark‐skinned individuals. Lasers Surg. Med. © 2020 Wiley Periodicals LLC

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Section: Discussionmentioning

confidence: 99%

Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

et al. 2020

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“…Four studies evaluated the therapeutic potential in 71 patients with a mean follow-up of 82.5 days (range 60-90). After laser treatment, topical application of MSC-CM showed greater scar volume reduction than did with the control, by 23.5% on the MSC-CM side vs. 15.0% on the control side (Park C. S. et al, 2019). Furthermore, the MSC-CM-treated side improved subjective satisfaction and clinical assessment, showing better TEWL, SCH, elasticity, roughness, and collagen density than did the controls (laser alone or DMEM).…”

Section: Clinical Studiesmentioning

confidence: 86%

“…No clinical study specifically evaluated the effects of MSC-CM on hypertrophic scar formation. Nevertheless, the effect of MSC-CM has been tested on acne scars in combination with laser therapy, showing that combined therapy had a greater effect on reducing acne scars than laser alone (Zhou et al, 2016;Abdel-Maguid et al, 2019;El-Domyati et al, 2019;Park C. S. et al, 2019). These studies are further developed in the Skin Rejuvenation section.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Twelve studies evaluated the effect of MSC-CM on skin wrinkles (Seo et al, 2013;Zhou et al, 2013;Xu et al, 2016;Kim et al, 2018;Prakoeswa et al, 2019;El-Domyati et al, 2020; and acne scars (Zhou et al, 2016;Abdel-Maguid et al, 2019;El-Domyati et al, 2019;Park C. S. et al, 2019; Table 10). MSCs were isolated from human tissues: adipose tissue (Zhou et al, 2013(Zhou et al, , 2016Xu et al, 2016;Park C. S. et al, 2019) (30.77%, 4/13), amniotic fluid (Abdel-Maguid et al, 2019;El-Domyati et al, 2019Prakoeswa et al, 2019) (30.77%, 4/13), umbilical cord blood (Kim et al, 2018; (15.38%, 2/13), human embryos (Seo et al, 2013; (15.38%, 2/13), and the placenta (Xu et al, 2016). Two hundred six healthy volunteers were treated with MSC-CM for anti-aging therapies (Seo et al, 2013;Zhou et al, 2013;Xu et al, 2016;Kim et al, 2018;Prakoeswa et al, 2019;El-Domyati et al, 2020;.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Moreover, MSC-CM was also tested on acne scars (Zhou et al, 2016;Abdel-Maguid et al, 2019;El-Domyati et al, 2019;Park C. S. et al, 2019), suggesting that combined therapy (laser+MSC-CM) may increase the regenerative effects of fractional laser. Four studies evaluated the therapeutic potential in 71 patients with a mean follow-up of 82.5 days (range 60-90).…”

Section: Clinical Studiesmentioning

confidence: 99%

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Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

Montero‐Vílchez

Sierra-Sánchez

Sánchez‐Díaz

et al. 2021

Front. Cell Dev. Biol.

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The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.

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Quantitative assessment of the long‐term efficacy and safety of a 1064‐nm picosecond laser with fractionated microlens array in the treatment of enlarged pores in Asians: A case‐control study

et al. 2021

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Background Enlarged facial pores are one of the common skin signs of photoaging that patients seek treatment for. However, objective data and long‐term assessment on the efficacy and safety of therapeutic procedures for this condition are limited. Objective To objectively evaluate the efficacy and safety of a 1064‐nm picosecond laser with microlens array (MLA) for pore tightening. Methods Twenty‐five patients with enlarged pores received three treatments with a 1064‐nm picosecond laser coupled with MLA at 4‐week intervals. Patients were evaluated using objective (measurement of pore volume using three‐dimensional photography) and subjective (clinical evaluation by two blinded dermatologists) assessments at baseline and at the 1‐, 3‐, and 6‐month follow‐ups. Adverse effects were also recorded during each visit. Results After three treatments, there was a significant reduction of pore size from baseline (p < 0.001). The improvement in pore size appearance significantly continued from the 1‐month to the 6‐month follow‐up visits (p = 0.013). The total average pore size was 1.15652 ± 0.614322 and 0.8087 ± 0.50515 at baseline and at 6 months after the final treatment, respectively, resulting in an average of 30% reduction in pore size. No cases of dyspigmentation, textural alteration, or scarring were documented. Conclusion Fractional 1064‐nm picosecond laser appears to be effective and safe for reducing pore size in Asians with minimal transient side effects.

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Objective analysis of volume restoration in atrophic acne scars and skin pores: a split study using human stem cell-conditioned media

Cited by 12 publications

References 21 publications

Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

Objective and Long‐Term Evaluation of the Efficacy and Safety of a 1064‐nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians

Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

Quantitative assessment of the long‐term efficacy and safety of a 1064‐nm picosecond laser with fractionated microlens array in the treatment of enlarged pores in Asians: A case‐control study

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