Objective Assessment of Local Retinal Function by Focal Macular and Multifocal Electroretinograms

Shinoda, Kei; Matsumoto, Celso Soiti; Ohde, Hisao

doi:10.5772/22666

Cited by 2 publications

(3 citation statements)

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“…The recorded FMERGs consisted of a-, b-, and d-waves, the oscillatory potentials (OPs), and the photopic negative response (PhNR). Since then, FMERGs have been used to assess the physiological condition of retinal neural cells including the photoreceptors in the macular area [ 2 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are essentially three ways to deliver a stimulus to a specific area of the retina under fundus observation; through a fundus camera as is done with the Miyake system [ 2 – 7 ], through a slit-lamp microscope[ 8 , 9 ], or through a direct ophthalmoscope [ 10 ]. All of these methods are non-invasive and easily performed in the clinic, and several investigators have evaluated the macular function in different macular diseases with one of these methods.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Macular Function during Vitrectomy: New Approach Using Intraoperative Focal Macular Electroretinograms

et al. 2015

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PurposeTo describe a new technique to record focal macular electroretinograms (FMERGs) during vitrectomy to assess macular function.MethodsIntraoperative FMERGs (iFMERGs) were recorded in ten patients (10 eyes) who undergo vitrectomy. iFMERGs were elicited by focal macular stimulation. The stimulus light was directed to the macular area through a 25 gauge (25G) glass fiber optic bundle. Background light was delivered through a dual chandelier-type light fiber probe. Focal macular responses elicited with combinations of stimulus and background luminances were analyzed.ResultsA stimulus luminance that was approximately 1.75 log units brighter than the background light was able to elicit focal macular responses that were not contaminated by stray light responses. Thus, a stimulus luminance of 160 cd/m2 delivered on a background of 3 cd/m2 elicited iFMEGs from only the stimulated area. This combination of stimulus and background luminances did not elicit a response when the stimulus was projected onto the optic nerve head. The iFMERGs elicited by a 10° stimulus with a duration of 100 ms and an interstimulus interval of 150 ms consisted of an a-, b-, and d-waves, the oscillatory potentials, and the photopic negative response (PhNR).ConclusionsFocal ERGs with all components can be recorded from the macula and other retinal areas during vitreous surgery. This new technique will allow surgeons to assess the function of focal areas of the retina intraoperatively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Macular Function during Vitrectomy: New Approach Using Intraoperative Focal Macular Electroretinograms

et al. 2015

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“…The recorded FMERGs consisted of an a-, b-, and d-waves, the OPs, and the photopic negative response (PhNR). Since then, FMERGs have been used to assess the physiological condition of the different types of retinal neural cells including the photoreceptors in the macular area 25 26 27 28 29 30 .…”

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confidence: 99%

Intraoperative electrophysiological evaluations of macular function during peripheral scleral indentation

Akiyama

Matsumoto

Shinoda

et al. 2016

Sci Rep

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Scleral indentation is widely used to examine the peripheral fundus, however it can increase the intraocular pressure (IOP) to high levels which can then affect retinal function. We evaluated the effects of scleral indentation on the macular function electrophysiologically. Intraoperative focal macular electroretinograms (iFMERGs) were recorded with and without controlling the IOP in 7 eyes. Without IOP control, the IOP increased from 21.7 ± 4.9 to 92.7 ± 20.2 mmHg significantly (P = 0.020) and the amplitudes of the b-wave (from 6.29 ± 1.160 to 3.71 ± 1.98 uV, P = 0.007), on-photopic negative response (from 2.29 ± 0.99 to 0.72 ± 0.47 uV, on-PhNR, P = 0.005), and d-wave (from 2.57 ± 0.41 to 1.64 ± 0.69 uV, P = 0.007) decreased significantly soon after beginning the indentation. All values returned to the baseline levels after releasing the indentation. In the eyes with IOP controlled, the IOP and the amplitude of all components did not change significantly during and after the indentation except the on-PhNR amplitude which was significantly reduced during the indentation. The changes in the iFMERGs and macular function caused by scleral indentation were transient and reversible. The changes can be minimized by controlling the IOP.

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Objective Assessment of Local Retinal Function by Focal Macular and Multifocal Electroretinograms

Cited by 2 publications

References 61 publications

Assessment of Macular Function during Vitrectomy: New Approach Using Intraoperative Focal Macular Electroretinograms

Assessment of Macular Function during Vitrectomy: New Approach Using Intraoperative Focal Macular Electroretinograms

Intraoperative electrophysiological evaluations of macular function during peripheral scleral indentation

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