Objective assessment of psychiatric changes produced by reserpine in Egyptian schizophrenics

Soueif, M.I.; Abdelnaby, Sherouk M; Helmy, Abd-El-Kader

doi:10.1016/0001-6918(64)90008-3

Cited by 2 publications

(1 citation statement)

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“…It should also be mentioned that most of these tools were already used on various Egyptian groups (psychiatric and nonpsychiatric) and proved to be of clinical value. [13][14][15] FINDINGS Analysis of variance based on 3 X 3 x 2 factorial design was the statistical method of choice. The following comparisons and interactions were, thus, supplied for each test variable: comparisons between drug takers and controls irrespective of literacy and residence, between levels of literacy irrespective of drug consumption and residence, and between residence positions on a continuum of "urbanism-ruralism" regardless of drug behavior and literacy; interactions between drug consumption and literacy, between drug consumption and residence, between literacy and residence, and among drug consumption, literacy, and residence.…”

Section: Testsmentioning

confidence: 99%

Differential Association Between Chronic Cannabis Use and Brain Function Deficits

Soueif

1976

Annals of the New York Academy of Sciences

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To summarize, 12 objective tests that generated 16 test variables were administered to 850 male regular cannabis users and 839 nonusers. The tests were designed to assess various modalities, including speed of psychomotor performance, distance estimation, time estimation, immediate memory, and visuomotor coordination. Most of the test variables differentiated significantly between consumers and controls. At the same time, a significant second-order interaction emerged in most cases. This interaction meant that, under certain conditions that relate to the two dimensions "literacy-illiteracy" and/or "urbanism-ruralism," the superiority of controls over cannabis users became impressive, whereas under other conditions it almost disappeared. To account for this complex pattern of results, a working hypothesis was presented to the effect that "other conditions being equal, the lower the nondrug level of proficiency on tests of cognitive and psychomotor performance the smaller the size of function deficit associated with drug usage." For an empirical examination of the hypothesis, six predictions were formulated. Three predictions defined specific relationships between level of performance, on one hand, and each of three organismic variables, on the other: literacy, urbanism, and age. The remaining predictions delineated relationships to be expected between size of function deficit and the three organismic variables. All our predictions were confirmed, showing less function impairment to be contingent with cannabis usage among the illiterates, rurals, and older subjects. Level of cortical arousal was suggested as the central process associated with the three organismic variables. Because the version of our working hypothesis was formulated with reference to chronic material, the possibility of a transposition of the paradign to research on the acute effects of the drug was discussed. The suggestion was made that our working hypothesis, in either version, is capable of establishing genuine integration between reports that present conflicting results on possible function deficits contingent with cannabis consumption.

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Section: Testsmentioning

confidence: 99%