Objective evaluation of the quality of voice following radiation therapy for T1 glottic cancer

Aref, Amr; Dworkin, James Paul; Devi, Syamala; Denton, L; Fontanesi, James

doi:10.1016/s0167-8140(97)00154-0

Cited by 42 publications

(32 citation statements)

References 16 publications

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“…This superiority is generally observed by the patient heror himself, by the family, and/or by the physician. However, when assessed by acoustic analysis and speech aerodynamic studies, the quality of the voice does not return to normal following irradiation [2]. This is probably due to the tumor itself, or because RT produces a geometric asymmetry and, henceforth, a loss of elasticity of the vocal folds.…”

Section: Resultsmentioning

confidence: 99%

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

et al. 2004

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Section: Resultsmentioning

confidence: 99%

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

et al. 2004

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“…Although RT was reported superior to laser surgery in terms of voice preservation, a number of studies have reported that the voice does not return to normal after RT (20,21). Other studies comparing laser surgery and RT as treatment options reported comparable local control and voice quality outcomes from the two treatment modalities (22).…”

Section: Discussionmentioning

confidence: 99%

Imrt in Image-Guided Single Vocal Cord Irradiation

Osman¹,

Astreinidou²,

Keskin-Cambay³

et al. 2009

Radiotherapy and Oncology

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Purpose: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques. Methods and Materials: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions. Results: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose ± standard deviation to the planning target volume was 67 ± 1 Gy. The contralateral vocal cord dose was reduced from 66 ± 1 Gy in the conventional plans to 39 ± 8 Gy and 36 ± 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk. Conclusions: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.

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“…Recent studies on functional results describe a wide range of incidence of abnormal voice quality 14-92% after radiotherapy and 17-70% after laser surgery, respectively. [6][7][8][9][10][11][12] Furthermore, studies on the influence of deteriorated voice on quality of life revealed that 27-58% of patients with voice problems experienced difficulties in communication leading to a disrupted social life. 8,[13][14][15][16][17][18][19][20][21][22] Evidently, a considerable number of patients treated for early glottic cancer have to deal with voice problems in daily life.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Efficacy of Voice Therapy in Patients With Voice Problems After Treatment of Early Glottic Cancer

et al. 2012

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Objective evaluation of the quality of voice following radiation therapy for T1 glottic cancer

Cited by 42 publications

References 16 publications

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

Imrt in Image-Guided Single Vocal Cord Irradiation

Long-Term Efficacy of Voice Therapy in Patients With Voice Problems After Treatment of Early Glottic Cancer

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