Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects

Abstract

Objective measurement of local rod and cone function using gaze-controlled chromatic pupil campimetry in healthy subjects.

Chromatic Pupil Campimetry Reveals Functional Defects in Exudative Age-Related Macular Degeneration with Differences Related to Disease Activity

“…Furthermore, our stimulus characteristics were chosen to predominantly stimulate cones; the protocol has been previously established and validated in a normal cohort and example cases of patients with PDE6A-retinitis pigmentosa and CNGA3-achromatopsia, respectively, as a proof of concept. 22 A limitation of the current study is the relatively small number of subjects changing between active and inactive status in the course of the disease. Moreover, as we only have one measurement session for the control group and subgroup 2 and 3 revealed relatively big differences between two measurements for some individuals, we are limited in the interpretation of the results regarding latency in AMD patients.…”

“…Furthermore, our stimulus characteristics were chosen to predominantly stimulate cones; the protocol has been previously established and validated in a normal cohort and example cases of patients with PDE6A -retinitis pigmentosa and CNGA3 -achromatopsia, respectively, as a proof of concept. 22 …”

“…The CPC-device is depicted in a recent publication. 22 Stimuli were presented at 41 different locations at central (0°), 3°, 6°, 12°, 20°, and 30°eccentricity of the visual field, and repeated four times in the center (0°) and twice for the other locations (3°-30°). Stimuli were automatically repeated in case of strong artefacts (e.g., severe blinking during stimulus presentation) or if at least 90% of the initial baseline pupil diameter was not reached.…”

“…Stimulus characteristics were according to the recommendation of current standards in pupillography 23 and specifically validated including the test-retest reliability. 22 The whole examination lasted approximately 6 to 8 minutes for one tested eye.…”

Spatial and temporal resolution of the photoreceptors rescue dynamics after treatment with voretigene neparvovec

“…The scotopic CPC and the shortened protocol for DAC show a high reliability of both methods with a complementary ability to evaluate different aspects of the rod rescue. [18][19][20][21][22] on February 1, 2021 by guest. Protected by copyright.…”