Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis

D'Rozario, Angela L; Chapman, Jennifer; Phillips, Craig L.; Palmer, John H.; Hoyos, Camilla M.; Mowszowski, Loren; Duffy, Shantel L.; Marshall, Nathaniel S.; Benca, Ruth M.; Mander, Bryce A.; Grunstein, Ronald R.; Naismith, Sharon L.

doi:10.1016/j.smrv.2020.101308

Cited by 92 publications

(72 citation statements)

References 95 publications

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“…Sleep disturbances are very common in Alzheimer’s disease (AD) and represent a major clinical problem ( Pollak and Perlick, 1991 ; Moran et al, 2005 ). These symptoms appear early, and individuals with prodromal AD frequently have pronounced changes in sleep architecture and reduced sleep time ( D’Rozario et al, 2020 ). Moreover, increasing evidence supports that sleep changes might be present in preclinical AD ( Yaffe et al, 2014 ; Leng et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Sleep Time Estimated by an Actigraphy Watch Correlates With CSF Tau in Cognitively Unimpaired Elders: The Modulatory Role of APOE

López‐García

Lage

Pozueta

et al. 2021

Front. Aging Neurosci.

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There is increasing evidence of the relationship between sleep and neurodegeneration, but this knowledge is not incorporated into clinical practice yet. We aimed to test whether a basic sleep parameter, as total sleep estimated by actigraphy for 1 week, was a valid predictor of CSF Alzheimer’s Disease core biomarkers (amyloid-β-42 and –40, phosphorylated-tau-181, and total-tau) in elderly individuals, considering possible confounders and effect modifiers, particularly the APOE ε4 allele. One hundred and twenty-seven cognitively unimpaired volunteers enrolled in the Valdecilla Study for Memory and Brain Aging participated in this study. Seventy percent of the participants were women with a mean age of 65.5 years. After adjustment for covariates, reduced sleep time significantly predicted higher t-tau and p-tau. This association was mainly due to the APOE ε4 carriers. Our findings suggest that total sleep time, estimated by an actigraphy watch, is an early biomarker of tau pathology and that APOE modulates this relationship. The main limitation of this study is the limited validation of the actigraphy technology used. Sleep monitoring with wearables may be a useful and inexpensive screening test to detect early neurodegenerative changes.

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Section: Introductionmentioning

confidence: 99%

Sleep Time Estimated by an Actigraphy Watch Correlates With CSF Tau in Cognitively Unimpaired Elders: The Modulatory Role of APOE

López‐García

Lage

Pozueta

et al. 2021

Front. Aging Neurosci.

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“…It is our a priori hypothesis that these factors ally to potentially compromise comparison and reproducibility of work designed to facilitate detailed characterisation of sleep and also to assess the effects of interventions. A recent systematic review reporting objective sleep measurement findings in MCI was unable to render specific conclusions relating to microarchitectural sleep as no two studies were found to report the same parameters 10 . Similarly a systematic review exploring sleep interventions in MCI was confined to narrative review due to outcome measure heterogeneity 26 .…”

Section: Introductionmentioning

confidence: 99%

“…As opposed to solely representing a marker of established disease, sleep abnormalities are increasingly recognised to occur much earlier in the natural history of dementia, during and even preceding the Mild Cognitive Impairment (MCI) stage 9,10 . Furthermore, conditions with sleep abnormalities but normal cognition e.g.…”

Section: Introductionmentioning

confidence: 99%

Protocol for a scoping review of measurement of sleep in mild cognitive impairment and early dementia

et al. 2021

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Background: Sleep abnormalities are increasingly recognised to emerge early in dementia, at or before the Mild Cognitive Impairment (MCI) phase. Abnormal sleep accelerates cognitive decline and may directly contribute to pathophysiology. Its accurate measurement is therefore crucial, firstly to characterise sleep abnormalities in early disease potentially facilitating earlier identification of those at risk of dementia and secondly to test sleep intervention efficacy. However, it is our a priori hypothesis that sleep outcomes are reported heterogeneously inhibiting side-by-side comparison of study findings. As a translational step towards informing choice and decisions on optimal measures, this scoping review will describe measurement tools utilised and sleep parameters currently reported in early dementia and MCI. Methods: This scoping review follows the Joanna Briggs Institute Manual for Evidence Synthesis for Scoping Reviews. The search strategy consists of an electronic search of the CINAHL Plus, Embase, Medline, Psychinfo and British Nursing Index databases and date limited to articles published from 2000. Search results will be merged using reference management software and duplicates removed. 10% of returned titles and abstracts will be checked by each reviewing member to ensure continuity of decision making. Full-texts will be reviewed by at least two reviewers with discrepancies resolved by whole team consensus. A PRISMA flow diagram will document the selection process. Extracted data will be analysed and reported narratively. Discussion: This scoping review will identify which sleep parameters are reported and the means by which they are measured in people with MCI or early dementia. We intend to explore differences in reporting practice within group subsets, e.g. by dementia and study subtype. Ethics and dissemination: Ethical approval is not required due to absence of human participants. Results will be published in a peer-reviewed journal and presented at relevant academic conferences. The search strategy will be made available publicly for transparency.

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“…Despite its significance, only a few systematic reviews that investigate the relationship between sleep and MCI have been conducted. In addition, these reviews have been restricted to studies measuring sleep using polysomnography (PSG;D'Rozario et al, 2020), or to case-control designs (Hu et al, 2017), or have been limited in scope given the limited keywords used, the search of only one database, and the restricted publication range of the (January 2016-October 2017) of the included articles (Naismith & Mowszowski, 2018).…”

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confidence: 99%

Sleep, Mild Cognitive Impairment, and Interventions for Sleep Improvement: An Integrative Review

2021

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Sleep disturbance in mild cognitive impairment (MCI) is associated with progression to Alzheimer’s disease (AD), more severe AD symptoms, and worse health outcomes. The aim of this review was to examine the relationship between sleep and MCI, and the effectiveness of sleep improvement interventions for older adults with MCI or AD. An integrative review was conducted using four databases, and findings were analyzed using an iterative process. Findings from 24 studies showed that alterations in sleep increased the risk of MCI and that the sleep quality of individuals with MCI or AD was poorer than healthy controls. Changes in brain anatomy were also observed in healthy older adults with sleep disturbances. Examined interventions were shown to be effective in improving sleep. Screening for sleep disturbances in individuals with MCI/AD is crucial to mitigate neurodegenerative or neurobehavioral risks in this population.

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Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis

Cited by 92 publications

References 95 publications

Sleep Time Estimated by an Actigraphy Watch Correlates With CSF Tau in Cognitively Unimpaired Elders: The Modulatory Role of APOE

Sleep Time Estimated by an Actigraphy Watch Correlates With CSF Tau in Cognitively Unimpaired Elders: The Modulatory Role of APOE

Protocol for a scoping review of measurement of sleep in mild cognitive impairment and early dementia

Sleep, Mild Cognitive Impairment, and Interventions for Sleep Improvement: An Integrative Review

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