Objective sleep data as predictors of cognitive decline in dementia with Lewy Bodies and Parkinson's disease

Bugalho, Paulo; Magriço, Marta; Alves, Luísa; Borbinha, Cláudia

doi:10.1016/j.sleep.2021.01.042

Cited by 12 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, these results are consistent with previous cross-sectional findings, linking aggressive dream content in early PD to frontal dysfunction. 6 Although the majority of previous studies have found that RBD (both probable and polysomnography-confirmed) in PD predicts cognitive decline, [26][27][28] there have, however, been recent conflicting findings. 13,29,30 Nonetheless, given that it is well established that RBD is associated with worse cognition in PD cross-sectionally and that idiopathic RBD is associated with the subsequent development of dementia and parkinsonism, we would therefore expect an association between RBD and cognitive and/or motor decline in PD to be genuine.…”

Section: Discussionmentioning

confidence: 99%

Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease

Otaiku

2021

Movement Disord Clin Pract

View full text Add to dashboard Cite

Background Dream content alterations in Parkinson's disease (PD) are associated with motor and cognitive dysfunction cross‐sectionally. Although recent studies suggest abnormal dream content in PD might also predict cognitive decline, the relationship between dream content and motor decline in PD remains unknown. Objective To investigate whether abnormal dream content in PD predicts both motor and cognitive decline. Methods Data were obtained from the Parkinson's Progression Markers Initiative cohort study. Patients were evaluated at baseline and at the 60‐month follow‐up, with validated clinical scales, including the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), Montreal Cognitive Assessment (MoCA), and the Movement Disorder Society–Unified Parkinson's Disease Rating Scale Part III (MDS‐UPDRS III). Patients were dichotomized using RBDSQ item 2, which inquires whether they frequently experience aggression in their dreams. Regression analyses were used to assess whether frequent aggressive dreams at baseline predicted longitudinal changes in MDS‐UPDRS III and MoCA scores as well as progression to Hoehn and Yahr stage 3 (H&Y ≥ 3) and cognitive impairment. Results Of the patients, 58/224 (25.9%) reported frequent aggressive dreams at baseline. Aggressive dreams predicted a faster increase in MDS‐UPDRS III scores (β = 4.64; P = 0.007) and a faster decrease in MoCA scores (β = −1.49; P = 0.001). Furthermore, they conferred a 6‐fold and 2‐fold risk for progressing to H&Y ≥ 3 (odds ratio [OR] = 5.82; P = 0.005) and cognitive impairment (OR, 2.35; P = 0.023) within 60 months. These associations remained robust when adjusting for potential confounders. Conclusions This study demonstrates for the first time that frequent aggressive dreams in newly diagnosed PD may independently predict early motor and cognitive decline.

show abstract

Section: Discussionmentioning

confidence: 99%

Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease

Otaiku

2021

Movement Disord Clin Pract

View full text Add to dashboard Cite

show abstract

“…In PD patients a REM sleep behavior (RBD) diagnosis has been shown to be predictive of faster cognitive decline [55]. Notably, tonic excessive muscular activity, but not other RBD features, has shown some predictive value [78]. In recently diagnosed non-medicated PD patients, the occurrence of cognitive decline at 2-year follow-up can be predicted using a model combining information on age, non-motor assessments (University of Pennsylvania Smell Inventory Test UPSIT and RBD questionnaire), dopamine transporter SPECT imaging (caudate uptake), and CSF biomarkers (CSF A-beta 42) [55].…”

Section: Risk Factors For Dementia In Pdd and Dlbmentioning

confidence: 99%

Parkinsonism and dementia

Koros

Stefanis

Scarmeas

2022

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Twenty studies investigated subjective sleep, 12,[21][22][23][24][25][26][27][28][29][30][31][76][77][78][79][80][81][82]88 where 12 used participant, caregiver or informant questionnaires 12,[21][22][23][25][26][27][28]76,81,82,88 ; two relied upon clinical evaluations and participant or informant questionnaires, 79,80 two relied upon a clinical evaluation 24,78 and one study each used a retrospective review of clinical records, 29 patient, family or caregiver reports, 30 self-report patient sleep duration estimates 77 or subjective sleep diaries. 22 Seven studies focussed on objective sleep [32][33][34][35][36]47,75,81 , where five studies used o...…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…46 The risk of dementia development following an iRBD diagnosis may also increase with time: in one study, 19% of iRBD patients developed DLB or PDD at a mean follow-up of 5.1 years, 83 and this rose to 32% by 10.5 years. 50 Although only five studies have examined objective sleep in DLB using PSG, 32,33,35,36,47 these are suggestive of clear impairments to objective sleep. All five studies demonstrated that objective sleep efficiency (SE%), which is a marker of sleep quality, was extremely low in DLB; for example, in one study, patients had a mean SE% value of 56%, 33 which is well below the expected normative values (approx.…”

Section: Nature Of Sleep Disturbancesmentioning

confidence: 99%

“…50 Although only five studies have examined objective sleep in DLB using PSG, 32,33,35,36,47 these are suggestive of clear impairments to objective sleep. All five studies demonstrated that objective sleep efficiency (SE%), which is a marker of sleep quality, was extremely low in DLB; for example, in one study, patients had a mean SE% value of 56%, 33 which is well below the expected normative values (approx.…”

Section: Nature Of Sleep Disturbancesmentioning

confidence: 99%

See 1 more Smart Citation

Sleep disturbances in Lewy body dementia: A systematic review

Elder

Lázár

Alfonso‐Miller

et al. 2022

Int J Geriat Psychiatry

View full text Add to dashboard Cite

Background: Lewy body dementia (LBD) refers to both dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). Sleep disturbances are common in LBD, and can include poor sleep quality, excessive daytime sleepiness (EDS), and rapid eye movement behaviour disorder (RBD). Despite the high clinical prevalence of sleep disturbances in LBD, they are under-studied relative to other dementias. The aim of the present systematic review was to examine the nature of sleep disturbances in LBD, summarise the effect of treatment studies upon sleep, and highlight specific and necessary directions for future research. Methods: Published studies in English were located by searching PubMED and PSYCArticles databases (until 10 June 2022). The search protocol was preregistered in PROSPERO (CRD42021293490) and performed in accordance with PRISMA guidelines. Results: Following full-text review, a final total of 70 articles were included. These included 20 studies focussing on subjective sleep, 14 on RBD, 8 on EDS, 7 on objective sleep, and 1 on circadian rhythms. The majority of the 18 treatment studies used pharmacological interventions (n = 12), had an open-label design (n = 8), and were of low-to-moderate quality. Most studies (n = 55) included only patients with DLB. Due to the heterogeneity of the studies, we reported a narrative synthesis without meta-analysis. Conclusions: At least one form of sleep disturbance may be present in as many as 90% of people with LBD. Subjectively poor sleep quality, excessive daytime sleepiness, and RBD are more common and severe in LBD relative to other dementias.

show abstract

Objective sleep data as predictors of cognitive decline in dementia with Lewy Bodies and Parkinson's disease

Cited by 12 publications

References 29 publications

Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease

Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease

Parkinsonism and dementia

Sleep disturbances in Lewy body dementia: A systematic review

Contact Info

Product

Resources

About