Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/hippocampus and various nodes of the default mode network

Regen, Wolfram; Kyle, Simon D.; Nissen, Christoph; Feige, Bernd; Baglioni, Chiara; Hennig, Jürgen; Riemann, Dieter; Spiegelhalder, Kai

doi:10.1503/jpn.140290

Cited by 75 publications

(67 citation statements)

References 66 publications

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“…A recent study focusing on waking DMN FC in individuals with insomnia did not find any significant differences compared with healthy controls or an association with subjective measures of sleep efficiency (Regen et al, 2016). Our observations may suggest that FC differences in insomnia could be more pronounced during sleep rather than in wake.…”

Section: Subjective Measures and The Dmn Fc During Sleepcontrasting

confidence: 60%

“…The importance of prior sleep for PCC FC is supported by previous research showing reductions in PCC FC with increased sleep pressure from partial sleep deprivation (Sämann et al, 2010), as well as further reductions in DMN FC more generally with sleep deprivation during wake (Gujar et al, 2010;Yeo et al, 2015). In addition, FC changes in the DMN in people with insomnia were found to be significantly negatively correlated with sleep efficiency, that is, individuals with poor sleep efficiency were more likely to have greater FC in the DMN during wake (Regen et al, 2016). This interpretation in terms of sleep pressure relies upon the assumption that people with shorter sleep duration have a sleep debt and hence increased sleep pressure, a link which has been observed and suggested to be the result of variation in sleep duration between individuals driven by selfselected sleep restriction (Klerman & Dijk, 2005).…”

Section: Objective Sleep Measures and Dmn Fc During Sleepmentioning

confidence: 60%

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Objective and subjective measures of prior sleep–wake behavior predict functional connectivity in the default mode network during NREM sleep

et al. 2018

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IntroductionPrior sleep behavior has been shown to correlate with waking resting‐state functional connectivity (FC) in the default mode network (DMN). However, the impact of sleep history on FC during sleep has not been investigated. The aim of this study was to establish whether there is an association between intersubject variability in habitual sleep behaviors and the strength of FC within the regions of the DMN during non‐rapid eye movement (NREM) sleep.MethodsWrist actigraphy and sleep questionnaires were used as objective and subjective measures of habitual sleep behavior, and EEG‐functional MRI during NREM sleep was used to quantify sleep.ResultsThere was a significant, regionally specific association between the interindividual variability in objective (total sleep time on the night before scanning) and subjective (Insomnia Severity Index) measures of prior sleep–wake behavior and the strength of DMN FC during subsequent wakefulness and NREM sleep. In several cases, FC was related to sleep measures independently of sleep stage, suggesting that previous sleep history effects sleep FC globally across the stages.ConclusionsThis work highlights the need to consider a subject's prior sleep history in studies utilizing FC analysis during wakefulness and sleep, and indicates the complexity of the impact of sleep on the brain both in the short and long term.

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Section: Subjective Measures and The Dmn Fc During Sleepcontrasting

confidence: 60%

Section: Objective Sleep Measures and Dmn Fc During Sleepmentioning

confidence: 60%

Objective and subjective measures of prior sleep–wake behavior predict functional connectivity in the default mode network during NREM sleep

et al. 2018

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“…Previous studies of insomnia had an inconsistent conclusion on the functional connectivity within the DMN. In one study, insomniacs showed a significantly decreased functional connectivity between the medial prefrontal cortex (mPFC) and the right medial temporal lobe (rMTL), and also between the left MTL and the left inferior parietal cortices (Dai et al., ), while another study suggested stronger functional connectivity between retrosplenial cortex/hippocampus and various nodes of DMN in patients with ID (Regen et al., ). Moreover, it appeared to alter the functional connectivity between parietal and prefrontal cortices in insomniacs, inducing memory retrieval deficits (Li et al., ).…”

Section: Introductionmentioning

confidence: 99%

Rest but busy: Aberrant resting‐state functional connectivity of triple network model in insomnia

Dong

Qin

et al. 2018

Brain and Behavior

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IntroductionOne classical hypothesis among many models to explain the etiology and maintenance of insomnia disorder (ID) is hyperarousal. Aberrant functional connectivity among resting‐state large‐scale brain networks may be the underlying neurological mechanisms of this hypothesis. The aim of current study was to investigate the functional network connectivity (FNC) among large‐scale brain networks in patients with insomnia disorder (ID) during resting state.MethodsIn the present study, the resting‐state fMRI was used to evaluate whether patients with ID showed aberrant FNC among dorsal attention network (DAN), frontoparietal control network (FPC), anterior default mode network (aDMN), and posterior default mode network (pDMN) compared with healthy good sleepers (HGSs). The Pearson's correlation analysis was employed to explore whether the abnormal FNC observed in patients with ID was associated with sleep parameters, cognitive and emotional scores, and behavioral performance assessed by questionnaires and tasks.ResultsPatients with ID had worse subjective thought control ability measured by Thought Control Ability Questionnaire (TCAQ) and more negative affect than HGSs. Intriguingly, relative to HGSs, patients with ID showed a significant increase in FNC between DAN and FPC, but a significant decrease in FNC between aDMN and pDMN. Exploratory analysis in patients with ID revealed a significantly positive correlation between the DAN‐FPC FNC and reaction time (RT) of psychomotor vigilance task (PVT).ConclusionThe current study demonstrated that even during the resting state, the task‐activated and task‐deactivated large‐scale brain networks in insomniacs may still maintain a hyperarousal state, looking quite similar to the pattern in a task condition with external stimuli. Those results support the hyperarousal model of insomnia.

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“…In investigations of DMN connectivity in PI, one study reported reduced rsFC between key components of the DMN compared with controls (Nie et al, 2015). Another group found no differences in DMN rsFC between PI and good sleepers but found that greater DMN rsFC during wakefulness predicted poorer sleep quality, a finding they suggested may reflect the association of ruminative mentation with both DMN activity and with insomnia (Regen et al, 2016). An additional seed-based rsFC study reported altered functional connectivity between the superior parietal lobe and frontal areas in PI compared to controls (Li et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Resting state functional connectivity in primary insomnia, generalized anxiety disorder and controls

Pace‐Schott

Zimmerman

Bottary

et al. 2017

Psychiatry Research: Neuroimaging

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Sleep abnormalities are extremely common in anxiety disorders and may contribute to their development and persistence. Their shared pathophysiological mechanisms could thus serve as biomarkers or targets for novel therapeutics. Individuals with Primary Insomnia were age- and sex-matched to controls and to persons with Generalized Anxiety Disorder. All underwent fMRI resting-state scans at 3-T. In Primary Insomnia and controls, sleep was recorded for 2 weeks using diaries and actigraphy. All participants completed state-anxiety and neuroticism inventories. Whole-brain connectivity of 6 fear- and extinction-related seeds were compared between the 3 groups using ANOVA. The only significant between-group main effect was seen for connectivity between the left amygdala seed and a bilateral cluster in the rostral anterior cingulate cortex. The latter is believed to exert top-down control over amygdala activity and their interaction may thus constitute an emotion regulatory circuit. This connectivity was significantly greatest in controls while Primary Insomnia was intermediate between that of controls and Generalized Anxiety Disorder. Across Primary Insomnia and control subjects, mean connectivity decreased with poorer sleep. Across all 3 groups, connectivity decreased with greater neuroticism and pre-scan anxiety. Decreased top-down control of the amygdala may increase risk of developing an anxiety disorder with preexisting Primary Insomnia.

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Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/hippocampus and various nodes of the default mode network

Cited by 75 publications

References 66 publications

Objective and subjective measures of prior sleep–wake behavior predict functional connectivity in the default mode network during NREM sleep

Objective and subjective measures of prior sleep–wake behavior predict functional connectivity in the default mode network during NREM sleep

Rest but busy: Aberrant resting‐state functional connectivity of triple network model in insomnia

Resting state functional connectivity in primary insomnia, generalized anxiety disorder and controls

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